BR112017011069A2 - ácido benzóico, derivados e ácido benzóico e conjugados de ácido heteroaril carboxílico de oxicodona - Google Patents

ácido benzóico, derivados e ácido benzóico e conjugados de ácido heteroaril carboxílico de oxicodona

Info

Publication number
BR112017011069A2
BR112017011069A2 BR112017011069A BR112017011069A BR112017011069A2 BR 112017011069 A2 BR112017011069 A2 BR 112017011069A2 BR 112017011069 A BR112017011069 A BR 112017011069A BR 112017011069 A BR112017011069 A BR 112017011069A BR 112017011069 A2 BR112017011069 A2 BR 112017011069A2
Authority
BR
Brazil
Prior art keywords
benzoic acid
oxycodone
conjugates
derivatives
acid
Prior art date
Application number
BR112017011069A
Other languages
English (en)
Portuguese (pt)
Inventor
K Martin Andrea
Bera Bindu
Kanski Jaroslaw
Bera Sanjib
Guenther Sven
Mickle Travis
Original Assignee
Kempharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kempharm Inc filed Critical Kempharm Inc
Publication of BR112017011069A2 publication Critical patent/BR112017011069A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BR112017011069A 2014-11-25 2015-11-25 ácido benzóico, derivados e ácido benzóico e conjugados de ácido heteroaril carboxílico de oxicodona BR112017011069A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462084216P 2014-11-25 2014-11-25
US201462084246P 2014-11-25 2014-11-25
PCT/US2015/062637 WO2016086113A1 (en) 2014-11-25 2015-11-25 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone

Publications (1)

Publication Number Publication Date
BR112017011069A2 true BR112017011069A2 (pt) 2018-07-10

Family

ID=56075034

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017011069A BR112017011069A2 (pt) 2014-11-25 2015-11-25 ácido benzóico, derivados e ácido benzóico e conjugados de ácido heteroaril carboxílico de oxicodona

Country Status (18)

Country Link
US (3) US9850252B2 (enExample)
EP (1) EP3223819A4 (enExample)
JP (2) JP6400848B2 (enExample)
KR (2) KR101976101B1 (enExample)
CN (1) CN106999486A (enExample)
AU (1) AU2015353502B2 (enExample)
BR (1) BR112017011069A2 (enExample)
CA (1) CA2967424C (enExample)
CL (1) CL2017001353A1 (enExample)
CO (1) CO2017005201A2 (enExample)
IL (1) IL252470B (enExample)
MX (1) MX2017006520A (enExample)
NZ (1) NZ731591A (enExample)
PH (1) PH12017500963A1 (enExample)
RU (1) RU2683317C2 (enExample)
SG (1) SG11201704178UA (enExample)
WO (1) WO2016086113A1 (enExample)
ZA (1) ZA201703154B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
SG11201704178UA (en) 2014-11-25 2017-06-29 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone
US20200038383A1 (en) * 2016-10-14 2020-02-06 Kempharm, Inc. Immediate-release abuse deterrent compositions or medicaments for treating pain, add, adhd and other syndromes or disorders
WO2019018638A1 (en) 2017-07-20 2019-01-24 Suzhou Runxindatai Pharmaceutics Ltd Co. PRODRUGS OF EXTENDED RELEASE OPIOID OPIOIDS RESISTANT TO ABUSE
AU2019224127B2 (en) * 2018-02-23 2021-12-09 Rhodes Technologies Novel opioid compounds and uses thereof

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB320749A (enExample)
US1731152A (en) 1925-10-27 1929-10-08 Firm C H Boehringer Sohn Process for the manufacture of derivatives of dihydrocodeinone or its substitution products
AT229496B (de) 1961-03-08 1963-09-25 Lannacher Heilmittel Verfahren zur Darstellung des neuen Nicotinsäureesters des Dihydrohydroxycodeinons
US4668685A (en) 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
SE9003665D0 (sv) 1990-11-16 1990-11-16 Kabivitrum Ab Morphine prodrugs
GB9423542D0 (en) 1994-11-22 1995-01-11 Marples Brian A Pharmaceutical compounds
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
JP2004501067A (ja) 2000-01-28 2004-01-15 ローム　アンド　ハース　カンパニー 高められた特性をもつ医薬
WO2005032474A2 (en) 2003-09-30 2005-04-14 New River Pharmaceuticals Inc. Pharmaceutical compositions for prevention of overdose or abuse
IL158882A0 (en) 2001-06-05 2004-05-12 Control Delivery Sys Inc Sustained-release analgesic compounds
US7375082B2 (en) 2002-02-22 2008-05-20 Shire Llc Abuse-resistant hydrocodone compounds
AU2003219863C1 (en) 2002-02-22 2009-03-05 Shire Llc Novel sustained release pharmaceutical compounds to prevent abuse of controlled substances
US20040058946A1 (en) 2002-07-05 2004-03-25 Buchwald Stephen L. Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
TW200500067A (en) 2003-01-21 2005-01-01 Control Delivery Sys Inc Salts of codrugs and uses related thereto
MXPA05009757A (es) * 2003-03-13 2005-12-05 Controlled Chemicals Inc Conjugados de oxicodona con menor potencial de abuso y duracion de accion extendida.
EP1782834A3 (en) * 2003-03-13 2007-08-01 Controlled Chemicals, Inc. Oxycodone conjugates with lower abuse potential and extended duration of action
CA2541371C (en) 2003-10-03 2014-12-16 Atul M. Mehta Extended release formulations of opioids and method of use thereof
US20050203115A1 (en) * 2004-03-10 2005-09-15 Sancilio Frederick D. Narcotic-NSAID ion pairs
US7342131B2 (en) 2004-06-04 2008-03-11 Xenoport, Inc. Levodopa prodrugs, and compositions and uses thereof
US7348430B2 (en) 2005-01-21 2008-03-25 Acura Pharmaceuticals, Inc. Production of opioid analgesics
EP2007762A2 (en) * 2006-04-10 2008-12-31 Shire LLC Mono and di-substituted oxycodone compounds and compositions
JP5371746B2 (ja) 2006-05-26 2013-12-18 ファーマコフォア， インコーポレイテッド フェノール性オピオイドの制御放出
US20080090771A1 (en) 2006-10-06 2008-04-17 Shire Llc Abuse-resistant hydrocodone compounds, compositions and methods of using the same
NZ586194A (en) 2007-12-17 2012-07-27 Mallinckrodt Llc Processes for the production of (+)-'nal' morphinan compounds
UA102916C2 (uk) * 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
CA2765836C (en) 2009-07-02 2014-10-07 Kempharm, Inc. Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof
WO2011008636A1 (en) 2009-07-15 2011-01-20 Mallinckrodt Inc. 3-oxy-hydromorphone derivatives
WO2012096887A2 (en) * 2011-01-11 2012-07-19 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable oxycodone prodrug
HK1197191A1 (en) * 2011-10-26 2015-01-09 Kempharm, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof
SG11201704178UA (en) 2014-11-25 2017-06-29 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone

Also Published As

Publication number Publication date
KR20190049944A (ko) 2019-05-09
AU2015353502A1 (en) 2017-05-25
KR20170094249A (ko) 2017-08-17
RU2017122144A3 (enExample) 2018-12-26
US10544153B2 (en) 2020-01-28
US9850252B2 (en) 2017-12-26
US10144740B2 (en) 2018-12-04
CO2017005201A2 (es) 2017-08-31
RU2683317C2 (ru) 2019-03-28
CL2017001353A1 (es) 2018-01-05
PH12017500963A1 (en) 2017-10-18
JP2018199719A (ja) 2018-12-20
JP2017535593A (ja) 2017-11-30
US20160168160A1 (en) 2016-06-16
CA2967424A1 (en) 2016-06-02
ZA201703154B (en) 2019-03-27
US20180065975A1 (en) 2018-03-08
KR101976101B1 (ko) 2019-05-09
CN106999486A (zh) 2017-08-01
RU2017122144A (ru) 2018-12-26
WO2016086113A1 (en) 2016-06-02
JP6400848B2 (ja) 2018-10-03
EP3223819A1 (en) 2017-10-04
US20190048018A1 (en) 2019-02-14
IL252470A0 (en) 2017-07-31
CA2967424C (en) 2023-05-02
IL252470B (en) 2019-08-29
AU2015353502B2 (en) 2018-09-27
EP3223819A4 (en) 2018-04-25
SG11201704178UA (en) 2017-06-29
MX2017006520A (es) 2017-08-09
NZ731591A (en) 2018-06-29

Similar Documents

Publication Publication Date Title
EP3691705A4 (en) URINARY CATHETER
DK3119772T3 (da) Heteroaryl syk-hæmmere
HUE058200T2 (hu) Végtag-érszorító
EP3164406C0 (en) BORONIC ACID DERIVATIVES AND THEIR THERAPEUTIC USES
HUE053552T2 (hu) Szubsztituált oxopiridin származékok
BR112017006622A2 (pt) derivados de ácido borônico
LT3204359T (lt) Tetrahidroizochinolino dariniai
DK3019099T3 (da) Elektrokirurgisk slynge
DK3288988T3 (da) Vandige dispersioner
HUE048321T2 (hu) Karabazol származékok
DK3231803T3 (da) Dihydroindolizinonderivat
IL252470A0 (en) Conjugates of oxycodone with benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid
DK3143018T3 (da) Carboxamidderivater
ZA201708157B (en) Cyclopropane carboxylic acid derivatives and pharmaceutical uses thereof
DK3131898T3 (da) Fluoroalkylfluorenderivativer
LT3445743T (lt) Aminorūgšties darinio provaistas
HRP20181280T1 (hr) Postupak za otkrivanje h.pylori infekcije
DK3200779T3 (en) Novel anthranilic acid derivatives
EP3305294A4 (en) AQUEOUS MEDICINE
DK3672977T3 (da) Boronsyrederivater
IL252472A0 (en) Conjugates of oxymorphone with benzoic acid, derivatives of benzoic acid and heteroaryl carboxylic acid, prodrugs, methods and production and use thereof
PL3137460T3 (pl) Pochodne diheterocyklu połączonego cykloalkilem
HUE048790T2 (hu) Vizes készítmény
DK3380465T3 (da) Diaminopyridinderivativer
DK3283066T3 (da) 4-Phenylsmørsyrederivater

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements