BR112017011069A2 - ácido benzóico, derivados e ácido benzóico e conjugados de ácido heteroaril carboxílico de oxicodona - Google Patents
ácido benzóico, derivados e ácido benzóico e conjugados de ácido heteroaril carboxílico de oxicodonaInfo
- Publication number
- BR112017011069A2 BR112017011069A2 BR112017011069A BR112017011069A BR112017011069A2 BR 112017011069 A2 BR112017011069 A2 BR 112017011069A2 BR 112017011069 A BR112017011069 A BR 112017011069A BR 112017011069 A BR112017011069 A BR 112017011069A BR 112017011069 A2 BR112017011069 A2 BR 112017011069A2
- Authority
- BR
- Brazil
- Prior art keywords
- benzoic acid
- oxycodone
- conjugates
- derivatives
- acid
- Prior art date
Links
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 title 4
- 239000005711 Benzoic acid Substances 0.000 title 2
- 235000010233 benzoic acid Nutrition 0.000 title 2
- 229960002085 oxycodone Drugs 0.000 title 1
- -1 oxycodone heteroaryl carboxylic acid Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C07D489/04—Salts; Organic complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462084246P | 2014-11-25 | 2014-11-25 | |
| US201462084216P | 2014-11-25 | 2014-11-25 | |
| PCT/US2015/062637 WO2016086113A1 (en) | 2014-11-25 | 2015-11-25 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017011069A2 true BR112017011069A2 (pt) | 2018-07-10 |
Family
ID=56075034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017011069A BR112017011069A2 (pt) | 2014-11-25 | 2015-11-25 | ácido benzóico, derivados e ácido benzóico e conjugados de ácido heteroaril carboxílico de oxicodona |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9850252B2 (enExample) |
| EP (1) | EP3223819A4 (enExample) |
| JP (2) | JP6400848B2 (enExample) |
| KR (2) | KR20190049944A (enExample) |
| CN (1) | CN106999486A (enExample) |
| AU (1) | AU2015353502B2 (enExample) |
| BR (1) | BR112017011069A2 (enExample) |
| CA (1) | CA2967424C (enExample) |
| CL (1) | CL2017001353A1 (enExample) |
| CO (1) | CO2017005201A2 (enExample) |
| IL (1) | IL252470B (enExample) |
| MX (1) | MX2017006520A (enExample) |
| NZ (1) | NZ731591A (enExample) |
| PH (1) | PH12017500963A1 (enExample) |
| RU (1) | RU2683317C2 (enExample) |
| SG (1) | SG11201704178UA (enExample) |
| WO (1) | WO2016086113A1 (enExample) |
| ZA (1) | ZA201703154B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10849981B2 (en) | 2009-07-02 | 2020-12-01 | KemPham, Inc. | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof |
| UA102916C2 (uk) | 2009-07-02 | 2013-08-27 | Кемфарм, Інк. | Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань |
| MX2017006520A (es) | 2014-11-25 | 2017-08-09 | Kempharm Inc * | Acido benzoico, derivados de acido benzoico y conjugados de oxicodona de acido heteroaril carboxilico. |
| US20200038383A1 (en) * | 2016-10-14 | 2020-02-06 | Kempharm, Inc. | Immediate-release abuse deterrent compositions or medicaments for treating pain, add, adhd and other syndromes or disorders |
| JP7369687B2 (ja) * | 2017-07-20 | 2023-10-26 | スーチョウ ランシンダタイ ファーマシューティクス エルティーディー シーオー． | 乱用防止長期作用型徐放性オピオイドプロドラッグ |
| CA3091826A1 (en) * | 2018-02-23 | 2019-08-29 | Rhodes Technologies | Novel opioid compounds and uses thereof |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB320749A (enExample) | ||||
| US1731152A (en) | 1925-10-27 | 1929-10-08 | Firm C H Boehringer Sohn | Process for the manufacture of derivatives of dihydrocodeinone or its substitution products |
| AT229496B (de) | 1961-03-08 | 1963-09-25 | Lannacher Heilmittel | Verfahren zur Darstellung des neuen Nicotinsäureesters des Dihydrohydroxycodeinons |
| US4668685A (en) | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| SE9003665D0 (sv) | 1990-11-16 | 1990-11-16 | Kabivitrum Ab | Morphine prodrugs |
| GB9423542D0 (en) | 1994-11-22 | 1995-01-11 | Marples Brian A | Pharmaceutical compounds |
| US5869669A (en) * | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
| JP2004501067A (ja) | 2000-01-28 | 2004-01-15 | ローム アンド ハース カンパニー | 高められた特性をもつ医薬 |
| NZ529661A (en) | 2001-06-05 | 2006-03-31 | Control Delivery Systems | Sustained-release analgesic compounds |
| US7375082B2 (en) | 2002-02-22 | 2008-05-20 | Shire Llc | Abuse-resistant hydrocodone compounds |
| AU2003219863C1 (en) | 2002-02-22 | 2009-03-05 | Shire Llc | Novel sustained release pharmaceutical compounds to prevent abuse of controlled substances |
| US20040058946A1 (en) * | 2002-07-05 | 2004-03-25 | Buchwald Stephen L. | Abuse-resistant prodrugs of oxycodone and other pharmaceuticals |
| TW200500067A (en) | 2003-01-21 | 2005-01-01 | Control Delivery Sys Inc | Salts of codrugs and uses related thereto |
| EP1782834A3 (en) * | 2003-03-13 | 2007-08-01 | Controlled Chemicals, Inc. | Oxycodone conjugates with lower abuse potential and extended duration of action |
| MXPA05009757A (es) * | 2003-03-13 | 2005-12-05 | Controlled Chemicals Inc | Conjugados de oxicodona con menor potencial de abuso y duracion de accion extendida. |
| EA008864B1 (ru) | 2003-09-30 | 2007-08-31 | Нью Ривер Фармасьютикалз Инк. | Фармацевтические композиции для предотвращения передозировки или неправильного употребления лекарственных средств |
| WO2005034859A2 (en) * | 2003-10-03 | 2005-04-21 | Elite Laboratories Inc. | Extended release formulations of opioids and method of use thereof |
| US20050203115A1 (en) * | 2004-03-10 | 2005-09-15 | Sancilio Frederick D. | Narcotic-NSAID ion pairs |
| AU2005252220B2 (en) | 2004-06-04 | 2011-06-02 | Xenoport, Inc. | Levodopa prodrugs, and compositions and uses thereof |
| US7348430B2 (en) | 2005-01-21 | 2008-03-25 | Acura Pharmaceuticals, Inc. | Production of opioid analgesics |
| AU2007238858A1 (en) * | 2006-04-10 | 2007-10-25 | Shire Llc | Mono and di-substituted oxycodone compounds and compositions |
| SG172633A1 (en) | 2006-05-26 | 2011-07-28 | Pharmacofore Inc | Controlled release of phenolic opioids |
| US20080090771A1 (en) | 2006-10-06 | 2008-04-17 | Shire Llc | Abuse-resistant hydrocodone compounds, compositions and methods of using the same |
| US8067596B2 (en) | 2007-12-17 | 2011-11-29 | Mallinckrodt Llc | Processes for the production of (+)- “Nal” morphinan compounds |
| CA2765836C (en) | 2009-07-02 | 2014-10-07 | Kempharm, Inc. | Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof |
| UA102916C2 (uk) | 2009-07-02 | 2013-08-27 | Кемфарм, Інк. | Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань |
| WO2011008636A1 (en) | 2009-07-15 | 2011-01-20 | Mallinckrodt Inc. | 3-oxy-hydromorphone derivatives |
| AU2012205733B2 (en) * | 2011-01-11 | 2015-10-08 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
| IN2014DN03009A (enExample) * | 2011-10-26 | 2015-05-08 | Kempharm Inc | |
| MX2017006520A (es) | 2014-11-25 | 2017-08-09 | Kempharm Inc * | Acido benzoico, derivados de acido benzoico y conjugados de oxicodona de acido heteroaril carboxilico. |
-
2015
- 2015-11-25 MX MX2017006520A patent/MX2017006520A/es unknown
- 2015-11-25 US US14/952,348 patent/US9850252B2/en active Active
- 2015-11-25 CN CN201580064309.XA patent/CN106999486A/zh active Pending
- 2015-11-25 KR KR1020197012631A patent/KR20190049944A/ko not_active Withdrawn
- 2015-11-25 WO PCT/US2015/062637 patent/WO2016086113A1/en not_active Ceased
- 2015-11-25 RU RU2017122144A patent/RU2683317C2/ru not_active IP Right Cessation
- 2015-11-25 BR BR112017011069A patent/BR112017011069A2/pt not_active Application Discontinuation
- 2015-11-25 NZ NZ731591A patent/NZ731591A/en not_active IP Right Cessation
- 2015-11-25 CA CA2967424A patent/CA2967424C/en active Active
- 2015-11-25 AU AU2015353502A patent/AU2015353502B2/en not_active Ceased
- 2015-11-25 EP EP15863639.9A patent/EP3223819A4/en not_active Withdrawn
- 2015-11-25 KR KR1020177017408A patent/KR101976101B1/ko not_active Expired - Fee Related
- 2015-11-25 JP JP2017528967A patent/JP6400848B2/ja not_active Expired - Fee Related
- 2015-11-25 SG SG11201704178UA patent/SG11201704178UA/en unknown
-
2017
- 2017-05-08 ZA ZA2017/03154A patent/ZA201703154B/en unknown
- 2017-05-23 IL IL252470A patent/IL252470B/en not_active IP Right Cessation
- 2017-05-25 CL CL2017001353A patent/CL2017001353A1/es unknown
- 2017-05-25 CO CONC2017/0005201A patent/CO2017005201A2/es unknown
- 2017-05-25 PH PH12017500963A patent/PH12017500963A1/en unknown
- 2017-11-14 US US15/812,730 patent/US10144740B2/en active Active
-
2018
- 2018-09-04 JP JP2018165325A patent/JP2018199719A/ja active Pending
- 2018-10-19 US US16/165,194 patent/US10544153B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PH12017500963A1 (en) | 2017-10-18 |
| WO2016086113A1 (en) | 2016-06-02 |
| IL252470A0 (en) | 2017-07-31 |
| RU2683317C2 (ru) | 2019-03-28 |
| AU2015353502A1 (en) | 2017-05-25 |
| IL252470B (en) | 2019-08-29 |
| CA2967424C (en) | 2023-05-02 |
| JP2017535593A (ja) | 2017-11-30 |
| AU2015353502B2 (en) | 2018-09-27 |
| CO2017005201A2 (es) | 2017-08-31 |
| JP6400848B2 (ja) | 2018-10-03 |
| EP3223819A1 (en) | 2017-10-04 |
| ZA201703154B (en) | 2019-03-27 |
| EP3223819A4 (en) | 2018-04-25 |
| CA2967424A1 (en) | 2016-06-02 |
| NZ731591A (en) | 2018-06-29 |
| SG11201704178UA (en) | 2017-06-29 |
| JP2018199719A (ja) | 2018-12-20 |
| KR101976101B1 (ko) | 2019-05-09 |
| MX2017006520A (es) | 2017-08-09 |
| RU2017122144A3 (enExample) | 2018-12-26 |
| US20180065975A1 (en) | 2018-03-08 |
| CN106999486A (zh) | 2017-08-01 |
| KR20190049944A (ko) | 2019-05-09 |
| CL2017001353A1 (es) | 2018-01-05 |
| US20160168160A1 (en) | 2016-06-16 |
| US20190048018A1 (en) | 2019-02-14 |
| US9850252B2 (en) | 2017-12-26 |
| US10144740B2 (en) | 2018-12-04 |
| US10544153B2 (en) | 2020-01-28 |
| KR20170094249A (ko) | 2017-08-17 |
| RU2017122144A (ru) | 2018-12-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |