CL2009000723A1 - Metodo de purificacion industrial de ficotoxinas biologicamente activas que comprende proporcionar una cantidad adecuada de una fuente de ficotoxinas como por ejemplo el cultivo de un clon de cianobacterias. - Google Patents

Metodo de purificacion industrial de ficotoxinas biologicamente activas que comprende proporcionar una cantidad adecuada de una fuente de ficotoxinas como por ejemplo el cultivo de un clon de cianobacterias.

Info

Publication number
CL2009000723A1
CL2009000723A1 CL2009000723A CL2009000723A CL2009000723A1 CL 2009000723 A1 CL2009000723 A1 CL 2009000723A1 CL 2009000723 A CL2009000723 A CL 2009000723A CL 2009000723 A CL2009000723 A CL 2009000723A CL 2009000723 A1 CL2009000723 A1 CL 2009000723A1
Authority
CL
Chile
Prior art keywords
phycotoxins
cyanobacterial
clone
cultivation
source
Prior art date
Application number
CL2009000723A
Other languages
English (en)
Inventor
Gonzalez Marcelo Santiago Lagos
Original Assignee
Proteus Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteus Sa filed Critical Proteus Sa
Priority to CL2009000723A priority Critical patent/CL2009000723A1/es
Publication of CL2009000723A1 publication Critical patent/CL2009000723A1/es
Priority to ES10755518.7T priority patent/ES2562637T3/es
Priority to CA2754154A priority patent/CA2754154C/en
Priority to HUE10755518A priority patent/HUE027480T2/en
Priority to JP2012501444A priority patent/JP5728774B2/ja
Priority to MX2011010005A priority patent/MX2011010005A/es
Priority to PE2011001285A priority patent/PE20110903A1/es
Priority to DK10755518.7T priority patent/DK2412714T5/en
Priority to PCT/IB2010/051187 priority patent/WO2010109386A1/es
Priority to BRPI1013548A priority patent/BRPI1013548B8/pt
Priority to EP10755518.7A priority patent/EP2412714B9/en
Priority to KR1020117021288A priority patent/KR20110130420A/ko
Priority to ARP100100934A priority patent/AR075931A1/es
Priority to US13/243,119 priority patent/US8957207B2/en
Priority to US13/243,153 priority patent/US8952152B2/en
Priority to US14/570,360 priority patent/US9249150B2/en
Priority to US14/570,373 priority patent/US20150099879A1/en
Priority to HRP20160079TT priority patent/HRP20160079T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Método de purificación industrial de ficotoxinas biológicamente activas que comprende proporcionar una cantidad adecuada de una fuente de ficotoxinas como por ejemplo el cultivo de un clon de cianobacterias.
CL2009000723A 2009-03-24 2009-03-24 Metodo de purificacion industrial de ficotoxinas biologicamente activas que comprende proporcionar una cantidad adecuada de una fuente de ficotoxinas como por ejemplo el cultivo de un clon de cianobacterias. CL2009000723A1 (es)

Priority Applications (18)

Application Number Priority Date Filing Date Title
CL2009000723A CL2009000723A1 (es) 2009-03-24 2009-03-24 Metodo de purificacion industrial de ficotoxinas biologicamente activas que comprende proporcionar una cantidad adecuada de una fuente de ficotoxinas como por ejemplo el cultivo de un clon de cianobacterias.
KR1020117021288A KR20110130420A (ko) 2009-03-24 2010-03-18 생물학적 활성 조류독소의 산업적 정제 방법
PCT/IB2010/051187 WO2010109386A1 (es) 2009-03-24 2010-03-18 Método de purificación industrial de ficotoxinas biológicamente activas
EP10755518.7A EP2412714B9 (en) 2009-03-24 2010-03-18 Method for the industrial purification of biologically active phycotoxins
HUE10755518A HUE027480T2 (en) 2009-03-24 2010-03-18 A method for the purification of biologically active phytoxins in industry
JP2012501444A JP5728774B2 (ja) 2009-03-24 2010-03-18 生物学的に活性な藻類毒素の工業的精製法
MX2011010005A MX2011010005A (es) 2009-03-24 2010-03-18 Metodo de purificacion industrial de ficotoxinas biologicamente activas.
PE2011001285A PE20110903A1 (es) 2009-03-24 2010-03-18 Metodo de purificacion industrial de ficotoxinas biologicamente activas
DK10755518.7T DK2412714T5 (en) 2009-03-24 2010-03-18 Process for Industrial Purification of Biologically Active Phycotoxins
ES10755518.7T ES2562637T3 (es) 2009-03-24 2010-03-18 Método para la purificación industrial de ficotoxinas biológicamente activas
BRPI1013548A BRPI1013548B8 (pt) 2009-03-24 2010-03-18 método de purificação industrial de ficotoxinas biologicamente ativas
CA2754154A CA2754154C (en) 2009-03-24 2010-03-18 Method for the industrial purification of biologically active phycotoxins
ARP100100934A AR075931A1 (es) 2009-03-24 2010-03-23 Metodo de purificacion industrial de ficotoxinas biologicamente activas
US13/243,119 US8957207B2 (en) 2009-03-24 2011-09-23 Methods for producing phycotoxins
US13/243,153 US8952152B2 (en) 2009-03-24 2011-09-23 Methods for purifying phycotoxins, pharmaceutical compositions containing purified phycotoxins, and methods of use thereof
US14/570,360 US9249150B2 (en) 2009-03-24 2014-12-15 Methods for purifying phycotoxins, pharmaceutical compositions containing purified phycotoxins, and methods of use thereof
US14/570,373 US20150099879A1 (en) 2009-03-24 2014-12-15 Methods for producing phycotoxins
HRP20160079TT HRP20160079T1 (hr) 2009-03-24 2016-01-25 Postupak industrijskog pročišćavanja biološki aktivnih fikotoksina

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CL2009000723A CL2009000723A1 (es) 2009-03-24 2009-03-24 Metodo de purificacion industrial de ficotoxinas biologicamente activas que comprende proporcionar una cantidad adecuada de una fuente de ficotoxinas como por ejemplo el cultivo de un clon de cianobacterias.

Publications (1)

Publication Number Publication Date
CL2009000723A1 true CL2009000723A1 (es) 2009-06-19

Family

ID=42780210

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009000723A CL2009000723A1 (es) 2009-03-24 2009-03-24 Metodo de purificacion industrial de ficotoxinas biologicamente activas que comprende proporcionar una cantidad adecuada de una fuente de ficotoxinas como por ejemplo el cultivo de un clon de cianobacterias.

Country Status (14)

Country Link
EP (1) EP2412714B9 (es)
JP (1) JP5728774B2 (es)
KR (1) KR20110130420A (es)
AR (1) AR075931A1 (es)
BR (1) BRPI1013548B8 (es)
CA (1) CA2754154C (es)
CL (1) CL2009000723A1 (es)
DK (1) DK2412714T5 (es)
ES (1) ES2562637T3 (es)
HR (1) HRP20160079T1 (es)
HU (1) HUE027480T2 (es)
MX (1) MX2011010005A (es)
PE (1) PE20110903A1 (es)
WO (1) WO2010109386A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8957207B2 (en) 2009-03-24 2015-02-17 Proteus S.A. Methods for producing phycotoxins
EP2968225B1 (en) 2013-03-15 2019-02-20 The Children's Medical Center Corporation Neosaxitoxin combination formulations for prolonged local anesthesia
US9902625B2 (en) 2014-09-03 2018-02-27 International Business Machines Corporation Removal of HAB-produced toxins from bodies of water
GB201602576D0 (en) 2016-02-12 2016-03-30 Bergen Teknologioverforing As Process
CN107602580B (zh) * 2017-09-08 2019-06-11 浙江理工大学 一种聚酮类化合物及其制备方法和应用
CN109142595A (zh) * 2018-08-23 2019-01-04 中国水产科学研究院黄海水产研究所 一种麻痹性贝类毒素标准溶液的制备方法
CA3113727A1 (en) * 2018-09-21 2020-03-26 The Cawthron Institute Trust Board A semisynthetic method of preparing neosaxitoxin
EP3853231A4 (en) * 2018-09-21 2022-05-11 The Cawthron Institute Trust Board PREPARATIVE SCALE CONVERSION OF GONYAUTOXINS TO NEOSAXITOXIN
CN114657222A (zh) * 2022-04-08 2022-06-24 湖北省水利水电科学研究院 一种从水华束丝藻中提取类菌胞素氨基酸的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001413A (en) 1973-06-12 1977-01-04 Astra Pharmaceutical Products, Inc. Pharmaceutical local anesthetic composition employing saxitoxin
US6030974A (en) * 1997-04-02 2000-02-29 The Regents Of The University Of California Method of anesthesia
ES2401570T3 (es) * 2001-11-15 2013-04-22 Phytotox Limited Composiciones farmacéuticas que contienen 3,4-propinoperhidropurinas y usos de las mismas para bloquear la transmisión neuronal
CA2607589A1 (en) * 2004-05-07 2005-11-24 Phytotox Limited Methods of treating wounds with gonyautoxins
DE102006028817A1 (de) * 2006-06-21 2007-12-27 Evonik Degussa Gmbh Aufarbeitung von Reaktionslösungen aus Ganzzell-Biotransformationen

Also Published As

Publication number Publication date
BRPI1013548B8 (pt) 2021-05-25
ES2562637T9 (es) 2017-05-30
HRP20160079T1 (hr) 2016-04-08
CA2754154C (en) 2013-12-17
EP2412714B9 (en) 2016-11-23
EP2412714A1 (en) 2012-02-01
DK2412714T3 (en) 2016-02-01
MX2011010005A (es) 2011-10-10
JP2012521408A (ja) 2012-09-13
JP5728774B2 (ja) 2015-06-03
PE20110903A1 (es) 2012-01-19
HUE027480T2 (en) 2016-09-28
EP2412714A4 (en) 2012-10-10
DK2412714T5 (en) 2017-02-27
BRPI1013548A2 (pt) 2016-09-20
ES2562637T3 (es) 2016-03-07
WO2010109386A1 (es) 2010-09-30
KR20110130420A (ko) 2011-12-05
BRPI1013548B1 (pt) 2020-06-09
CA2754154A1 (en) 2010-09-30
EP2412714B1 (en) 2015-11-11
AR075931A1 (es) 2011-05-04

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