CL2008003091A1 - Forma cristalina 1 de etanolato de n-(4-(3-amino-1h-indazol-4il)fenil)-n-(2-fluoro-5-metilfenil)urea. 1/4; composicion farmaceutica; y uso en el tratamiento de cancer en un mamifero. - Google Patents
Forma cristalina 1 de etanolato de n-(4-(3-amino-1h-indazol-4il)fenil)-n-(2-fluoro-5-metilfenil)urea. 1/4; composicion farmaceutica; y uso en el tratamiento de cancer en un mamifero.Info
- Publication number
- CL2008003091A1 CL2008003091A1 CL2008003091A CL2008003091A CL2008003091A1 CL 2008003091 A1 CL2008003091 A1 CL 2008003091A1 CL 2008003091 A CL2008003091 A CL 2008003091A CL 2008003091 A CL2008003091 A CL 2008003091A CL 2008003091 A1 CL2008003091 A1 CL 2008003091A1
- Authority
- CL
- Chile
- Prior art keywords
- indazol
- methylphenyl
- mammal
- fluoro
- phenyl
- Prior art date
Links
- 241000124008 Mammalia Species 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 4- (3-amino-1h-indazol-4-yl) phenyl Chemical group 0.000 title 1
- MPVGZUGXCQEXTM-UHFFFAOYSA-N linifanib Chemical compound CC1=CC=C(F)C(NC(=O)NC=2C=CC(=CC=2)C=2C=3C(N)=NNC=3C=CC=2)=C1 MPVGZUGXCQEXTM-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Forma cristalina 1 de n-(4-(3-amino-1h-indazol-4-il)fenil)-n’-(2-fluoro-5-metilfenil)urea hidrato, procedimiento de preparación, composición farmacéutica, útil para el tratamiento del cáncer en un mamífero.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98131007P | 2007-10-19 | 2007-10-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2008003091A1 true CL2008003091A1 (es) | 2009-09-04 |
Family
ID=40174825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2008003091A CL2008003091A1 (es) | 2007-10-19 | 2008-10-17 | Forma cristalina 1 de etanolato de n-(4-(3-amino-1h-indazol-4il)fenil)-n-(2-fluoro-5-metilfenil)urea. 1/4; composicion farmaceutica; y uso en el tratamiento de cancer en un mamifero. |
Country Status (25)
Country | Link |
---|---|
US (1) | US7994208B2 (es) |
EP (1) | EP2195300B1 (es) |
JP (2) | JP5878689B2 (es) |
KR (1) | KR20100085986A (es) |
CN (1) | CN101827821B (es) |
AR (1) | AR068918A1 (es) |
AU (1) | AU2008312528A1 (es) |
BR (1) | BRPI0818067A2 (es) |
CA (1) | CA2699302C (es) |
CL (1) | CL2008003091A1 (es) |
CO (1) | CO6280482A2 (es) |
CR (1) | CR11387A (es) |
DO (1) | DOP2010000113A (es) |
EC (1) | ECSP10010182A (es) |
ES (1) | ES2547878T3 (es) |
GT (1) | GT201000093A (es) |
MX (1) | MX2010004288A (es) |
PA (1) | PA8800301A1 (es) |
PE (1) | PE20091075A1 (es) |
RU (1) | RU2010119927A (es) |
TW (1) | TW200932728A (es) |
UA (1) | UA99747C2 (es) |
UY (1) | UY31408A1 (es) |
WO (1) | WO2009052225A1 (es) |
ZA (1) | ZA201002180B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7994208B2 (en) * | 2007-10-19 | 2011-08-09 | Abbott Laboratories | Crystalline chemotherapeutic |
US20140212355A1 (en) * | 2013-01-28 | 2014-07-31 | Abbott Cardiovascular Systems Inc. | Trans-arterial drug delivery |
JP7346916B2 (ja) * | 2019-06-04 | 2023-09-20 | 京セラドキュメントソリューションズ株式会社 | 緩衝構造体およびそれを備えた包装材 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7297709B2 (en) * | 2003-05-22 | 2007-11-20 | Abbott Laboratories | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors |
CN1826324B (zh) | 2003-05-22 | 2011-12-07 | 雅培制药有限公司 | 吲唑、苯并异*唑和苯并异噻唑激酶抑制剂 |
WO2007015569A1 (ja) * | 2005-08-01 | 2007-02-08 | Eisai R & D Management Co., Ltd. | 血管新生阻害物質の効果を予測する方法 |
WO2007015578A1 (ja) * | 2005-08-02 | 2007-02-08 | Eisai R & D Management Co., Ltd. | 血管新生阻害物質の効果を検定する方法 |
WO2007050574A1 (en) | 2005-10-25 | 2007-05-03 | Abbott Laboratories | Formulation comprising a drug of low water solubility and method of use thereof |
WO2007076358A1 (en) * | 2005-12-23 | 2007-07-05 | Alcon, Inc. | PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE |
JP2010509289A (ja) * | 2006-11-09 | 2010-03-25 | アボット ゲーエムベーハー ウント コンパニー カーゲー | チロシンキナーゼ阻害剤の経口投与用薬学的剤形 |
US7994208B2 (en) * | 2007-10-19 | 2011-08-09 | Abbott Laboratories | Crystalline chemotherapeutic |
-
2008
- 2008-10-15 US US12/251,949 patent/US7994208B2/en not_active Expired - Fee Related
- 2008-10-16 UA UAA201006034A patent/UA99747C2/ru unknown
- 2008-10-16 BR BRPI0818067 patent/BRPI0818067A2/pt not_active IP Right Cessation
- 2008-10-16 MX MX2010004288A patent/MX2010004288A/es active IP Right Grant
- 2008-10-16 ES ES08840138.5T patent/ES2547878T3/es active Active
- 2008-10-16 CN CN200880111903XA patent/CN101827821B/zh not_active Expired - Fee Related
- 2008-10-16 CA CA2699302A patent/CA2699302C/en not_active Expired - Fee Related
- 2008-10-16 JP JP2010530089A patent/JP5878689B2/ja not_active Expired - Fee Related
- 2008-10-16 WO PCT/US2008/080060 patent/WO2009052225A1/en active Application Filing
- 2008-10-16 RU RU2010119927/04A patent/RU2010119927A/ru not_active Application Discontinuation
- 2008-10-16 KR KR1020107010989A patent/KR20100085986A/ko not_active Application Discontinuation
- 2008-10-16 AU AU2008312528A patent/AU2008312528A1/en not_active Abandoned
- 2008-10-16 EP EP08840138.5A patent/EP2195300B1/en active Active
- 2008-10-17 CL CL2008003091A patent/CL2008003091A1/es unknown
- 2008-10-17 UY UY31408A patent/UY31408A1/es not_active Application Discontinuation
- 2008-10-17 PA PA20088800301A patent/PA8800301A1/es unknown
- 2008-10-17 AR ARP080104544A patent/AR068918A1/es not_active Application Discontinuation
- 2008-10-17 PE PE2008001782A patent/PE20091075A1/es not_active Application Discontinuation
- 2008-10-17 TW TW097140031A patent/TW200932728A/zh unknown
-
2010
- 2010-03-26 ZA ZA2010/02180A patent/ZA201002180B/en unknown
- 2010-04-14 GT GT201000093A patent/GT201000093A/es unknown
- 2010-04-16 DO DO2010000113A patent/DOP2010000113A/es unknown
- 2010-04-23 CR CR11387A patent/CR11387A/es not_active Application Discontinuation
- 2010-04-27 CO CO10049263A patent/CO6280482A2/es not_active Application Discontinuation
- 2010-05-17 EC EC2010010182A patent/ECSP10010182A/es unknown
-
2014
- 2014-09-29 JP JP2014198628A patent/JP2015042650A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CO6280482A2 (es) | 2011-05-20 |
JP5878689B2 (ja) | 2016-03-08 |
EP2195300B1 (en) | 2015-06-24 |
UY31408A1 (es) | 2009-05-29 |
ES2547878T3 (es) | 2015-10-09 |
MX2010004288A (es) | 2010-04-30 |
DOP2010000113A (es) | 2010-07-31 |
JP2015042650A (ja) | 2015-03-05 |
CR11387A (es) | 2010-08-18 |
GT201000093A (es) | 2012-03-12 |
KR20100085986A (ko) | 2010-07-29 |
US7994208B2 (en) | 2011-08-09 |
CA2699302C (en) | 2016-06-21 |
ECSP10010182A (es) | 2010-06-29 |
US20090105326A1 (en) | 2009-04-23 |
CN101827821B (zh) | 2012-09-05 |
RU2010119927A (ru) | 2011-11-27 |
PA8800301A1 (es) | 2009-08-26 |
UA99747C2 (en) | 2012-09-25 |
CA2699302A1 (en) | 2009-04-23 |
EP2195300A1 (en) | 2010-06-16 |
ZA201002180B (en) | 2011-10-26 |
WO2009052225A1 (en) | 2009-04-23 |
JP2011500704A (ja) | 2011-01-06 |
PE20091075A1 (es) | 2009-08-27 |
TW200932728A (en) | 2009-08-01 |
CN101827821A (zh) | 2010-09-08 |
AU2008312528A1 (en) | 2009-04-23 |
AR068918A1 (es) | 2009-12-16 |
BRPI0818067A2 (pt) | 2015-03-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ECSP10010361A (es) | Derivados de piridazinona | |
CR8642A (es) | Compuestos, composiciones farmaceuticas y metodos para su uso en el tratameinto de desordenes metabolicos | |
BRPI0813237A2 (pt) | Composto, método para preparar o composto, composição, medicamento, e, uso do composto. | |
CL2011002442A1 (es) | Un compuesto n-(4-(4-(3-(3-terc-butil-1-p-tolil-1h-pirazol-5-il)ureido)naftalen-1-iloxi)piridin-2-il)-2-metoxiacetamida o una sal, estereoisomeros y tautomeros del mismo; composicion farmaceutica; y su uso para tratar o prevenir una afeccion seleccionada de epoc, asma e inhibicion del crecimiento y metastasis de tumores, entre otras. | |
GT201200333A (es) | Dispersiones sòlidas que contienen inhibidores de quinasas | |
AR053169A1 (es) | Metabolitos de n-2 (cloro-6-metilfenil)-2-[[6-[4-(2-hidroxietil)-1-piperazinil) -2-metil -4-pi rimidinil] amino]-5-tiazol carboxamidas | |
CL2008002247A1 (es) | Compuestos derivados de fenil amida; proceso de preparacion; composicion farmaceutica que los contiene; y su uso en la preparacion de medicamentos para el tratamiento de trastornos del sueno, narcolepsia y trastornos psiquiatricos, entre otros. | |
SI2201018T1 (sl) | Trdne oblike, ki obsegajo N-(5-terc.butil-izoksazol-3-il)-N'-(4-Y7-(2- morfolin-4-il-etoksi)imidazoY2,1-B"Y 1,3"benzotiazol-2-ilfenil)sečnina, njihove sestave in uporabe z njimi | |
BRPI0513944A (pt) | forma substancialmente pura de um composto de quinazolina, uso de um composto de quinazolina e composição | |
CL2010001362A1 (es) | Forma de dosificacion farmaceutica para la liberacion inmediata de la sustancia activa 3-z-[1-(4-(n-((4-metil-piperazin-1-il)-metilcarbonil)-n-metil-amino)-anilino)-1-fenil-metileno]-6-metoxicarbonil-2-indolinona-monoetanosulfonato; y su uso para el tratamiento y/o prevencion de enfermedades oncologicas e inmunologicas, entre otras. | |
CL2007000680A1 (es) | Compuesto cristalino (5s)-5-[4(cloro-piridin-2-iloxi)-piperidin-1-sulfonilmetil]-5-metil-imidazolidin-2,4-diona, forma g; proceso de preparacion; composicion farmaceutica; y uso para el tratamiento de epoc. | |
MX2012014386A (es) | Formas cristalinas de inhibidores de cinasa. | |
CL2008003091A1 (es) | Forma cristalina 1 de etanolato de n-(4-(3-amino-1h-indazol-4il)fenil)-n-(2-fluoro-5-metilfenil)urea. 1/4; composicion farmaceutica; y uso en el tratamiento de cancer en un mamifero. | |
CR20110082A (es) | Nuevos inhibidores de la proteina tirosina quinasa y receptores vegf-2 y uso farmacéutico de los mismos | |
BRPI0821116B8 (pt) | composto, composição farmacêutica que o contem, uso deste e processo para a preparação do mesmo | |
EA200801875A1 (ru) | Антагонист cd 80 | |
CR11386A (es) | Productos quimioterapeuticos cristalinos | |
GT201000100A (es) | Productos quimioterapéuticos cristalinos | |
ECSP10010175A (es) | Productos quimioterapéuticos cristalinos | |
AR052015A1 (es) | Agente para la profilaxis o tratamiento del sindrome metabolico | |
BRPI0912038A2 (pt) | composto, mistura, composição farmacêutica, uso do composto, e, métodos para tratar e evitar uma infecção por picornavírus, e para formar o composto | |
EP1900735A4 (en) | PYRIDAZINYLAMINE DERIVATIVES, USE OF DERIVATIVES IN THE PREPARATION OF PICORNAVIRUS INHIBITORS | |
BRPI0818065A8 (pt) | Quimioterapêutco derivado de indazol cristalino | |
CL2009001494A1 (es) | Compuestos derivados de n-((5s)-3-(4-(3-pirrolidin-1-il)fenil)-2-oxo-5-oxazolidinmetil)acetamida; procedimiento para prepararlos; composicion farmaceutica; y su uso para el tratamiento de infecciones bacterianas. | |
CL2014001548A1 (es) | Composicion que comprende n-(4-{4-amino-7-[1-(2-hidroxietil)-1h-pirazol-4-il]tieno[3,2-c]priridin-3-il}fenil)-n'-(3-fluorofenil)urea o una sal, b) polietilenglicol, c) aceite de ricino polioxietilado y d) etanol; y su uso para tratar el cancer. |