CL2014002831A1 - Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos para tratar infestacion por helmintos. - Google Patents

Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos para tratar infestacion por helmintos.

Info

Publication number
CL2014002831A1
CL2014002831A1 CL2014002831A CL2014002831A CL2014002831A1 CL 2014002831 A1 CL2014002831 A1 CL 2014002831A1 CL 2014002831 A CL2014002831 A CL 2014002831A CL 2014002831 A CL2014002831 A CL 2014002831A CL 2014002831 A1 CL2014002831 A1 CL 2014002831A1
Authority
CL
Chile
Prior art keywords
methods
benzimidazole derivatives
parasiticidal compositions
helminth infestation
treat
Prior art date
Application number
CL2014002831A
Other languages
English (en)
Inventor
Charles Q Meng
Original Assignee
Merial Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Ltd filed Critical Merial Ltd
Publication of CL2014002831A1 publication Critical patent/CL2014002831A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CL2014002831A 2012-04-20 2014-10-20 Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos para tratar infestacion por helmintos. CL2014002831A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261635961P 2012-04-20 2012-04-20

Publications (1)

Publication Number Publication Date
CL2014002831A1 true CL2014002831A1 (es) 2014-12-12

Family

ID=48225136

Family Applications (3)

Application Number Title Priority Date Filing Date
CL2014002831A CL2014002831A1 (es) 2012-04-20 2014-10-20 Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos para tratar infestacion por helmintos.
CL2017001239A CL2017001239A1 (es) 2012-04-20 2017-05-15 Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos. (divisional solicitud 2831-2014)
CL2018003596A CL2018003596A1 (es) 2012-04-20 2018-12-14 Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos. (divisional solicitud 201402831)

Family Applications After (2)

Application Number Title Priority Date Filing Date
CL2017001239A CL2017001239A1 (es) 2012-04-20 2017-05-15 Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos. (divisional solicitud 2831-2014)
CL2018003596A CL2018003596A1 (es) 2012-04-20 2018-12-14 Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos. (divisional solicitud 201402831)

Country Status (24)

Country Link
US (3) US9000187B2 (es)
EP (3) EP2895465B1 (es)
JP (4) JP6161173B2 (es)
KR (3) KR102160836B1 (es)
CN (4) CN107353254A (es)
AR (1) AR090766A1 (es)
AU (2) AU2013249217B2 (es)
BR (3) BR122015032742B1 (es)
CA (2) CA2870956C (es)
CL (3) CL2014002831A1 (es)
CO (1) CO7151497A2 (es)
EA (1) EA028430B1 (es)
ES (1) ES2703535T3 (es)
HK (1) HK1211580A1 (es)
IL (3) IL235107A (es)
MX (3) MX345971B (es)
NZ (3) NZ701185A (es)
PH (1) PH12014502345B1 (es)
PT (1) PT2895465T (es)
SG (3) SG11201406730RA (es)
UA (1) UA115981C2 (es)
UY (1) UY34761A (es)
WO (1) WO2013158894A1 (es)
ZA (1) ZA201407605B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2952857A1 (en) 2014-06-19 2015-12-23 Merial, Inc. Parasiticidal compositions comprising indole derivatives, methods and uses thereof
JP7080181B2 (ja) 2016-03-31 2022-06-03 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド シングル又はデュアルテクノロジー動物タグ及びシステム、並びにその使用方法
CN106496037A (zh) * 2016-10-20 2017-03-15 上海毕得医药科技有限公司 一种1,4‑二碘‑2‑甲氧基‑5‑硝基苯的合成方法
KR102147235B1 (ko) * 2018-05-18 2020-08-24 연세대학교 산학협력단 발광성, 강유전성 및 압전성을 나타내는 헤테로아릴 화합물 및 이를 포함하는 전자소자
GB201811695D0 (en) * 2018-07-17 2018-08-29 Salvensis Compounds for use in the treatment of fascioliasis
WO2024026359A1 (en) * 2022-07-26 2024-02-01 The Board Of Trustees Of The University Of Illinois Compounds and methods for the treatment of diseases associated with parasitic worms

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB955961A (en) * 1959-09-24 1964-04-22 Gevaert Photo Prod Nv Benzimidazole derivatives
NL277327A (es) * 1961-04-24
IL22272A (en) * 1963-11-06 1969-02-27 Merck & Co Inc 2-heteroaryl-5(or 6)-aryl substituted benzazoles
US3578675A (en) * 1969-06-09 1971-05-11 Merck & Co Inc 2-(3'-fluoro-2'-naphthyl)-benzimidazoles
US3749789A (en) * 1970-02-27 1973-07-31 Merck & Co Inc Anthelmintic compositions containing benzimidazoles and method of use
DE2016622A1 (en) * 1970-04-08 1971-10-21 Farbenfabriken Bayer Ag, 5090 Leverkusen Anthelmintic benzimidazole deriv
NL160809C (nl) 1970-05-15 1979-12-17 Duphar Int Res Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen.
JPS4914624A (es) 1972-06-08 1974-02-08
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
US3818047A (en) 1972-08-07 1974-06-18 C Henrick Substituted pyrones
US3815047A (en) 1973-02-14 1974-06-04 Bell Telephone Labor Inc Transversely-excited waveguide gas laser
US4336262A (en) 1973-02-23 1982-06-22 Fisons Ltd. Pour-on veterinary anthelmintic
DK645374A (es) * 1974-01-22 1975-09-29 Ciba Geigy Ag
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
CH604517A5 (es) 1976-08-19 1978-09-15 Ciba Geigy Ag
US4134973A (en) 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
US4205077A (en) 1977-04-12 1980-05-27 Ciba-Geigy Corporation Benzimidazole sulphides as anthelmintic agents
IL54474A (en) * 1977-04-12 1982-04-30 Ciba Geigy Ag Benzimidazole derivatives,their preparation and anthelmintic compositions containing them
US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4144352A (en) 1977-12-19 1979-03-13 Merck & Co., Inc. Milbemycin compounds as anthelmintic agents
US4203976A (en) 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
DE2840927A1 (de) * 1978-09-20 1980-04-10 Bayer Ag 3,4-dihydroisochinoline, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
CH642359A5 (en) * 1978-10-02 1984-04-13 Ciba Geigy Ag Benzimidazole derivatives
JPS57139012A (en) 1981-02-23 1982-08-27 Sankyo Co Ltd Anthelmintic composition
US4427663A (en) 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
JPS59199673A (ja) 1983-04-25 1984-11-12 Sumitomo Chem Co Ltd 含窒素複素環化合物、その製造法およびそれを有効成分とする有害生物防除剤
DE3580444D1 (en) 1984-10-18 1990-12-13 Ciba Geigy Ag Benzoylphenylharnstoffe.
ATE67493T1 (de) 1985-02-04 1991-10-15 Bayer Agrochem Kk Heterocyclische verbindungen.
EP0237482A1 (de) 1986-03-06 1987-09-16 Ciba-Geigy Ag C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen
EP0246739B1 (en) 1986-03-25 1991-01-23 Sankyo Company Limited Macrolide compounds, their preparation and their use
ES2039258T3 (es) 1986-07-02 1993-09-16 Ciba-Geigy Ag Pesticidas.
US4855317A (en) 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
US4871719A (en) 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
JPS6435773A (en) 1987-07-31 1989-02-06 Nippon Denki Home Electronics Signal frequency discriminating device
US4874749A (en) 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb
EP0319142B1 (en) 1987-11-03 1994-04-06 Beecham Group Plc Intermediates for the preparation of anthelmintic macrolide antibiotics
JP2695419B2 (ja) * 1987-11-20 1997-12-24 工業技術院長 ２−（ポリフルオロアルキル）ハロゲノベンズイミダゾール類、その製造法およびそれを有効成分とする殺虫、殺ダニ剤
NZ232422A (en) 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
NZ232785A (en) * 1989-03-15 1991-03-26 Janssen Pharmaceutica Nv 5-(1,2 benzisoxazol-, benzimidazol and benzisothiazol-3- yl)-1h-benzimadazol-2-yl carbamic acid ester derivatives preparatory processes, intermediates and anthelmintic compositions
IE904606A1 (en) 1989-12-21 1991-07-03 Beecham Group Plc Novel products
NZ247278A (en) 1991-02-12 1995-03-28 Ancare Distributors Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier
WO1992022555A1 (en) 1991-06-17 1992-12-23 Beecham Group Plc Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents
US5278181A (en) * 1992-05-12 1994-01-11 Board Of Regents Acting On Behalf Of The University Of Michigan Soluble alkyl[5-[amino (phenyl)methyl]-1H-benzimidazol-2-yl] carbamate anthelmintics
US5345377A (en) 1992-10-30 1994-09-06 Electric Power Research Institute, Inc. Harmonic controller for an active power line conditioner
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
US5399582A (en) 1993-11-01 1995-03-21 Merck & Co., Inc. Antiparasitic agents
AUPM969994A0 (en) 1994-11-28 1994-12-22 Virbac S.A. Equine anthelmintic formulations
US5962499A (en) 1995-03-20 1999-10-05 Merck & Co., Inc. Nodulisporic acid derivatives
US6221894B1 (en) 1995-03-20 2001-04-24 Merck & Co., Inc. Nodulisporic acid derivatives
MY113806A (en) 1995-07-21 2002-05-31 Upjohn Co Antiparasitic marcfortines and paraherquamides
IE80657B1 (en) 1996-03-29 1998-11-04 Merial Sas Insecticidal combination to control mammal fleas in particular fleas on cats and dogs
US6207647B1 (en) 1997-07-18 2001-03-27 Smithkline Beecham Corporation RatA
JPH1135773A (ja) * 1997-07-23 1999-02-09 Nippon Synthetic Chem Ind Co Ltd:The エチレン−酢酸ビニル系共重合体ケン化物組成物及び その成形物
PE20011289A1 (es) 2000-04-07 2001-12-21 Upjohn Co Composiciones antihelminticas que comprenden lactonas macrociclicas y espirodioxepinoindoles
US6399786B1 (en) 2000-07-14 2002-06-04 Merck & Co., Inc. Nonacyclic nodulisporic acid derivatives
TW200300140A (en) * 2001-11-14 2003-05-16 Novartis Ag Organic compounds
TW200409760A (en) 2002-09-11 2004-06-16 Novartis Ag Organic compounds
US7396819B2 (en) 2003-08-08 2008-07-08 Virbac Corporation Anthelmintic formulations
AU2005219788B2 (en) 2004-03-05 2010-06-03 Nissan Chemical Corporation Isoxazoline-substituted benzamide compound and noxious organism control agent
WO2006050148A2 (en) * 2004-10-29 2006-05-11 Teva Pharmaceutical Industries, Ltd. Propargyl trifluoromethoxy aminobenzimidazole derivatives
WO2006088246A1 (ja) * 2005-02-18 2006-08-24 Takeda Pharmaceutical Company Limited Ｇｐｒ３４受容体機能調節剤
KR20080080168A (ko) 2005-12-14 2008-09-02 이 아이 듀폰 디 네모아 앤드 캄파니 무척추 해충 방제용 이속사졸린
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
NZ573758A (en) * 2006-07-05 2012-01-12 Aventis Agriculture 1-Phenyl-3-cyano-pyrazole derivatives and pesticidal formulations containing them
JP2009023986A (ja) * 2006-11-08 2009-02-05 Pharma Ip 抗癌剤としてのビアリール誘導体
RU2009141185A (ru) 2007-04-10 2011-05-20 Байер КропСайенс АГ (DE) Инсектицидные производные арилизоксазолина
US8088801B2 (en) 2007-05-15 2012-01-03 Merial Limited Aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
NO2957284T3 (es) 2007-06-27 2018-06-16
US8440633B2 (en) 2007-06-29 2013-05-14 Ah Usa 42 Llc Anthelmintic combination
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
TW201111358A (en) * 2009-06-18 2011-04-01 Intervet Int Bv Anthelmintic agents and their use

Also Published As

Publication number Publication date
BR122015032741B1 (pt) 2019-11-26
EP3453702A2 (en) 2019-03-13
JP2016106154A (ja) 2016-06-16
CN105732511B (zh) 2018-08-17
CN107353254A (zh) 2017-11-17
BR122015032742B1 (pt) 2020-04-07
CL2018003596A1 (es) 2019-01-25
KR102114598B1 (ko) 2020-05-25
IL242980A (en) 2017-08-31
US9695129B2 (en) 2017-07-04
JP6124321B2 (ja) 2017-05-10
EA028430B1 (ru) 2017-11-30
WO2013158894A1 (en) 2013-10-24
US9359305B2 (en) 2016-06-07
PT2895465T (pt) 2019-01-16
EP2895465A1 (en) 2015-07-22
KR102160836B1 (ko) 2020-09-28
SG10201704665QA (en) 2017-07-28
IL251177A0 (en) 2017-05-29
CN105884693A (zh) 2016-08-24
JP2015516977A (ja) 2015-06-18
US20130281392A1 (en) 2013-10-24
MX345971B (es) 2017-02-28
CN105732511A (zh) 2016-07-06
SG10201700291VA (en) 2017-03-30
CO7151497A2 (es) 2014-12-29
KR20190114002A (ko) 2019-10-08
JP2017119716A (ja) 2017-07-06
AU2013249217B2 (en) 2017-04-27
KR20200000470A (ko) 2020-01-02
NZ709589A (en) 2015-10-30
NZ701185A (en) 2015-08-28
MX351636B (es) 2017-10-23
CA2870956C (en) 2020-03-31
ZA201407605B (en) 2015-11-25
SG11201406730RA (en) 2014-11-27
US9000187B2 (en) 2015-04-07
AU2013249217A1 (en) 2014-11-06
AR090766A1 (es) 2014-12-03
IL251177B (en) 2018-03-29
AU2017202719A1 (en) 2017-05-18
UY34761A (es) 2013-11-29
ES2703535T3 (es) 2019-03-11
US20160251317A1 (en) 2016-09-01
PH12014502345A1 (en) 2014-12-22
MX2014012713A (es) 2015-01-19
PH12014502345B1 (en) 2014-12-22
CA2870956A1 (en) 2013-10-24
US20150166485A1 (en) 2015-06-18
JP6246405B2 (ja) 2017-12-13
JP6161173B2 (ja) 2017-07-12
UA115981C2 (uk) 2018-01-25
NZ711847A (en) 2015-11-27
BR122015032742A2 (pt) 2018-12-11
CN105884693B (zh) 2019-11-01
JP6213852B2 (ja) 2017-10-18
BR112014026184A2 (pt) 2017-06-27
MX367536B (es) 2019-08-26
JP2016155837A (ja) 2016-09-01
KR20150002853A (ko) 2015-01-07
CN104395295B (zh) 2018-03-06
KR102160889B1 (ko) 2020-09-28
IL235107A (en) 2017-09-28
EP3453702A3 (en) 2019-05-15
EP2895465B1 (en) 2018-10-03
EP3763706A1 (en) 2021-01-13
EA201401160A1 (ru) 2015-04-30
BR112014026184B1 (pt) 2019-04-24
BR122015032741A2 (pt) 2019-08-27
CL2017001239A1 (es) 2017-12-11
HK1211580A1 (en) 2016-05-27
CA3059936A1 (en) 2013-10-24
CN104395295A (zh) 2015-03-04

Similar Documents

Publication Publication Date Title
CL2015000092A1 (es) Oligonucleótidos quiralmente controlados, composición que los comprende; método de elaboración: y uso para tratar cáncer.
CL2014003136A1 (es) Nuevos diazaespirocicloalcanos y azaespirocicloalcanos; composicion farmaceutica que los contiene y usos.
CL2015003280A1 (es) Derivados de benzimidazol como inhibidores de bromodominio
CR20140259A (es) Compuestos novedosos de benzopirano, composiciones y usos de los mismos
CL2015001157A1 (es) Composiciones y métodos para tratar proteinopatías.
CL2014002093A1 (es) Compuestos derivados piperidinopirimidinicos; composicion farmaceutica que los comprende; uso en el tratamiento de infecciones viricas.
CL2014002640A1 (es) Compuestos pirrolidin, piperidin o azepan sustituidos, inhibidores de met-ap2; procedimiento para prepararlos; y medicamento que los contiene.
CO7061071A2 (es) Procesos para la preparación de (s)-1-(3-etoxi-4-metoxifenil)-2-metansulfoniletilamina
CL2014001291A1 (es) Agentes de iarn de doble hebra; composiciones y metodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (ttr).
DK3229810T3 (da) Phospholipid-ether-analoger som kræftrammende lægemiddelvehikler
CL2014002831A1 (es) Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos para tratar infestacion por helmintos.
CL2014002756A1 (es) Compuestos derivados de 1,4-benzotiazepina; composición farmacéutica que lo comprende; uso para tratar afecciones relacionadas con función anormal de receptores de rianodina; y método de preparación del compuesto.
FI20126341A (fi) Menetelmä mikrofibrilloidun selluloosan valmistamiseksi, josta vesi on poistettu
GT201400017A (es) Derivados de piridin-2 (1h) -ona como inhibidores de jak
UY35747A (es) Derivados sustituidos de fenilalanina
CL2015001085A1 (es) Formulacion de liberación prolongada que comprende oprozomib y ademas uno o mas polimeros farmaceuticamente aceptables; metodo de preparacion de la formulacion; metodo para tratar cancer.
CL2014001862A1 (es) Compuestos derivados de morofolinilo sustituido, útiles como inhibidores de mogat-2; composicion farmaceutica que los comprende; uso en el tratamiento de hipertrigliceridemia.
BR112015005789A2 (pt) Formulações que compreende idebenona, n-acetil- s-farnesil-l-cisteína e ergotioneína e usos das mesmas
CL2014002951A1 (es) (r)-nifuratel; formulacion farmaceutica que lo contiene; y proceso para fabricar (r)-nifuratel y (s)-nifuratel.
CL2014001127A1 (es) Metodos y composicion de fumigante que comprende hexafluoropropeno, 1,1,3,3,3-pentafluoropropeno o combinacion de los mismos.
BR112016002560A2 (pt) derivados de pirrolona usados como herbicidas.
CL2015000884A1 (es) Compuestos de pirona y herbicidas que comprenden los mismos.
DK2851075T3 (da) Præparat, der indeholder 6,7-umættet -7-carbamoylmorphinanderivat
BR112016012233A2 (pt) composições compreendendo cinamaldeído, e seus usos
CL2014002033A1 (es) Compuestos derivados de dihidrofurano-azetidina y sus sales; composicion farmaceutica o veterinaria que los comprende; y su uso para tratar una infeccion o infestacion parasitaria.