CL2015003615A1 - Nucleósidos sustituidos, nucleótidos y análogos de los mismos. - Google Patents
Nucleósidos sustituidos, nucleótidos y análogos de los mismos.Info
- Publication number
- CL2015003615A1 CL2015003615A1 CL2015003615A CL2015003615A CL2015003615A1 CL 2015003615 A1 CL2015003615 A1 CL 2015003615A1 CL 2015003615 A CL2015003615 A CL 2015003615A CL 2015003615 A CL2015003615 A CL 2015003615A CL 2015003615 A1 CL2015003615 A1 CL 2015003615A1
- Authority
- CL
- Chile
- Prior art keywords
- nucleotides
- analogs
- substituted nucleosides
- nucleosides
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361839756P | 2013-06-26 | 2013-06-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2015003615A1 true CL2015003615A1 (es) | 2016-09-09 |
Family
ID=52116188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2015003615A CL2015003615A1 (es) | 2013-06-26 | 2015-12-14 | Nucleósidos sustituidos, nucleótidos y análogos de los mismos. |
Country Status (23)
Country | Link |
---|---|
US (3) | US9422322B2 (fr) |
EP (2) | EP3424938B1 (fr) |
JP (2) | JP6453322B2 (fr) |
KR (1) | KR20160023711A (fr) |
CN (1) | CN105408341B (fr) |
AP (1) | AP2015008954A0 (fr) |
AU (2) | AU2014302715B2 (fr) |
BR (1) | BR112015031763A2 (fr) |
CA (1) | CA2913210C (fr) |
CL (1) | CL2015003615A1 (fr) |
DK (2) | DK3424938T3 (fr) |
EA (1) | EA201592075A1 (fr) |
ES (2) | ES2825035T3 (fr) |
GE (1) | GEP201706793B (fr) |
HK (1) | HK1222178A1 (fr) |
MX (1) | MX2015017556A (fr) |
NZ (1) | NZ714415A (fr) |
PE (1) | PE20160205A1 (fr) |
PH (1) | PH12015502799A1 (fr) |
SG (1) | SG11201509585YA (fr) |
TW (1) | TWI655199B (fr) |
UA (1) | UA118760C2 (fr) |
WO (1) | WO2014209983A1 (fr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2619215B1 (fr) | 2010-09-22 | 2018-09-05 | Alios Biopharma, Inc. | Azido nucléosides et analogues nucléotidiques |
WO2012088155A1 (fr) | 2010-12-22 | 2012-06-28 | Alios Biopharma, Inc. | Analogues de nucléotides cycliques |
EP2794630A4 (fr) | 2011-12-22 | 2015-04-01 | Alios Biopharma Inc | Analogues de nucléotide phosphorothioate substitués |
HUE041509T2 (hu) | 2011-12-22 | 2019-05-28 | Janssen Biopharma Inc | Szubsztituált nukleozidok, nukleotidok és ezek analógjai |
CN104321333A (zh) | 2012-03-21 | 2015-01-28 | 沃泰克斯药物股份有限公司 | 硫代氨基磷酸酯核苷酸前药的固体形式 |
USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
SG11201407336PA (en) | 2012-05-25 | 2015-03-30 | Janssen Sciences Ireland Uc | Uracyl spirooxetane nucleosides |
CA2894542C (fr) | 2012-12-21 | 2023-10-31 | Alios Biopharma, Inc. | Nucleosides, nucleotides substitues et leurs analogues |
CA2894541A1 (fr) | 2012-12-21 | 2014-06-26 | Alios Biopharma, Inc. | Nucleosides, nucleotides substitues et leurs analogues |
AR099632A1 (es) | 2013-04-05 | 2016-08-10 | Alios Biopharma Inc | Tratamiento de una infección viral de hepatitis c, que usa una combinación de compuestos |
NZ714415A (en) | 2013-06-26 | 2017-09-29 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
EP3013340B9 (fr) * | 2013-06-26 | 2023-10-04 | Janssen Pharmaceuticals, Inc. | Nucléosides, nucléotides substitués et leurs analogues |
US9862743B2 (en) | 2013-10-11 | 2018-01-09 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
AP2016009653A0 (en) | 2014-06-24 | 2016-12-31 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
EP3797782A1 (fr) | 2014-06-24 | 2021-03-31 | Janssen BioPharma, Inc. | Nucléosides substitués, nucléotides et leurs analogues pour traiter les infections virales |
WO2016022464A1 (fr) * | 2014-08-05 | 2016-02-11 | Alios Biopharma, Inc. | Polythérapie pour traiter un paramyxovirus |
EP3212657A4 (fr) | 2014-10-28 | 2018-04-11 | Alios Biopharma, Inc. | Procédés de préparation d'analogues de nucléosides substitués |
WO2016074596A1 (fr) * | 2014-11-10 | 2016-05-19 | 南京曼杰生物科技有限公司 | Dérivé de phosphoramidate de nucléoside et son application |
MA41213A (fr) | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
CA2979216A1 (fr) | 2015-03-11 | 2016-09-15 | Alios Biopharma, Inc. | Composes d'aza-pyridone et leurs utilisations |
CA2984421C (fr) * | 2015-05-01 | 2024-04-09 | Cocrystal Pharma, Inc. | Analogues de nucleosides a utiliser pour le traitement d'infections par des virus de la famille des flaviviridae et du cancer |
LT3324977T (lt) | 2015-07-22 | 2022-10-25 | Enanta Pharmaceuticals, Inc. | Benzodiazepino dariniai kaip rsv inhibitoriai |
US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
BR112020006334A2 (pt) * | 2017-09-29 | 2020-09-24 | Enanta Pharmaceuticals, Inc. | combinação de agentes farmacêuticos como inibidores de rsv |
CA3113425A1 (fr) * | 2018-09-21 | 2020-03-26 | Shanghai De Novo Pharmatech Co., Ltd. | Analogue dinucleotidique cyclique, composition pharmaceutique associee et utilisation |
UY38614A (es) | 2019-03-18 | 2020-10-30 | Enanta Pharm Inc | Derivados de benzodiazepinas como inhibidores del rsv |
WO2021216722A1 (fr) * | 2020-04-23 | 2021-10-28 | Atea Pharmaceuticals, Inc. | Procédé stéréosélectif de fabrication de phosphoramidates de purine |
US11945824B2 (en) | 2020-10-19 | 2024-04-02 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
CN114773417B (zh) * | 2022-04-06 | 2023-08-22 | 郑州大学 | 一种虫草素磷酸酯及其制备方法与应用 |
Family Cites Families (40)
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US5674998A (en) | 1989-09-15 | 1997-10-07 | Gensia Inc. | C-4' modified adenosine kinase inhibitors |
US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
MY134070A (en) | 2001-01-22 | 2007-11-30 | Isis Pharmaceuticals Inc | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
GB0114286D0 (en) | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
US7951789B2 (en) | 2006-12-28 | 2011-05-31 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
AU2008334948B2 (en) | 2007-12-13 | 2014-11-20 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for prevention or treatment of RSV infection |
NZ593647A (en) | 2008-12-23 | 2013-08-30 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
JP2012521359A (ja) | 2009-03-20 | 2012-09-13 | アリオス バイオファーマ インク. | 置換されたヌクレオシドアナログおよびヌクレオチドアナログ |
EP2619215B1 (fr) | 2010-09-22 | 2018-09-05 | Alios Biopharma, Inc. | Azido nucléosides et analogues nucléotidiques |
GEP20156313B (en) | 2010-09-22 | 2015-07-10 | Alios Biopharma Inc | Substituted nucleotide analogs |
US20120070411A1 (en) | 2010-09-22 | 2012-03-22 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
WO2012088155A1 (fr) | 2010-12-22 | 2012-06-28 | Alios Biopharma, Inc. | Analogues de nucléotides cycliques |
HUE041509T2 (hu) | 2011-12-22 | 2019-05-28 | Janssen Biopharma Inc | Szubsztituált nukleozidok, nukleotidok és ezek analógjai |
EP2794630A4 (fr) | 2011-12-22 | 2015-04-01 | Alios Biopharma Inc | Analogues de nucléotide phosphorothioate substitués |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
CN104321333A (zh) | 2012-03-21 | 2015-01-28 | 沃泰克斯药物股份有限公司 | 硫代氨基磷酸酯核苷酸前药的固体形式 |
SG10201804571TA (en) | 2012-03-21 | 2018-07-30 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
WO2013142159A1 (fr) | 2012-03-21 | 2013-09-26 | Alios Biopharma, Inc. | Combinaisons pharmaceutiques comprenant un analogue thionucléotidique |
EP2828278A4 (fr) | 2012-03-21 | 2015-12-09 | Alios Biopharma Inc | Procédés de préparation d'analogues de nucléotide substitués |
WO2013142157A1 (fr) | 2012-03-22 | 2013-09-26 | Alios Biopharma, Inc. | Combinaisons pharmaceutiques comprenant un analogue thionucléotidique |
CA2894541A1 (fr) | 2012-12-21 | 2014-06-26 | Alios Biopharma, Inc. | Nucleosides, nucleotides substitues et leurs analogues |
CA2894542C (fr) | 2012-12-21 | 2023-10-31 | Alios Biopharma, Inc. | Nucleosides, nucleotides substitues et leurs analogues |
US20150065439A1 (en) | 2013-02-28 | 2015-03-05 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions |
WO2014164533A1 (fr) | 2013-03-11 | 2014-10-09 | Vertex Pharmaceuticals Incorporated | Méthodes de synthèse stéréosélective d'analogues nucléosidiques substitués |
AR099632A1 (es) | 2013-04-05 | 2016-08-10 | Alios Biopharma Inc | Tratamiento de una infección viral de hepatitis c, que usa una combinación de compuestos |
EP3013340B9 (fr) | 2013-06-26 | 2023-10-04 | Janssen Pharmaceuticals, Inc. | Nucléosides, nucléotides substitués et leurs analogues |
NZ714415A (en) * | 2013-06-26 | 2017-09-29 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
US9862743B2 (en) | 2013-10-11 | 2018-01-09 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
EA201692473A1 (ru) | 2014-06-24 | 2017-03-31 | Элиос Биофарма, Инк. | Способы получения замещенных нуклеотидных аналогов |
EP3797782A1 (fr) | 2014-06-24 | 2021-03-31 | Janssen BioPharma, Inc. | Nucléosides substitués, nucléotides et leurs analogues pour traiter les infections virales |
AP2016009653A0 (en) | 2014-06-24 | 2016-12-31 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
US20160022724A1 (en) | 2014-07-22 | 2016-01-28 | Alios Biopharma, Inc. | Methods for treating paramyxoviruses |
WO2016022464A1 (fr) | 2014-08-05 | 2016-02-11 | Alios Biopharma, Inc. | Polythérapie pour traiter un paramyxovirus |
EP3212657A4 (fr) | 2014-10-28 | 2018-04-11 | Alios Biopharma, Inc. | Procédés de préparation d'analogues de nucléosides substitués |
MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
MA41213A (fr) | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
MA45925A (fr) | 2016-08-12 | 2019-06-19 | Janssen Biopharma Inc | Nucléosides et nucléotides substitués et leurs analogues |
WO2018081449A1 (fr) | 2016-10-27 | 2018-05-03 | Alios Biopharma, Inc. | Méthode pour le traitement d'une infection par le virus respiratoire syncytial |
EP3684782A1 (fr) | 2017-09-18 | 2020-07-29 | Janssen BioPharma, Inc. | Nucléosides substitués, nucléotides et analogues de ceux-ci |
-
2014
- 2014-06-24 NZ NZ714415A patent/NZ714415A/en not_active IP Right Cessation
- 2014-06-24 ES ES18174398T patent/ES2825035T3/es active Active
- 2014-06-24 GE GEAP201414043A patent/GEP201706793B/en unknown
- 2014-06-24 TW TW103121826A patent/TWI655199B/zh not_active IP Right Cessation
- 2014-06-24 SG SG11201509585YA patent/SG11201509585YA/en unknown
- 2014-06-24 MX MX2015017556A patent/MX2015017556A/es unknown
- 2014-06-24 EP EP18174398.0A patent/EP3424938B1/fr active Active
- 2014-06-24 EP EP14817999.7A patent/EP3013843B1/fr active Active
- 2014-06-24 JP JP2016523850A patent/JP6453322B2/ja not_active Expired - Fee Related
- 2014-06-24 DK DK18174398.0T patent/DK3424938T3/da active
- 2014-06-24 CA CA2913210A patent/CA2913210C/fr active Active
- 2014-06-24 UA UAA201511862A patent/UA118760C2/uk unknown
- 2014-06-24 US US14/312,990 patent/US9422322B2/en active Active
- 2014-06-24 PE PE2015002648A patent/PE20160205A1/es not_active Application Discontinuation
- 2014-06-24 AU AU2014302715A patent/AU2014302715B2/en not_active Ceased
- 2014-06-24 CN CN201480038065.3A patent/CN105408341B/zh active Active
- 2014-06-24 WO PCT/US2014/043841 patent/WO2014209983A1/fr active Application Filing
- 2014-06-24 KR KR1020157036462A patent/KR20160023711A/ko not_active Application Discontinuation
- 2014-06-24 EA EA201592075A patent/EA201592075A1/ru unknown
- 2014-06-24 BR BR112015031763A patent/BR112015031763A2/pt not_active Application Discontinuation
- 2014-06-24 ES ES14817999.7T patent/ES2685591T3/es active Active
- 2014-06-24 DK DK14817999.7T patent/DK3013843T3/en active
- 2014-06-24 AP AP2015008954A patent/AP2015008954A0/xx unknown
-
2015
- 2015-12-14 CL CL2015003615A patent/CL2015003615A1/es unknown
- 2015-12-16 PH PH12015502799A patent/PH12015502799A1/en unknown
-
2016
- 2016-07-20 US US15/215,434 patent/US9932363B2/en active Active
- 2016-09-02 HK HK16110449.8A patent/HK1222178A1/zh not_active IP Right Cessation
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2018
- 2018-02-13 US US15/895,872 patent/US10696708B2/en active Active
- 2018-12-12 JP JP2018232331A patent/JP2019059766A/ja not_active Withdrawn
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2019
- 2019-03-06 AU AU2019201536A patent/AU2019201536A1/en not_active Abandoned
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