IL230606B - Thermoplastic, semi-crystalline and biodegradable co-polymers in a biological environment and their use for the preparation of preparations for the controlled release of biologically active substances - Google Patents

Thermoplastic, semi-crystalline and biodegradable co-polymers in a biological environment and their use for the preparation of preparations for the controlled release of biologically active substances

Info

Publication number
IL230606B
IL230606B IL230606A IL23060614A IL230606B IL 230606 B IL230606 B IL 230606B IL 230606 A IL230606 A IL 230606A IL 23060614 A IL23060614 A IL 23060614A IL 230606 B IL230606 B IL 230606B
Authority
IL
Israel
Prior art keywords
biodegradable
crystalline
semi
biologically active
controlled release
Prior art date
Application number
IL230606A
Other languages
English (en)
Hebrew (he)
Other versions
IL230606A0 (en
Inventor
Steendam Rob
Adrianus Cornelius Flipsen Theodorus
Hiemstra Christine
Zuidema Johan
Original Assignee
Innocore Tech B V
Steendam Rob
Adrianus Cornelius Flipsen Theodorus
Hiemstra Christine
Zuidema Johan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innocore Tech B V, Steendam Rob, Adrianus Cornelius Flipsen Theodorus, Hiemstra Christine, Zuidema Johan filed Critical Innocore Tech B V
Publication of IL230606A0 publication Critical patent/IL230606A0/en
Publication of IL230606B publication Critical patent/IL230606B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/668—Polyesters containing oxygen in the form of ether groups derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/672—Dicarboxylic acids and dihydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/16—Compositions of unspecified macromolecular compounds the macromolecular compounds being biodegradable
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L87/00—Compositions of unspecified macromolecular compounds, obtained otherwise than by polymerisation reactions only involving unsaturated carbon-to-carbon bonds
    • C08L87/005—Block or graft polymers not provided for in groups C08L1/00 - C08L85/04
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/38—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group
    • C08G2650/42—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group containing orthoester groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
IL230606A 2011-07-22 2014-01-22 Thermoplastic, semi-crystalline and biodegradable co-polymers in a biological environment and their use for the preparation of preparations for the controlled release of biologically active substances IL230606B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11174987 2011-07-22
PCT/NL2012/050529 WO2013015685A1 (en) 2011-07-22 2012-07-23 Biodegradable, semi-crystalline, phase separated, thermoplastic multi block copolymers for controlled release of biologically active compounds

Publications (2)

Publication Number Publication Date
IL230606A0 IL230606A0 (en) 2014-03-31
IL230606B true IL230606B (en) 2019-07-31

Family

ID=46704994

Family Applications (1)

Application Number Title Priority Date Filing Date
IL230606A IL230606B (en) 2011-07-22 2014-01-22 Thermoplastic, semi-crystalline and biodegradable co-polymers in a biological environment and their use for the preparation of preparations for the controlled release of biologically active substances

Country Status (19)

Country Link
US (2) US20140199385A1 (enExample)
EP (1) EP2734573B1 (enExample)
JP (2) JP6174023B2 (enExample)
KR (1) KR101889586B1 (enExample)
CN (1) CN103827177B (enExample)
AU (1) AU2012287577B2 (enExample)
BR (1) BR112014001441A2 (enExample)
CA (1) CA2842514C (enExample)
CL (1) CL2014000159A1 (enExample)
CO (1) CO7020923A2 (enExample)
ES (1) ES2899701T3 (enExample)
IL (1) IL230606B (enExample)
MX (1) MX362941B (enExample)
MY (1) MY169349A (enExample)
PH (1) PH12014500192A1 (enExample)
RU (2) RU2662818C2 (enExample)
UA (1) UA112192C2 (enExample)
WO (1) WO2013015685A1 (enExample)
ZA (1) ZA201400846B (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6174023B2 (ja) * 2011-07-22 2017-08-02 インノコア テクノロジーズ ビー．ブイ． 生物活性化合物の制御放出のための生物分解性、半結晶性、相分離、熱可塑性マルチブロックコポリマー
CN104107434B (zh) * 2013-04-18 2017-02-01 山东绿叶制药有限公司 戈舍瑞林缓释微球药物组合物
JO3394B1 (ar) 2014-07-04 2019-10-20 Osteo Pharma B V تركيبات ومنتجات للاستعمال في علاج كسور وعيوب العظام
CN105273153A (zh) * 2014-07-24 2016-01-27 允友成(宿迁)复合新材料有限公司 一种可降解生物基水性乳液及其制备方法
CN105273154A (zh) * 2014-07-24 2016-01-27 允友成(宿迁)复合新材料有限公司 一种可降解聚乳酸基水性乳液及其制备方法
CA2957966C (en) * 2014-08-14 2021-11-30 Brown University Compositions for stabilizing and delivering proteins
EP3218022A1 (en) 2014-11-14 2017-09-20 University College Cork, National University Of Ireland Delivery of igf-1 in myocardial infarction
KR102009972B1 (ko) * 2015-11-25 2019-10-21 주식회사 엘지화학 양친성 고분자
KR102001614B1 (ko) * 2015-11-25 2019-07-18 주식회사 엘지화학 양친성 고분자
CN105461884B (zh) * 2015-12-22 2018-05-29 佛山市顺德区福利来酒店傢具有限公司 儿童抗菌耐划伤家具及其制备方法
AU2016377694A1 (en) 2015-12-22 2018-07-12 Access Vascular, Inc. High strength biomedical materials
WO2017217817A1 (ko) * 2016-06-16 2017-12-21 주식회사 엘지화학 양친성 트리블록 고분자
JP6887713B2 (ja) 2016-06-16 2021-06-16 エルジー・ケム・リミテッド 両親媒性高分子
WO2017217813A1 (ko) * 2016-06-16 2017-12-21 주식회사 엘지화학 양친성 고분자
AU2018217064A1 (en) 2017-01-31 2019-08-08 Veru Inc. Compositions and methods for long term release of Gonadotropin-releasing hormone (GnRH) antagonists
CN107376026B (zh) * 2017-07-15 2019-03-19 深圳市立心科学有限公司 可吸收的生物医用复合材料及其制备方法
CA3077037C (en) 2017-10-04 2024-01-23 Fashion Chemicals Gmbh & Co. Kg Esters of polylactic acid and compositions thereof
US12421355B2 (en) 2018-03-30 2025-09-23 Toray Industries, Inc. Biodegradable block copolymer
CN108387664B (zh) * 2018-07-03 2020-06-23 中国食品药品检定研究院 人血白蛋白分子大小分布超高效液相色谱测定方法
WO2020071912A1 (en) 2018-10-02 2020-04-09 Innocore Technologies B.V. Extended release formulations of human chorionic gonadotropin (hcg)
US12194198B2 (en) * 2018-12-19 2025-01-14 Access Vascular, Inc. High strength porous materials for controlled release
US20220184214A1 (en) * 2019-03-28 2022-06-16 Pk Med Multicomponent thermoplastic product
US20210017329A1 (en) * 2019-07-19 2021-01-21 Evonik Operations Gmbh Multi-block shape memory bioresorbable polymers
US20220331258A1 (en) 2019-10-01 2022-10-20 Allergan Sales, Llc Poly-Dioxanone Multi-Block Copolymer for Ocular Protein Delivery
AU2020357419B2 (en) * 2019-10-01 2025-12-04 InnoCore Technologies Holding B.V. Biodegradable, phase separated, thermoplastic multi-block copolymer
HUE065507T2 (hu) * 2019-10-31 2024-05-28 Evonik Operations Gmbh Eljárás hordozó polimerbõl és egy vagy több, biológiailag aktív összetevõbõl álló nano- vagy mikrorészecskék elõállítására
US20220409730A1 (en) * 2019-11-01 2022-12-29 InnoCore Technologies Holding B.V. Dosage form for extended release of an antibody or large protein
EP4072607A4 (en) * 2019-12-12 2024-01-10 Massachusetts Eye and Ear Infirmary MELT EXTRUDABLE 3D PRINTING INKS
CN115443174B (zh) * 2020-02-21 2024-04-26 自然工作有限责任公司 含有低分子量无定形级聚乳酸树脂的化妆品组合物
WO2021207737A2 (en) * 2020-04-10 2021-10-14 Scienture, Inc. Long-acting apomorphine formulations and injectors for therapeutic delivery of the same
EP4138783A4 (en) 2020-04-22 2024-04-10 Scienture, Inc. LONG-ACTING BUPIVACAIN MICROSPHERE FORMULATIONS
CN111484635B (zh) * 2020-06-10 2023-09-12 杭州铭善生物科技有限公司 一种温敏性水凝胶材料的改性方法、改性温敏性水凝胶材料和生物3d打印墨水
CN112336689B (zh) * 2020-10-30 2022-06-28 浙江大学衢州研究院 一种结晶性嵌段共聚物胶束制备多重Pickering乳液的方法
EP4281044A1 (en) * 2021-01-22 2023-11-29 University of Connecticut Synthetic artificial stem cells (sasc)
US12186722B2 (en) 2022-02-07 2025-01-07 Honeywell Federal Manufacturing & Technologies, Llc Porous polysiloxane microspheres
CN114737276B (zh) * 2022-03-11 2023-02-07 北京朗净汇明生物科技有限公司 一种耐热抗水解型聚乳酸纤维及其制备方法
WO2023177300A1 (en) 2022-03-17 2023-09-21 InnoCore Technologies Holding B.V. Biodegradable thermoplastic poly(ortho ester) based multiblock copolymers

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4429080A (en) 1982-07-01 1984-01-31 American Cyanamid Company Synthetic copolymer surgical articles and method of manufacturing the same
US5066772A (en) 1987-12-17 1991-11-19 Allied-Signal Inc. Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides
US5133739A (en) 1990-02-06 1992-07-28 Ethicon, Inc. Segmented copolymers of ε-caprolactone and glycolide
CN1037612C (zh) * 1992-07-20 1998-03-04 中国科学院化学研究所 热致形状可回复性多嵌段聚合物材料
US5236444A (en) 1992-10-27 1993-08-17 United States Surgical Corporation Absorbable polymers and surgical articles made therefrom
DE69432459T2 (de) * 1993-01-06 2003-11-27 Kinerton Ltd., Blanchardstown Ionische molekularkonjugate von bioabbaubaren polyestern und bioaktiven polypeptiden
US5403347A (en) 1993-05-27 1995-04-04 United States Surgical Corporation Absorbable block copolymers and surgical articles fabricated therefrom
US5711958A (en) 1996-07-11 1998-01-27 Life Medical Sciences, Inc. Methods for reducing or eliminating post-surgical adhesion formation
US5980948A (en) 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
US6211249B1 (en) 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
AU751861B2 (en) 1998-02-23 2002-08-29 Massachusetts Institute Of Technology Biodegradable shape memory polymers
US8158143B2 (en) 2000-07-14 2012-04-17 Helmholtz-Zentrum Geesthacht Zentrum Fuer Material- Und Kuestenforschung Gmbh Systems for releasing active ingredients, based on biodegradable or biocompatible polymers with a shape memory effect
EP1382628A1 (en) * 2002-07-16 2004-01-21 Polyganics B.V. Biodegradable phase separated segmented/block co-polyesters
EP1555278A1 (en) * 2004-01-15 2005-07-20 Innocore Technologies B.V. Biodegradable multi-block co-polymers
US20090004243A1 (en) * 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
JP6174023B2 (ja) * 2011-07-22 2017-08-02 インノコア テクノロジーズ ビー．ブイ． 生物活性化合物の制御放出のための生物分解性、半結晶性、相分離、熱可塑性マルチブロックコポリマー

Also Published As

Publication number Publication date
CA2842514C (en) 2018-12-18
CA2842514A1 (en) 2013-01-31
BR112014001441A2 (pt) 2019-05-14
KR101889586B1 (ko) 2018-09-20
PH12014500192A1 (en) 2014-03-24
US10300019B2 (en) 2019-05-28
CL2014000159A1 (es) 2014-08-29
AU2012287577B2 (en) 2017-02-16
EP2734573B1 (en) 2021-09-08
JP2017141477A (ja) 2017-08-17
MX362941B (es) 2019-02-27
CN103827177B (zh) 2016-02-10
KR20140048296A (ko) 2014-04-23
CO7020923A2 (es) 2014-08-11
CN103827177A (zh) 2014-05-28
UA112192C2 (uk) 2016-08-10
JP6174023B2 (ja) 2017-08-02
RU2014102900A (ru) 2015-08-27
EP2734573A1 (en) 2014-05-28
MY169349A (en) 2019-03-21
RU2018125698A (ru) 2019-03-13
JP2014521762A (ja) 2014-08-28
RU2662818C2 (ru) 2018-07-31
ES2899701T3 (es) 2022-03-14
US20140199385A1 (en) 2014-07-17
AU2012287577A1 (en) 2014-03-13
NZ620392A (en) 2016-02-26
WO2013015685A1 (en) 2013-01-31
MX2014000891A (es) 2015-05-11
ZA201400846B (en) 2016-08-31
IL230606A0 (en) 2014-03-31
US20180085318A1 (en) 2018-03-29
JP6472836B2 (ja) 2019-02-20

Similar Documents

Publication Publication Date Title
ZA201400846B (en) Biodegradable, semi-crystalline, phase separated, thermoplastic multi block copolymers for controlled release of biologically active compounds
PL2588288T3 (pl) Proces wytwarzania powłok z siatek włókninowych
BR112013021368A2 (pt) implante, especialmente para oclusão de abeurismas bifurcais
ZA201109445B (en) Hot-melt extruded controlled release dosage form
ZA201207552B (en) Microporous material
EP2680771A4 (en) REMOVABLE CAGE FOR BONE CONNECTION
GB201117796D0 (en) Polymeric materials
ZA201309653B (en) Controlled release peptide formulations
SG11201503213PA (en) Polypropylene for microporous film
PL2748251T3 (pl) Kompozycja polipropylenowa do spieniania
EP2700678A4 (en) BIODEGRADABLE POLYMER COMPOSITE MATERIAL
IL223657A (en) Reliable mammogram systems
EP2554168A4 (en) PHARMACEUTICAL COMPOSITION WITH CONTROLLED RELEASE
GB201122285D0 (en) Switching control systems
PT2734581T (pt) Materiais poliméricos
ZA201305196B (en) Soil release polymers
ZA201303862B (en) Absorbent article having releasable odor control
GB201109755D0 (en) Polymeric materials
ZA201307557B (en) Polymeric materials
SG11201400281PA (en) Biocompatible material
EP2580282A4 (en) MODIFIED POLYPROPYLENE FOR PACKAGING APPLICATIONS
GB201222287D0 (en) Methods for making active crystalline materials
PL2425803T3 (pl) System do tworzenia artykułu absorpcyjnego
GB201117633D0 (en) Polymeric materials
EP2575820A4 (en) PHARMACEUTICAL FORM WITH CONTROLLED RELEASE WITH QUETIAPIN

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed