CH91104A - Process for the preparation of a derivative of nicotinic acid. - Google Patents

Process for the preparation of a derivative of nicotinic acid.

Info

Publication number
CH91104A
CH91104A CH91104DA CH91104A CH 91104 A CH91104 A CH 91104A CH 91104D A CH91104D A CH 91104DA CH 91104 A CH91104 A CH 91104A
Authority
CH
Switzerland
Prior art keywords
nicotinic acid
derivative
preparation
soluble
diamylamine
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH91104A publication Critical patent/CH91104A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung eines Derivates der Nikotinsäure.    Es wurde gefunden, dass man zu einem  Derivat der Nikotinsäure gelangen kann, wein  man     Verbindungen,    welche den Nikotinsäure  rest enthalten, wie z. B.     Nikotinsäurehaloge-          nide,    mit     Diamylamin    behandelt.  



  Das so entstehende     Nikotinsäurediamil-          amid    stellt ein gelbliches<B>01</B> vom Siedepunkt  2100/20 mm dar, welches in Äther löslich,  in Wasser wenig löslich ist.  



  Die neue Verbindung besitzt wertvolle  therapeutische Eigenschaften.  



  <I>Beispiel:</I>       21g        Nikotinsäurechlorid    werden mit 28 g       Diamylchlorhydrat    gut gemischt und auf 180    erhitzt. Nach dein     Alkalischmachen    und Aus-         äthern    wird das     Nikotinsiiur-ediamylamid        durch          Fraktionieren        als    gelbliebes Öl erhalten.



  Process for the preparation of a derivative of nicotinic acid. It has been found that a derivative of nicotinic acid can be obtained by using compounds which contain the nicotinic acid residue, such as. B. Nicotinic acid halides, treated with diamylamine.



  The nicotinic acid diamilamide produced in this way is a yellowish <B> 01 </B> with a boiling point of 2100/20 mm, which is soluble in ether and sparingly soluble in water.



  The new compound has valuable therapeutic properties.



  <I> Example: </I> 21 g nicotinic acid chloride are mixed well with 28 g diamyl chlorohydrate and heated to 180. After making it alkaline and etherifying it, the nicotinic acid ediamylamide is obtained as a yellow-sweet oil by fractionation.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines Derivates der Nihotinsüure, dadurch gekennzeichnet, dass man Verbindungen, welche den Nikotins.i,ure- rest enthalten, mit Diamylamin behandelt. Das so entstehende Nikotinsäurediamyl- amid stellt ein gelbliches<B>61</B> vom Siedepunkt 210'/20 mm dar, welches in Äther löslich, in Wasser weniger löslich ist. Die neue Verbindung besitzt wertvolle therapeutische Eigenschaften. PATENT CLAIM: Process for the preparation of a derivative of nihotinic acid, characterized in that compounds containing the nicotinic acid residue are treated with diamylamine. The nicotinic acid diamylamide produced in this way is a yellowish <B> 61 </B> with a boiling point of 210 '/ 20 mm, which is soluble in ether and less soluble in water. The new compound has valuable therapeutic properties.
CH91104D 1920-07-21 1920-07-21 Process for the preparation of a derivative of nicotinic acid. CH91104A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH90807T 1920-07-21
CH91104T 1920-07-21

Publications (1)

Publication Number Publication Date
CH91104A true CH91104A (en) 1921-10-01

Family

ID=25704244

Family Applications (1)

Application Number Title Priority Date Filing Date
CH91104D CH91104A (en) 1920-07-21 1920-07-21 Process for the preparation of a derivative of nicotinic acid.

Country Status (1)

Country Link
CH (1) CH91104A (en)

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