RU2683317C2 - Конъюгаты оксикодона с бензойной кислотой, производными бензойной кислоты и гетероарилкарбоновой кислотой - Google Patents

Конъюгаты оксикодона с бензойной кислотой, производными бензойной кислоты и гетероарилкарбоновой кислотой Download PDF

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Publication number
RU2683317C2
RU2683317C2 RU2017122144A RU2017122144A RU2683317C2 RU 2683317 C2 RU2683317 C2 RU 2683317C2 RU 2017122144 A RU2017122144 A RU 2017122144A RU 2017122144 A RU2017122144 A RU 2017122144A RU 2683317 C2 RU2683317 C2 RU 2683317C2
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Russia
Prior art keywords
acid
oxycodone
approximately
present technology
composition according
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RU2017122144A
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English (en)
Russian (ru)
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RU2017122144A3 (enExample
RU2017122144A (ru
Inventor
Андреа К. МАРТИН
Ярослав КАНЬСКИ
Бинду БЕРА
Санджиб БЕРА
Свен ГЮНТЕР
Тревис Микл
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Кемфарм, Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2017122144A 2014-11-25 2015-11-25 Конъюгаты оксикодона с бензойной кислотой, производными бензойной кислоты и гетероарилкарбоновой кислотой RU2683317C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462084216P 2014-11-25 2014-11-25
US201462084246P 2014-11-25 2014-11-25
US62/084,216 2014-11-25
US62/084,246 2014-11-25
PCT/US2015/062637 WO2016086113A1 (en) 2014-11-25 2015-11-25 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone

Publications (3)

Publication Number Publication Date
RU2017122144A3 RU2017122144A3 (enExample) 2018-12-26
RU2017122144A RU2017122144A (ru) 2018-12-26
RU2683317C2 true RU2683317C2 (ru) 2019-03-28

Family

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RU2017122144A RU2683317C2 (ru) 2014-11-25 2015-11-25 Конъюгаты оксикодона с бензойной кислотой, производными бензойной кислоты и гетероарилкарбоновой кислотой

Country Status (18)

Country Link
US (3) US9850252B2 (enExample)
EP (1) EP3223819A4 (enExample)
JP (2) JP6400848B2 (enExample)
KR (2) KR101976101B1 (enExample)
CN (1) CN106999486A (enExample)
AU (1) AU2015353502B2 (enExample)
BR (1) BR112017011069A2 (enExample)
CA (1) CA2967424C (enExample)
CL (1) CL2017001353A1 (enExample)
CO (1) CO2017005201A2 (enExample)
IL (1) IL252470B (enExample)
MX (1) MX2017006520A (enExample)
NZ (1) NZ731591A (enExample)
PH (1) PH12017500963A1 (enExample)
RU (1) RU2683317C2 (enExample)
SG (1) SG11201704178UA (enExample)
WO (1) WO2016086113A1 (enExample)
ZA (1) ZA201703154B (enExample)

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US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
SG11201704178UA (en) 2014-11-25 2017-06-29 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone
US20200038383A1 (en) * 2016-10-14 2020-02-06 Kempharm, Inc. Immediate-release abuse deterrent compositions or medicaments for treating pain, add, adhd and other syndromes or disorders
WO2019018638A1 (en) 2017-07-20 2019-01-24 Suzhou Runxindatai Pharmaceutics Ltd Co. PRODRUGS OF EXTENDED RELEASE OPIOID OPIOIDS RESISTANT TO ABUSE
AU2019224127B2 (en) * 2018-02-23 2021-12-09 Rhodes Technologies Novel opioid compounds and uses thereof

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US20130259909A1 (en) * 2009-07-02 2013-10-03 Kempharm, Inc. Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof

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Also Published As

Publication number Publication date
KR20190049944A (ko) 2019-05-09
AU2015353502A1 (en) 2017-05-25
KR20170094249A (ko) 2017-08-17
RU2017122144A3 (enExample) 2018-12-26
US10544153B2 (en) 2020-01-28
US9850252B2 (en) 2017-12-26
US10144740B2 (en) 2018-12-04
CO2017005201A2 (es) 2017-08-31
CL2017001353A1 (es) 2018-01-05
PH12017500963A1 (en) 2017-10-18
JP2018199719A (ja) 2018-12-20
JP2017535593A (ja) 2017-11-30
US20160168160A1 (en) 2016-06-16
CA2967424A1 (en) 2016-06-02
ZA201703154B (en) 2019-03-27
US20180065975A1 (en) 2018-03-08
KR101976101B1 (ko) 2019-05-09
CN106999486A (zh) 2017-08-01
RU2017122144A (ru) 2018-12-26
WO2016086113A1 (en) 2016-06-02
JP6400848B2 (ja) 2018-10-03
EP3223819A1 (en) 2017-10-04
US20190048018A1 (en) 2019-02-14
IL252470A0 (en) 2017-07-31
CA2967424C (en) 2023-05-02
IL252470B (en) 2019-08-29
BR112017011069A2 (pt) 2018-07-10
AU2015353502B2 (en) 2018-09-27
EP3223819A4 (en) 2018-04-25
SG11201704178UA (en) 2017-06-29
MX2017006520A (es) 2017-08-09
NZ731591A (en) 2018-06-29

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Effective date: 20201126