CH90807A - Process for the preparation of a derivative of nicotinic acid. - Google Patents

Process for the preparation of a derivative of nicotinic acid.

Info

Publication number
CH90807A
CH90807A CH90807DA CH90807A CH 90807 A CH90807 A CH 90807A CH 90807D A CH90807D A CH 90807DA CH 90807 A CH90807 A CH 90807A
Authority
CH
Switzerland
Prior art keywords
nicotinic acid
derivative
preparation
diethylamine
water
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH90807A publication Critical patent/CH90807A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Description

       

  Verfahren zur Herstellung eines Derivates der Nikotinsäure.    Es wurde gefunden,     dass-    man zu einem  Derivat der Nikotinsäure gelangen kann,  wenn man Verbindungen" welche den     Ni-          kotinsä.Lirerest    enthalten, z. B. Nikotinsäure  halogenide, mit     Diäthylamin    behandelt.  



  Das so entstehende     Nikotinsäurediäthyl-          a,mid    stellt ein gelbliches 01 vom Siedepunkt  <B>280' (175'</B> bei 25 mm Druck) dar, welches  in Wasser und organischen Lösungsmitteln  leicht löslich ist und     aits'    der wässerigen Lö  sung durch konzentrierte     Alkalilauge    ausge  schieden wird.  



  Die neue Verbindung besitzt wertvolle  therapeutische Eigenschaften.  



       Beispiel:          Nikotinsäurechlorid    wird mit der     äqui-          v        aleiiten    Menge     Diätliylaminchlorhydrat    zwei       Stunden    im     O1bad    auf<B>160'</B> erhitzt. Es er  folgt lebhafte     Entwicklung    von Salzsäure  dämpfen. Die Schmelze wird in Wasser ge  löst, mit     Kaliumhydroxydlösung    1; 1 ver  setzt und mit Äther ausgeschüttelt.

   Die    Ätherlösung wird über     Atzkali.    getrocknet  und der Äther -     abdestilliert.    Das zurück  bleibende rohe     Nikotiusäurediäthylamid        wird          dilrch    Destillation im Vakuum gereinigt.



  Process for the preparation of a derivative of nicotinic acid. It has been found that a derivative of nicotinic acid can be obtained if compounds which contain the nicotinic acid residue, for example nicotinic acid halides, are treated with diethylamine.



  The resulting nicotinic acid diethyl amide is a yellowish oil with a boiling point of <B> 280 '(175' </B> at 25 mm pressure), which is easily soluble in water and organic solvents and passes through the aqueous solution concentrated alkali lye is excreted.



  The new compound has valuable therapeutic properties.



       Example: Nicotinic acid chloride is heated to <B> 160 '</B> in an O1 bath for two hours with the equivalent amount of diethylamine chlorohydrate. It follows lively development of hydrochloric acid steam. The melt is dissolved in water, with potassium hydroxide solution 1; 1 relocated and shaken out with ether.

   The ethereal solution is via Atzkali. dried and the ether - distilled off. The remaining crude Nicotius acid diethylamide is purified by distillation in vacuo.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines -Deriva tes der Nikotinsäure, dadurch- gekennzeichnet, dass man Verbindungen, welche den Nikotin säurerest enthalten, mit Diäthylamin behau- Belt. Das so entstehende Nikotinsäurediäthyl- amid stellt ein gelbliches 01 vom Siedepunkt- 280' <B>(175'</B> bei 25 mm Druck) dar, welches in Wasser und organischen. PATENT CLAIM: Process for the preparation of a derivative of nicotinic acid, characterized in that compounds which contain the nicotine acid residue are treated with diethylamine. The resulting nicotinic acid diethylamide is a yellowish oil with a boiling point of 280 '(175' at 25 mm pressure), which in water and organic. Lösungsmitteln leicht löslich ist und aus der wässerigen Lö sung durch konzentrierte Alkalilauge aus geschieden wird. Die neue Verbindung besitzt wertvolle therapeutische Eigenschaften. Solvents is easily soluble and is separated from the aqueous solution by concentrated alkali lye. The new compound has valuable therapeutic properties.
CH90807D 1920-07-21 1920-07-21 Process for the preparation of a derivative of nicotinic acid. CH90807A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH90807T 1920-07-21

Publications (1)

Publication Number Publication Date
CH90807A true CH90807A (en) 1921-09-16

Family

ID=4348128

Family Applications (1)

Application Number Title Priority Date Filing Date
CH90807D CH90807A (en) 1920-07-21 1920-07-21 Process for the preparation of a derivative of nicotinic acid.

Country Status (1)

Country Link
CH (1) CH90807A (en)

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