CL2012001007A1 - Formas cristalinas a-hcl, b-hci y b de n-(4-(7-azabiciclo [2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-dihidroquinolina-3-carboxamida, modulador de cfrt; sus composiciones farmaceuticas; metodo para modular cfrt; y su uso para el tratamiento de la fibrosis quistica, asma, entre otros. - Google Patents

Formas cristalinas a-hcl, b-hci y b de n-(4-(7-azabiciclo [2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-dihidroquinolina-3-carboxamida, modulador de cfrt; sus composiciones farmaceuticas; metodo para modular cfrt; y su uso para el tratamiento de la fibrosis quistica, asma, entre otros.

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Publication number
CL2012001007A1
CL2012001007A1 CL2012001007A CL2012001007A CL2012001007A1 CL 2012001007 A1 CL2012001007 A1 CL 2012001007A1 CL 2012001007 A CL2012001007 A CL 2012001007A CL 2012001007 A CL2012001007 A CL 2012001007A CL 2012001007 A1 CL2012001007 A1 CL 2012001007A1
Authority
CL
Chile
Prior art keywords
cfrt
trifluoromethyl
hcl
dihydroquinoline
heptan
Prior art date
Application number
CL2012001007A
Other languages
English (en)
Spanish (es)
Inventor
Beili Zhang
Mariusz Krawiec
Brian Luisi
Ales Medek
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of CL2012001007A1 publication Critical patent/CL2012001007A1/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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CL2012001007A 2009-10-23 2012-04-20 Formas cristalinas a-hcl, b-hci y b de n-(4-(7-azabiciclo [2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-dihidroquinolina-3-carboxamida, modulador de cfrt; sus composiciones farmaceuticas; metodo para modular cfrt; y su uso para el tratamiento de la fibrosis quistica, asma, entre otros. CL2012001007A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25461409P 2009-10-23 2009-10-23

Publications (1)

Publication Number Publication Date
CL2012001007A1 true CL2012001007A1 (es) 2012-09-07

Family

ID=43334525

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012001007A CL2012001007A1 (es) 2009-10-23 2012-04-20 Formas cristalinas a-hcl, b-hci y b de n-(4-(7-azabiciclo [2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-dihidroquinolina-3-carboxamida, modulador de cfrt; sus composiciones farmaceuticas; metodo para modular cfrt; y su uso para el tratamiento de la fibrosis quistica, asma, entre otros.

Country Status (18)

Country Link
US (2) US8389727B2 (https=)
EP (1) EP2491042A1 (https=)
JP (1) JP5877157B2 (https=)
KR (1) KR20120102645A (https=)
CN (1) CN102666546B (https=)
AR (1) AR078766A1 (https=)
AU (1) AU2010310617A1 (https=)
BR (1) BR112012009584A2 (https=)
CA (1) CA2778493A1 (https=)
CL (1) CL2012001007A1 (https=)
IL (1) IL219327A0 (https=)
MX (1) MX2012004791A (https=)
NZ (1) NZ599703A (https=)
RU (1) RU2568608C2 (https=)
TW (1) TWI507409B (https=)
UA (1) UA108087C2 (https=)
WO (1) WO2011050220A1 (https=)
ZA (1) ZA201202919B (https=)

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RU2006111093A (ru) 2003-09-06 2007-10-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы атр-связывающих кассетных транспортеров
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
RS56037B1 (sr) 2004-06-24 2017-09-29 Vertex Pharma Modulatori atp-vezujućih kasetnih transportera
US7999113B2 (en) 2005-08-11 2011-08-16 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
CN102775396B (zh) 2005-11-08 2014-10-08 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的杂环调控剂
CA2856037C (en) 2005-12-28 2017-03-07 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
EP3219705B1 (en) 2005-12-28 2020-03-11 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of the amorphous form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
EP2674428B1 (en) 2006-04-07 2016-04-06 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
USRE50453E1 (en) 2006-04-07 2025-06-10 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
CN104447716A (zh) 2007-05-09 2015-03-25 沃泰克斯药物股份有限公司 Cftr调节剂
JP5389030B2 (ja) 2007-08-24 2014-01-15 バーテックス ファーマシューティカルズ インコーポレイテッド （特に）嚢胞性線維症の処置に有用なイソチアゾロピリジノン
SI2578571T1 (sl) 2007-11-16 2016-01-29 Vertex Pharmaceuticals Incorporated Izokinolinski modulatorji prenašalcev z atp-vezavno kaseto
EP3683218B1 (en) 2007-12-07 2024-09-18 Vertex Pharmaceuticals Incorporated Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
CN101998854A (zh) * 2007-12-07 2011-03-30 沃泰克斯药物股份有限公司 3-(6-(1-(2,2-二氟苯并[d][1,3]间二氧杂环戊烯-5-基)环丙烷甲酰氨基)-3-甲基吡啶-2-基)苯甲酸的制剂
MX365732B (es) * 2007-12-07 2019-06-12 Vertex Pharma Procesos para producir acidos cicloalquilcarboxamido-piridin benzoicos.
US20100036130A1 (en) 2007-12-07 2010-02-11 Vertex Pharmaceuticals Incorporated Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
NZ720282A (en) 2008-02-28 2017-12-22 Vertex Pharma Heteroaryl derivatives as cftr modulators
NZ616097A (en) 2008-03-31 2015-04-24 Vertex Pharma Pyridyl derivatives as cftr modulators
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
AR073709A1 (es) 2008-09-29 2010-11-24 Vertex Pharma Unidades de dosis de acido 3-(6-(1-(2,2-difluorobenzeno (d) (1,3) dioxol-5-il) ciclopropancarboxamido)-3-metilpiridin-2-il) benzoico
CN102224141B (zh) * 2008-10-23 2014-10-08 沃泰克斯药物股份有限公司 N-(4-(7-氮杂双环[2.2.1]庚-7-基)-2-(三氟甲基)苯基)-4-氧代-5-(三氟甲基)-1,4-二氢喹啉-3-甲酰胺的固体形式
EP2349263B1 (en) * 2008-10-23 2014-04-23 Vertex Pharmaceuticals Inc. Modulators of cystic fibrosis transmembrane conductance regulator
PL2408750T3 (pl) 2009-03-20 2016-02-29 Vertex Pharma Sposób otrzymywania modulatorów błonowego regulatora przewodnictwa swoistego dla mukowiscydozy
BR112012006031A2 (pt) * 2009-09-17 2019-09-24 Vertex Pharma processo para preparação de compostos azabicíclicos.
US8344147B2 (en) * 2009-10-23 2013-01-01 Vertex Pharmaceutical Incorporated Process for preparing modulators of cystic fibrosis transmembrane conductance regulator
CN102666546B (zh) * 2009-10-23 2015-09-09 沃泰克斯药物股份有限公司 N-(4-(7-氮杂双环[2.2.1]庚-7-基)-2-(三氟甲基)苯基)-4-氧代-5-(三氟甲基)-1,4-二氢喹啉-3-甲酰胺的固体形式
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
MX2012011655A (es) 2010-04-07 2012-11-23 Vertex Pharma Formas solidas de acido 3-(6-(1-(2,2-difluorobenzo [d][1-3]dioxol-5-il]ciclopropanocarboxamido)-3-metilpiridin-2-il) benzoico.
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