CL2014000159A1 - Copolimeros multibloque termoplasticos biodegradables para la liberacion controlada de compuestos biologicamente activos; proceso de preparacion de dicho copolimero; composicion para suministro de compuesto biologicamente activo a un hospedero; y metodo para suministrar dicho compuesto. - Google Patents

Copolimeros multibloque termoplasticos biodegradables para la liberacion controlada de compuestos biologicamente activos; proceso de preparacion de dicho copolimero; composicion para suministro de compuesto biologicamente activo a un hospedero; y metodo para suministrar dicho compuesto.

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Publication number
CL2014000159A1
CL2014000159A1 CL2014000159A CL2014000159A CL2014000159A1 CL 2014000159 A1 CL2014000159 A1 CL 2014000159A1 CL 2014000159 A CL2014000159 A CL 2014000159A CL 2014000159 A CL2014000159 A CL 2014000159A CL 2014000159 A1 CL2014000159 A1 CL 2014000159A1
Authority
CL
Chile
Prior art keywords
biologically active
compound
deliver
copolymer
host
Prior art date
Application number
CL2014000159A
Other languages
English (en)
Spanish (es)
Inventor
Rob Steendam
Theodorus Adrianus Cornelius Flipsen
Christine Hiemstra
Johan Zuidema
Original Assignee
Innocore Technologies B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innocore Technologies B V filed Critical Innocore Technologies B V
Publication of CL2014000159A1 publication Critical patent/CL2014000159A1/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
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CL2014000159A 2011-07-22 2014-01-21 Copolimeros multibloque termoplasticos biodegradables para la liberacion controlada de compuestos biologicamente activos; proceso de preparacion de dicho copolimero; composicion para suministro de compuesto biologicamente activo a un hospedero; y metodo para suministrar dicho compuesto. CL2014000159A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11174987 2011-07-22

Publications (1)

Publication Number Publication Date
CL2014000159A1 true CL2014000159A1 (es) 2014-08-29

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CL2014000159A CL2014000159A1 (es) 2011-07-22 2014-01-21 Copolimeros multibloque termoplasticos biodegradables para la liberacion controlada de compuestos biologicamente activos; proceso de preparacion de dicho copolimero; composicion para suministro de compuesto biologicamente activo a un hospedero; y metodo para suministrar dicho compuesto.

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Country Link
US (2) US20140199385A1 (enExample)
EP (1) EP2734573B1 (enExample)
JP (2) JP6174023B2 (enExample)
KR (1) KR101889586B1 (enExample)
CN (1) CN103827177B (enExample)
AU (1) AU2012287577B2 (enExample)
BR (1) BR112014001441A2 (enExample)
CA (1) CA2842514C (enExample)
CL (1) CL2014000159A1 (enExample)
CO (1) CO7020923A2 (enExample)
ES (1) ES2899701T3 (enExample)
IL (1) IL230606B (enExample)
MX (1) MX362941B (enExample)
MY (1) MY169349A (enExample)
PH (1) PH12014500192A1 (enExample)
RU (2) RU2662818C2 (enExample)
UA (1) UA112192C2 (enExample)
WO (1) WO2013015685A1 (enExample)
ZA (1) ZA201400846B (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6174023B2 (ja) * 2011-07-22 2017-08-02 インノコア テクノロジーズ ビー．ブイ． 生物活性化合物の制御放出のための生物分解性、半結晶性、相分離、熱可塑性マルチブロックコポリマー
CN104107434B (zh) * 2013-04-18 2017-02-01 山东绿叶制药有限公司 戈舍瑞林缓释微球药物组合物
JO3394B1 (ar) 2014-07-04 2019-10-20 Osteo Pharma B V تركيبات ومنتجات للاستعمال في علاج كسور وعيوب العظام
CN105273153A (zh) * 2014-07-24 2016-01-27 允友成(宿迁)复合新材料有限公司 一种可降解生物基水性乳液及其制备方法
CN105273154A (zh) * 2014-07-24 2016-01-27 允友成(宿迁)复合新材料有限公司 一种可降解聚乳酸基水性乳液及其制备方法
CA2957966C (en) * 2014-08-14 2021-11-30 Brown University Compositions for stabilizing and delivering proteins
EP3218022A1 (en) 2014-11-14 2017-09-20 University College Cork, National University Of Ireland Delivery of igf-1 in myocardial infarction
KR102009972B1 (ko) * 2015-11-25 2019-10-21 주식회사 엘지화학 양친성 고분자
KR102001614B1 (ko) * 2015-11-25 2019-07-18 주식회사 엘지화학 양친성 고분자
CN105461884B (zh) * 2015-12-22 2018-05-29 佛山市顺德区福利来酒店傢具有限公司 儿童抗菌耐划伤家具及其制备方法
AU2016377694A1 (en) 2015-12-22 2018-07-12 Access Vascular, Inc. High strength biomedical materials
WO2017217817A1 (ko) * 2016-06-16 2017-12-21 주식회사 엘지화학 양친성 트리블록 고분자
JP6887713B2 (ja) 2016-06-16 2021-06-16 エルジー・ケム・リミテッド 両親媒性高分子
WO2017217813A1 (ko) * 2016-06-16 2017-12-21 주식회사 엘지화학 양친성 고분자
AU2018217064A1 (en) 2017-01-31 2019-08-08 Veru Inc. Compositions and methods for long term release of Gonadotropin-releasing hormone (GnRH) antagonists
CN107376026B (zh) * 2017-07-15 2019-03-19 深圳市立心科学有限公司 可吸收的生物医用复合材料及其制备方法
CA3077037C (en) 2017-10-04 2024-01-23 Fashion Chemicals Gmbh & Co. Kg Esters of polylactic acid and compositions thereof
US12421355B2 (en) 2018-03-30 2025-09-23 Toray Industries, Inc. Biodegradable block copolymer
CN108387664B (zh) * 2018-07-03 2020-06-23 中国食品药品检定研究院 人血白蛋白分子大小分布超高效液相色谱测定方法
WO2020071912A1 (en) 2018-10-02 2020-04-09 Innocore Technologies B.V. Extended release formulations of human chorionic gonadotropin (hcg)
US12194198B2 (en) * 2018-12-19 2025-01-14 Access Vascular, Inc. High strength porous materials for controlled release
US20220184214A1 (en) * 2019-03-28 2022-06-16 Pk Med Multicomponent thermoplastic product
US20210017329A1 (en) * 2019-07-19 2021-01-21 Evonik Operations Gmbh Multi-block shape memory bioresorbable polymers
US20220331258A1 (en) 2019-10-01 2022-10-20 Allergan Sales, Llc Poly-Dioxanone Multi-Block Copolymer for Ocular Protein Delivery
AU2020357419B2 (en) * 2019-10-01 2025-12-04 InnoCore Technologies Holding B.V. Biodegradable, phase separated, thermoplastic multi-block copolymer
HUE065507T2 (hu) * 2019-10-31 2024-05-28 Evonik Operations Gmbh Eljárás hordozó polimerbõl és egy vagy több, biológiailag aktív összetevõbõl álló nano- vagy mikrorészecskék elõállítására
US20220409730A1 (en) * 2019-11-01 2022-12-29 InnoCore Technologies Holding B.V. Dosage form for extended release of an antibody or large protein
EP4072607A4 (en) * 2019-12-12 2024-01-10 Massachusetts Eye and Ear Infirmary MELT EXTRUDABLE 3D PRINTING INKS
CN115443174B (zh) * 2020-02-21 2024-04-26 自然工作有限责任公司 含有低分子量无定形级聚乳酸树脂的化妆品组合物
WO2021207737A2 (en) * 2020-04-10 2021-10-14 Scienture, Inc. Long-acting apomorphine formulations and injectors for therapeutic delivery of the same
EP4138783A4 (en) 2020-04-22 2024-04-10 Scienture, Inc. LONG-ACTING BUPIVACAIN MICROSPHERE FORMULATIONS
CN111484635B (zh) * 2020-06-10 2023-09-12 杭州铭善生物科技有限公司 一种温敏性水凝胶材料的改性方法、改性温敏性水凝胶材料和生物3d打印墨水
CN112336689B (zh) * 2020-10-30 2022-06-28 浙江大学衢州研究院 一种结晶性嵌段共聚物胶束制备多重Pickering乳液的方法
EP4281044A1 (en) * 2021-01-22 2023-11-29 University of Connecticut Synthetic artificial stem cells (sasc)
US12186722B2 (en) 2022-02-07 2025-01-07 Honeywell Federal Manufacturing & Technologies, Llc Porous polysiloxane microspheres
CN114737276B (zh) * 2022-03-11 2023-02-07 北京朗净汇明生物科技有限公司 一种耐热抗水解型聚乳酸纤维及其制备方法
WO2023177300A1 (en) 2022-03-17 2023-09-21 InnoCore Technologies Holding B.V. Biodegradable thermoplastic poly(ortho ester) based multiblock copolymers

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4429080A (en) 1982-07-01 1984-01-31 American Cyanamid Company Synthetic copolymer surgical articles and method of manufacturing the same
US5066772A (en) 1987-12-17 1991-11-19 Allied-Signal Inc. Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides
US5133739A (en) 1990-02-06 1992-07-28 Ethicon, Inc. Segmented copolymers of ε-caprolactone and glycolide
CN1037612C (zh) * 1992-07-20 1998-03-04 中国科学院化学研究所 热致形状可回复性多嵌段聚合物材料
US5236444A (en) 1992-10-27 1993-08-17 United States Surgical Corporation Absorbable polymers and surgical articles made therefrom
DE69432459T2 (de) * 1993-01-06 2003-11-27 Kinerton Ltd., Blanchardstown Ionische molekularkonjugate von bioabbaubaren polyestern und bioaktiven polypeptiden
US5403347A (en) 1993-05-27 1995-04-04 United States Surgical Corporation Absorbable block copolymers and surgical articles fabricated therefrom
US5711958A (en) 1996-07-11 1998-01-27 Life Medical Sciences, Inc. Methods for reducing or eliminating post-surgical adhesion formation
US5980948A (en) 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
US6211249B1 (en) 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
AU751861B2 (en) 1998-02-23 2002-08-29 Massachusetts Institute Of Technology Biodegradable shape memory polymers
US8158143B2 (en) 2000-07-14 2012-04-17 Helmholtz-Zentrum Geesthacht Zentrum Fuer Material- Und Kuestenforschung Gmbh Systems for releasing active ingredients, based on biodegradable or biocompatible polymers with a shape memory effect
EP1382628A1 (en) * 2002-07-16 2004-01-21 Polyganics B.V. Biodegradable phase separated segmented/block co-polyesters
EP1555278A1 (en) * 2004-01-15 2005-07-20 Innocore Technologies B.V. Biodegradable multi-block co-polymers
US20090004243A1 (en) * 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
JP6174023B2 (ja) * 2011-07-22 2017-08-02 インノコア テクノロジーズ ビー．ブイ． 生物活性化合物の制御放出のための生物分解性、半結晶性、相分離、熱可塑性マルチブロックコポリマー

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