AU2012287577B2 - Biodegradable, semi-crystalline, phase separated, thermoplastic multi block copolymers for controlled release of biologically active compounds - Google Patents

Biodegradable, semi-crystalline, phase separated, thermoplastic multi block copolymers for controlled release of biologically active compounds Download PDF

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Publication number
AU2012287577B2
AU2012287577B2 AU2012287577A AU2012287577A AU2012287577B2 AU 2012287577 B2 AU2012287577 B2 AU 2012287577B2 AU 2012287577 A AU2012287577 A AU 2012287577A AU 2012287577 A AU2012287577 A AU 2012287577A AU 2012287577 B2 AU2012287577 B2 AU 2012287577B2
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polymer
microspheres
biologically active
block copolymer
crystalline
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AU2012287577A1 (en
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Theodorus Adrianus Cornelius Flipsen
Christine Hiemstra
Rob Steendam
Johan Zuidema
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Innocore Technologies Holding BV
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Innocore Technologies Holding BV
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • C08G2650/42—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group containing orthoester groups

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  • Diabetes (AREA)
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  • Neurology (AREA)
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  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
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  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
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AU2012287577A 2011-07-22 2012-07-23 Biodegradable, semi-crystalline, phase separated, thermoplastic multi block copolymers for controlled release of biologically active compounds Active AU2012287577B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11174987.5 2011-07-22
EP11174987 2011-07-22
PCT/NL2012/050529 WO2013015685A1 (en) 2011-07-22 2012-07-23 Biodegradable, semi-crystalline, phase separated, thermoplastic multi block copolymers for controlled release of biologically active compounds

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AU2012287577A1 AU2012287577A1 (en) 2014-03-13
AU2012287577B2 true AU2012287577B2 (en) 2017-02-16

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AU2012287577A Active AU2012287577B2 (en) 2011-07-22 2012-07-23 Biodegradable, semi-crystalline, phase separated, thermoplastic multi block copolymers for controlled release of biologically active compounds

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US (2) US20140199385A1 (enExample)
EP (1) EP2734573B1 (enExample)
JP (2) JP6174023B2 (enExample)
KR (1) KR101889586B1 (enExample)
CN (1) CN103827177B (enExample)
AU (1) AU2012287577B2 (enExample)
BR (1) BR112014001441A2 (enExample)
CA (1) CA2842514C (enExample)
CL (1) CL2014000159A1 (enExample)
CO (1) CO7020923A2 (enExample)
ES (1) ES2899701T3 (enExample)
IL (1) IL230606B (enExample)
MX (1) MX362941B (enExample)
MY (1) MY169349A (enExample)
PH (1) PH12014500192A1 (enExample)
RU (2) RU2662818C2 (enExample)
UA (1) UA112192C2 (enExample)
WO (1) WO2013015685A1 (enExample)
ZA (1) ZA201400846B (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2842514C (en) * 2011-07-22 2018-12-18 Innocore Technologies B.V. Biodegradable, semi-crystalline, phase separated, thermoplastic multi-block copolymers for controlled release of biologically active compounds
RU2694901C2 (ru) * 2013-04-18 2019-07-18 Шаньдун Луе Фармасьютикал Ко., Лтд Фармацевтические композиции микросфер гозерелина с пролонгированным высвобождением
JO3394B1 (ar) 2014-07-04 2019-10-20 Osteo Pharma B V تركيبات ومنتجات للاستعمال في علاج كسور وعيوب العظام
CN105273153A (zh) * 2014-07-24 2016-01-27 允友成(宿迁)复合新材料有限公司 一种可降解生物基水性乳液及其制备方法
CN105273154A (zh) * 2014-07-24 2016-01-27 允友成(宿迁)复合新材料有限公司 一种可降解聚乳酸基水性乳液及其制备方法
CA2957966C (en) * 2014-08-14 2021-11-30 Brown University Compositions for stabilizing and delivering proteins
WO2016075304A1 (en) 2014-11-14 2016-05-19 University College Cork - National University Of Ireland, Cork Delivery of igf-1 in myocardial infarction
KR102001614B1 (ko) * 2015-11-25 2019-07-18 주식회사 엘지화학 양친성 고분자
KR102009972B1 (ko) * 2015-11-25 2019-10-21 주식회사 엘지화학 양친성 고분자
CN105461884B (zh) * 2015-12-22 2018-05-29 佛山市顺德区福利来酒店傢具有限公司 儿童抗菌耐划伤家具及其制备方法
DK3393537T3 (da) 2015-12-22 2024-08-26 Access Vascular Inc Biomedicinske materialer med høj styrke
CN109153758B (zh) 2016-06-16 2021-04-27 株式会社Lg化学 两亲性三嵌段聚合物
JP6887713B2 (ja) 2016-06-16 2021-06-16 エルジー・ケム・リミテッド 両親媒性高分子
WO2017217813A1 (ko) * 2016-06-16 2017-12-21 주식회사 엘지화학 양친성 고분자
EP3576771B1 (en) 2017-01-31 2022-03-09 Veru Inc. Compositions and methods for long term release of ganadotropin-releasing hormone (gnrh) antagonists
CN107376026B (zh) * 2017-07-15 2019-03-19 深圳市立心科学有限公司 可吸收的生物医用复合材料及其制备方法
CA3077037C (en) * 2017-10-04 2024-01-23 Fashion Chemicals Gmbh & Co. Kg Esters of polylactic acid and compositions thereof
RU2020132481A (ru) * 2018-03-30 2022-05-04 Торэй Индастриз, Инк. Биоразлагаемый блок-сополимер
CN108387664B (zh) * 2018-07-03 2020-06-23 中国食品药品检定研究院 人血白蛋白分子大小分布超高效液相色谱测定方法
BR112021006406A2 (pt) * 2018-10-02 2021-07-06 Innocore Tech Holding B V forma de dosagem de gonadotrofina coriônica humana (hcg) de liberação prolongada
CN113557008A (zh) 2018-10-29 2021-10-26 弗劳恩霍夫应用研究促进协会 具有持续活性的四环素类络合物
AU2019404045A1 (en) * 2018-12-19 2021-06-24 Access Vascular, Inc. High strength porous materials for controlled release
MX2021011681A (es) * 2019-03-28 2022-01-04 Pk Med Producto termoplastico multicomponente.
US20210017329A1 (en) * 2019-07-19 2021-01-21 Evonik Operations Gmbh Multi-block shape memory bioresorbable polymers
CA3156256A1 (en) * 2019-10-01 2021-04-08 InnoCore Technologies Holding B.V. Biodegradable, phase separated, thermoplastic multi-block copolymer
WO2021067388A1 (en) 2019-10-01 2021-04-08 Allergan Sales, Llc Poly-dioxanone multi-block copolymer for ocular protein delivery
IL294641B2 (en) * 2019-10-31 2024-11-01 Evonik Operations Gmbh A process for preparing nanoparticles or microparticles containing a carrier polymer and one or more biologically active components
EP4051233A1 (en) 2019-11-01 2022-09-07 InnoCore Technologies Holding B.V. Dosage form for extended release of an antibody or large protein
WO2021119501A1 (en) * 2019-12-12 2021-06-17 Massachusetts Eye And Ear Infirmary Melt-extrudable 3d printing inks
WO2021168170A1 (en) * 2020-02-21 2021-08-26 Natureworks Llc Cosmetic compositions containing low molecular weight amorphous grade polylactic acid resin
WO2021178785A1 (en) 2020-03-06 2021-09-10 Access Vascular, Inc. Packaging for hydrated articles and related methods
JP2023522134A (ja) * 2020-04-10 2023-05-26 サイエンチュア, インコーポレイテッド 長時間作用型アポモルフィン製剤、およびその治療送達用のインジェクター
CA3180971A1 (en) 2020-04-22 2021-10-28 Scienture, Inc. Long-acting bupivacaine microsphere formulations
CN111484635B (zh) * 2020-06-10 2023-09-12 杭州铭善生物科技有限公司 一种温敏性水凝胶材料的改性方法、改性温敏性水凝胶材料和生物3d打印墨水
CN112336689B (zh) * 2020-10-30 2022-06-28 浙江大学衢州研究院 一种结晶性嵌段共聚物胶束制备多重Pickering乳液的方法
WO2022159658A1 (en) * 2021-01-22 2022-07-28 University Of Connecticut Synthetic artificial stem cells (sasc)
US12186722B2 (en) 2022-02-07 2025-01-07 Honeywell Federal Manufacturing & Technologies, Llc Porous polysiloxane microspheres
CN114737276B (zh) * 2022-03-11 2023-02-07 北京朗净汇明生物科技有限公司 一种耐热抗水解型聚乳酸纤维及其制备方法
KR20250005106A (ko) 2022-03-17 2025-01-09 이노코어 테크놀로지스 홀딩 비.브이. 생분해성 열가소성 폴리(오르토 에스테르)에 기반한 다중블록 공중합체
WO2026015019A1 (en) 2024-07-08 2026-01-15 InnoCore Technologies Holding B.V. Biodegradable thermoplastic polyoxazoline based copolymers
US12514756B1 (en) 2024-10-08 2026-01-06 Covidien Lp Dermal patch and systems, kits, and methods associated therewith
DE102024129442A1 (de) 2024-10-11 2026-04-16 Universität Potsdam, Körperschaft des öffentlichen Rechts Polymer-gekoppelte antikörper und antikörperfragmente

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1382628A1 (en) * 2002-07-16 2004-01-21 Polyganics B.V. Biodegradable phase separated segmented/block co-polyesters

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4429080A (en) 1982-07-01 1984-01-31 American Cyanamid Company Synthetic copolymer surgical articles and method of manufacturing the same
US5066772A (en) 1987-12-17 1991-11-19 Allied-Signal Inc. Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides
US5133739A (en) 1990-02-06 1992-07-28 Ethicon, Inc. Segmented copolymers of ε-caprolactone and glycolide
CN1037612C (zh) * 1992-07-20 1998-03-04 中国科学院化学研究所 热致形状可回复性多嵌段聚合物材料
US5236444A (en) 1992-10-27 1993-08-17 United States Surgical Corporation Absorbable polymers and surgical articles made therefrom
PL174772B1 (pl) * 1993-01-06 1998-09-30 Kinerton Ltd Kompozycja farmaceutyczna zawierająca jonowy konjugat cząsteczkowy
US5403347A (en) 1993-05-27 1995-04-04 United States Surgical Corporation Absorbable block copolymers and surgical articles fabricated therefrom
US5711958A (en) 1996-07-11 1998-01-27 Life Medical Sciences, Inc. Methods for reducing or eliminating post-surgical adhesion formation
US5980948A (en) 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
US6211249B1 (en) 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
WO1999042147A1 (en) 1998-02-23 1999-08-26 Massachusetts Institute Of Technology Biodegradable shape memory polymers
US8158143B2 (en) 2000-07-14 2012-04-17 Helmholtz-Zentrum Geesthacht Zentrum Fuer Material- Und Kuestenforschung Gmbh Systems for releasing active ingredients, based on biodegradable or biocompatible polymers with a shape memory effect
EP1555278A1 (en) * 2004-01-15 2005-07-20 Innocore Technologies B.V. Biodegradable multi-block co-polymers
US20090004243A1 (en) * 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
CA2842514C (en) * 2011-07-22 2018-12-18 Innocore Technologies B.V. Biodegradable, semi-crystalline, phase separated, thermoplastic multi-block copolymers for controlled release of biologically active compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1382628A1 (en) * 2002-07-16 2004-01-21 Polyganics B.V. Biodegradable phase separated segmented/block co-polyesters

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