CH91105A - Process for the preparation of a derivative of nicotinic acid. - Google Patents

Process for the preparation of a derivative of nicotinic acid.

Info

Publication number
CH91105A
CH91105A CH91105DA CH91105A CH 91105 A CH91105 A CH 91105A CH 91105D A CH91105D A CH 91105DA CH 91105 A CH91105 A CH 91105A
Authority
CH
Switzerland
Prior art keywords
nicotinic acid
derivative
preparation
piperidine
water
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH91105A publication Critical patent/CH91105A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

      Verfahren    zur Herstellung eines     Derivates    der     Nikotinsäure.       Es wurde gefunden, dass man zu einem  Derivat der Nikotinsäure gelangen kann,  wenn man Verbindungen, welche den Nikotin  säurerest enthalten, wie z. B.     Nikotinsäure-          halogenide,    mit     Piperidin    behandelt.  



  Das so entstehende     Nikotinsäurepiper-idid     bildet ein     dickes,    bei 310   siedendes Öl, wel  ches in Wasser und organischen Lösungs  mitteln leicht löslich ist.  



  Die neue Verbindung besitzt wertvolle  therapeutische Eigenschaften.  



       Beispiel:          Nikotinsäurebromid    wird mit der äqui  valenten Menge     Piperidinbromhydrat        irn        O1-          bad    während mehreren Stunden auf zirka  <B>1601</B> erhitzt. Nach Beendigung der Brom  wasserstoff-Entwicklung wird die Schmelze    in Wasser gelöst, mit     Kalitunhydroxydlösung     1 : 1 versetzt und mit Äther     abdestilliert.    Das  zurückbleibende rohe     Nikotinsäurepiperidid     wird durch Destillation gereinigt.



      Process for the preparation of a derivative of nicotinic acid. It has been found that a derivative of nicotinic acid can be obtained if compounds which contain the nicotine acid residue, such as. B. nicotinic acid halides, treated with piperidine.



  The resulting nicotinic acid piperidide forms a thick oil boiling at 310 ° C, which is easily soluble in water and organic solvents.



  The new compound has valuable therapeutic properties.



       Example: Nicotinic acid bromide is heated with the equivalent amount of piperidine bromohydrate in an O1 bath for several hours to around <B> 1601 </B>. After the evolution of hydrogen bromide has ended, the melt is dissolved in water, 1: 1 potassium hydroxide solution is added and the mixture is distilled off with ether. The remaining crude nicotinic acid piperidide is purified by distillation.

Claims (1)

PAT EN T ANSPRUCH Verfahren zur Darstellung eines Derivates der Nikotinsäure, dadurch gekennzeichnet, daf.) man Verbindungen, welche den Nikotinsä.ure- rest enthalten, mit Piperidin behandelt. Das so entstehende Nikotinsäurepiperidid bildet ein dickes, bei<B>3101</B> siedendes<B>01,</B> wel ches in Wasser und organischen Lüsungs- rnitteln leicht löslich ist. A method for the preparation of a derivative of nicotinic acid, characterized in that compounds which contain the nicotinic acid residue are treated with piperidine. The resulting nicotinic acid piperidide forms a thick <B> 01 </B> boiling at <B> 3101 </B>, which is easily soluble in water and organic solvents. Die neue Verbindung besitzt wertvolle therapeutische Eigenschaften. The new compound has valuable therapeutic properties.
CH91105D 1920-07-21 1920-07-21 Process for the preparation of a derivative of nicotinic acid. CH91105A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH90807T 1920-07-21
CH91105T 1920-07-21

Publications (1)

Publication Number Publication Date
CH91105A true CH91105A (en) 1921-10-01

Family

ID=25704245

Family Applications (1)

Application Number Title Priority Date Filing Date
CH91105D CH91105A (en) 1920-07-21 1920-07-21 Process for the preparation of a derivative of nicotinic acid.

Country Status (1)

Country Link
CH (1) CH91105A (en)

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