CL2017001353A1 - Ácido benzoico, derivados de ácido benzoico, y conjugados de ácido carboxílico heteroarilo de oxicodona - Google Patents

Ácido benzoico, derivados de ácido benzoico, y conjugados de ácido carboxílico heteroarilo de oxicodona

Info

Publication number
CL2017001353A1
CL2017001353A1 CL2017001353A CL2017001353A CL2017001353A1 CL 2017001353 A1 CL2017001353 A1 CL 2017001353A1 CL 2017001353 A CL2017001353 A CL 2017001353A CL 2017001353 A CL2017001353 A CL 2017001353A CL 2017001353 A1 CL2017001353 A1 CL 2017001353A1
Authority
CL
Chile
Prior art keywords
benzoic acid
conjugates
oxycodone
heteroaryl carboxylic
technology
Prior art date
Application number
CL2017001353A
Other languages
English (en)
Inventor
Travis Mickle
Sven Guenther
Sanjib Bera
Bindu Bera
Jaroslaw Kanski
Andrea K Martin
Original Assignee
Kempharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kempharm Inc filed Critical Kempharm Inc
Publication of CL2017001353A1 publication Critical patent/CL2017001353A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

<p>LA PRESENTE TECNOLOGÍA PROPORCIONA COMPOSICIONES QUE COMPRENDEN ÁCIDOS ARIL CARBOXÍLICOS Y, POR EJEMPLO AINE, CONJUGADOS QUÍMICAMENTE A OXIMORFONA (4,5-Α-EPOXI-3,14-DIHIDROXI-17-METILMORFINAN-6-ONA) PARA FORMAR NUEVOS PROFÁRMACOS/ COMPOSICIONES DE OXIMORFONA, INCLUYENDO BENZOATOS, SALICILATOS, PROPIONATOS, FENAMATOS, Y ACETATOS, QUE TIENEN UN POTENCIAL DISMINUIDO DE ABUSO DE LA OXIMORFONA. LA PRESENTE TECNOLOGÍA TAMBIÉN PROPORCIONA MÉTODOS DE TRATAMIENTO DE PACIENTES, KITS FARMACÉUTICOS Y MÉTODOS DE SÍNTESIS DE LOS CONJUGADOS DE LA PRESENTE TECNOLOGÍA.</p>
CL2017001353A 2014-11-25 2017-05-25 Ácido benzoico, derivados de ácido benzoico, y conjugados de ácido carboxílico heteroarilo de oxicodona CL2017001353A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462084216P 2014-11-25 2014-11-25
US201462084246P 2014-11-25 2014-11-25

Publications (1)

Publication Number Publication Date
CL2017001353A1 true CL2017001353A1 (es) 2018-01-05

Family

ID=56075034

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017001353A CL2017001353A1 (es) 2014-11-25 2017-05-25 Ácido benzoico, derivados de ácido benzoico, y conjugados de ácido carboxílico heteroarilo de oxicodona

Country Status (18)

Country Link
US (3) US9850252B2 (es)
EP (1) EP3223819A4 (es)
JP (2) JP6400848B2 (es)
KR (2) KR20190049944A (es)
CN (1) CN106999486A (es)
AU (1) AU2015353502B2 (es)
BR (1) BR112017011069A2 (es)
CA (1) CA2967424C (es)
CL (1) CL2017001353A1 (es)
CO (1) CO2017005201A2 (es)
IL (1) IL252470B (es)
MX (1) MX2017006520A (es)
NZ (1) NZ731591A (es)
PH (1) PH12017500963A1 (es)
RU (1) RU2683317C2 (es)
SG (1) SG11201704178UA (es)
WO (1) WO2016086113A1 (es)
ZA (1) ZA201703154B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
JP6400848B2 (ja) 2014-11-25 2018-10-03 ケムファーム・インコーポレーテッド オキシコドンの安息香酸、安息香酸誘導体及びヘテロアリールカルボン酸結合体
US20200038383A1 (en) * 2016-10-14 2020-02-06 Kempharm, Inc. Immediate-release abuse deterrent compositions or medicaments for treating pain, add, adhd and other syndromes or disorders
CN111107849B (zh) 2017-07-20 2024-03-29 苏州润鑫达泰生物医药有限公司 抗滥用长效释放阿片样前药
US11845759B2 (en) 2018-02-23 2023-12-19 Rhodes Technologies Opioid compounds and uses thereof

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GB320749A (es)
US1731152A (en) 1925-10-27 1929-10-08 Firm C H Boehringer Sohn Process for the manufacture of derivatives of dihydrocodeinone or its substitution products
AT229496B (de) 1961-03-08 1963-09-25 Lannacher Heilmittel Verfahren zur Darstellung des neuen Nicotinsäureesters des Dihydrohydroxycodeinons
US4668685A (en) 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
SE9003665D0 (sv) 1990-11-16 1990-11-16 Kabivitrum Ab Morphine prodrugs
GB9423542D0 (en) 1994-11-22 1995-01-11 Marples Brian A Pharmaceutical compounds
US5869669A (en) 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
JP2004501067A (ja) 2000-01-28 2004-01-15 ローム　アンド　ハース　カンパニー 高められた特性をもつ医薬
NZ529661A (en) 2001-06-05 2006-03-31 Control Delivery Systems Sustained-release analgesic compounds
US7375082B2 (en) 2002-02-22 2008-05-20 Shire Llc Abuse-resistant hydrocodone compounds
EP1531844B1 (en) 2002-02-22 2014-08-20 Shire LLC Novel sustained release pharmaceutical compounds to prevent abuse of controlled substances
US20040058946A1 (en) * 2002-07-05 2004-03-25 Buchwald Stephen L. Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
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KR100915284B1 (ko) 2003-09-30 2009-09-03 샤이어 엘엘씨 과용 또는 남용을 예방하기 위한 제약 조성물
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UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
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CN105749294A (zh) * 2011-10-26 2016-07-13 凯姆制药公司 氢吗啡酮的苯甲酸缀合物、苯甲酸衍生物缀合物和杂芳基羧酸缀合物、其前药、制备和使用方法
JP6400848B2 (ja) 2014-11-25 2018-10-03 ケムファーム・インコーポレーテッド オキシコドンの安息香酸、安息香酸誘導体及びヘテロアリールカルボン酸結合体

Also Published As

Publication number Publication date
CO2017005201A2 (es) 2017-08-31
CA2967424C (en) 2023-05-02
IL252470A0 (en) 2017-07-31
RU2683317C2 (ru) 2019-03-28
JP6400848B2 (ja) 2018-10-03
ZA201703154B (en) 2019-03-27
SG11201704178UA (en) 2017-06-29
RU2017122144A3 (es) 2018-12-26
JP2017535593A (ja) 2017-11-30
CN106999486A (zh) 2017-08-01
US10544153B2 (en) 2020-01-28
KR20170094249A (ko) 2017-08-17
EP3223819A1 (en) 2017-10-04
US20190048018A1 (en) 2019-02-14
EP3223819A4 (en) 2018-04-25
NZ731591A (en) 2018-06-29
PH12017500963A1 (en) 2017-10-18
IL252470B (en) 2019-08-29
AU2015353502B2 (en) 2018-09-27
KR20190049944A (ko) 2019-05-09
WO2016086113A1 (en) 2016-06-02
BR112017011069A2 (pt) 2018-07-10
US20180065975A1 (en) 2018-03-08
US9850252B2 (en) 2017-12-26
US10144740B2 (en) 2018-12-04
AU2015353502A1 (en) 2017-05-25
KR101976101B1 (ko) 2019-05-09
RU2017122144A (ru) 2018-12-26
CA2967424A1 (en) 2016-06-02
US20160168160A1 (en) 2016-06-16
JP2018199719A (ja) 2018-12-20
MX2017006520A (es) 2017-08-09

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