CL2015000362A1 - Compuestos derivados de tris-(hetero)aril-pirazoles; procedimiento de preparacion; medicamento; y su uso para el tratamiento y/o profilaxis de infecciones con retrovirus, en especial vih - Google Patents

Compuestos derivados de tris-(hetero)aril-pirazoles; procedimiento de preparacion; medicamento; y su uso para el tratamiento y/o profilaxis de infecciones con retrovirus, en especial vih

Info

Publication number
CL2015000362A1
CL2015000362A1 CL2015000362A CL2015000362A CL2015000362A1 CL 2015000362 A1 CL2015000362 A1 CL 2015000362A1 CL 2015000362 A CL2015000362 A CL 2015000362A CL 2015000362 A CL2015000362 A CL 2015000362A CL 2015000362 A1 CL2015000362 A1 CL 2015000362A1
Authority
CL
Chile
Prior art keywords
pyrazoles
prophylaxis
hetero
tris
aryl
Prior art date
Application number
CL2015000362A
Other languages
English (en)
Spanish (es)
Inventor
Burkhard Klenke
Steffen Wildum
Astrid Wendt
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48986151&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015000362(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of CL2015000362A1 publication Critical patent/CL2015000362A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CL2015000362A 2012-08-17 2015-02-16 Compuestos derivados de tris-(hetero)aril-pirazoles; procedimiento de preparacion; medicamento; y su uso para el tratamiento y/o profilaxis de infecciones con retrovirus, en especial vih CL2015000362A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102012016908.6A DE102012016908A1 (de) 2012-08-17 2012-08-17 Tris-(Hetero)Aryl-Pyrazole und ihre Verwendung

Publications (1)

Publication Number Publication Date
CL2015000362A1 true CL2015000362A1 (es) 2015-07-10

Family

ID=48986151

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015000362A CL2015000362A1 (es) 2012-08-17 2015-02-16 Compuestos derivados de tris-(hetero)aril-pirazoles; procedimiento de preparacion; medicamento; y su uso para el tratamiento y/o profilaxis de infecciones con retrovirus, en especial vih

Country Status (27)

Country Link
US (1) US9249148B2 (enExample)
EP (1) EP2885300A1 (enExample)
JP (1) JP2015524835A (enExample)
KR (1) KR20150042841A (enExample)
CN (1) CN104684913B (enExample)
AP (1) AP2015008325A0 (enExample)
AR (1) AR092145A1 (enExample)
AU (1) AU2013303993A1 (enExample)
BR (1) BR112015003115A2 (enExample)
CA (1) CA2881997A1 (enExample)
CL (1) CL2015000362A1 (enExample)
CU (1) CU20150015A7 (enExample)
DE (1) DE102012016908A1 (enExample)
EA (1) EA201500232A1 (enExample)
HK (1) HK1212327A1 (enExample)
IL (1) IL237298A0 (enExample)
MA (1) MA37928A1 (enExample)
MX (1) MX2015002046A (enExample)
NZ (1) NZ704727A (enExample)
PE (1) PE20150869A1 (enExample)
PH (1) PH12015500322B1 (enExample)
SG (1) SG11201501183VA (enExample)
TN (1) TN2015000045A1 (enExample)
TW (1) TW201412720A (enExample)
UA (1) UA112488C2 (enExample)
WO (1) WO2014027112A1 (enExample)
ZA (1) ZA201501078B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102012016908A1 (de) 2012-08-17 2014-02-20 Aicuris Gmbh & Co. Kg Tris-(Hetero)Aryl-Pyrazole und ihre Verwendung
AR099428A1 (es) * 2014-02-14 2016-07-20 Aicuris Gmbh & Co Kg Combinaciones de principios activos farmacéuticos con compuestos basados en tri(hetero)aril pirazoles
EP3263567A1 (en) * 2016-07-01 2018-01-03 AiCuris Anti-infective Cures GmbH Carboxamide-substituted pyrazoles and tri(hetero)aryl-pyrazoles for use in methods of treating and / or preventing cardiovascular diseases and / or comorbidities thereof
CN111902408B (zh) * 2018-04-04 2023-11-14 日本烟草产业株式会社 杂芳基取代的吡唑化合物及其药物用途

Family Cites Families (38)

* Cited by examiner, † Cited by third party
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PH27357A (en) 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
IL104311A (en) 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US6277847B1 (en) 1999-04-02 2001-08-21 Fmc Corporation Herbicidal isoindolinonyl-and 3,4-dihydroisoquinolonyl-substituted heterocycles
DE60235114D1 (de) 2001-11-01 2010-03-04 Icagen Inc Pyrazolamide zur anwendung in der behandlung von schmerz
US6649638B1 (en) * 2002-08-14 2003-11-18 Ppd Discovery, Inc. Prenylation inhibitors and methods of their synthesis and use
WO2004050632A1 (en) 2002-12-02 2004-06-17 Fujisawa Pharmaceutical Co., Ltd. Pyrazole derivatives useful as cox-i inhibitors
CA2515119A1 (en) 2003-02-07 2004-08-19 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivative
WO2005080343A2 (en) 2004-02-20 2005-09-01 Astrazeneca Ab 3-substituted 1,5-diphenylpyrazole derivatives useful as cb1 modulators
AU2005225524B2 (en) 2004-03-26 2007-11-22 F. Hoffmann-La Roche Ag Tetrahydrocarbazoles and derivatives
JPWO2006004027A1 (ja) 2004-07-01 2008-04-24 第一製薬株式会社 ピラゾール誘導体
GB0417910D0 (en) 2004-08-11 2004-09-15 Novartis Ag Organic compounds
DE102004054666A1 (de) 2004-11-12 2006-05-18 Bayer Cropscience Gmbh Substituierte Pyrazol-3-carboxamide, Verfahren zur Herstellung und Verwendung als Herbizide und Pflanzenwachstumsregulatoren
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WO2007009701A2 (en) 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazole compounds and combinations thereof for the treatment of the metabolic syndrome
EP1743637A1 (en) 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazole compounds and combinations thereof for the treatment of the metabolic syndrome
GB0516661D0 (en) 2005-08-13 2005-09-21 Astrazeneca Ab Therapeutic agents
ES2632940T3 (es) 2005-09-13 2017-09-18 Janssen Pharmaceutica Nv Derivados de tiazol sustituidos con 2-anilin-4-arilo
EP1957076A2 (en) 2005-11-29 2008-08-20 Merck & Co., Inc. Thiazole derivatives as cxcr3 receptor modulators
JP2009518298A (ja) 2005-12-01 2009-05-07 バイエル ヘルスケア リミティド ライアビリティ カンパニー 癌治療に有用な尿素化合物
CA2660261A1 (en) 2006-08-09 2008-02-14 Pfizer Products Inc. Heterocycles useful as inhibitors of carbonic anhydrase
US8188113B2 (en) 2006-09-14 2012-05-29 Deciphera Pharmaceuticals, Inc. Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
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JP4994295B2 (ja) * 2007-04-20 2012-08-08 田辺三菱製薬株式会社 医薬組成物
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AR099428A1 (es) 2014-02-14 2016-07-20 Aicuris Gmbh & Co Kg Combinaciones de principios activos farmacéuticos con compuestos basados en tri(hetero)aril pirazoles

Also Published As

Publication number Publication date
EP2885300A1 (de) 2015-06-24
DE102012016908A1 (de) 2014-02-20
AU2013303993A1 (en) 2015-03-12
NZ704727A (en) 2016-07-29
AR092145A1 (es) 2015-03-25
UA112488C2 (uk) 2016-09-12
PH12015500322B1 (en) 2019-03-25
CN104684913B (zh) 2016-11-23
MX2015002046A (es) 2015-06-05
EA201500232A1 (ru) 2015-07-30
MA37928A1 (fr) 2017-11-30
SG11201501183VA (en) 2015-05-28
HK1212327A1 (en) 2016-06-10
TN2015000045A1 (en) 2016-06-29
CA2881997A1 (en) 2014-02-20
KR20150042841A (ko) 2015-04-21
JP2015524835A (ja) 2015-08-27
BR112015003115A2 (pt) 2017-07-04
WO2014027112A1 (de) 2014-02-20
TW201412720A (zh) 2014-04-01
CN104684913A (zh) 2015-06-03
IL237298A0 (en) 2015-04-30
PE20150869A1 (es) 2015-05-27
PH12015500322A1 (en) 2015-03-30
US9249148B2 (en) 2016-02-02
ZA201501078B (en) 2017-11-29
CU20150015A7 (es) 2015-11-27
US20150203500A1 (en) 2015-07-23
AP2015008325A0 (en) 2015-03-31

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