CH700138B1 - Matrice per impianto osseo e procedimento di preparazione della stessa. - Google Patents
Matrice per impianto osseo e procedimento di preparazione della stessa. Download PDFInfo
- Publication number
- CH700138B1 CH700138B1 CH01997/08A CH19972008A CH700138B1 CH 700138 B1 CH700138 B1 CH 700138B1 CH 01997/08 A CH01997/08 A CH 01997/08A CH 19972008 A CH19972008 A CH 19972008A CH 700138 B1 CH700138 B1 CH 700138B1
- Authority
- CH
- Switzerland
- Prior art keywords
- matrix
- bone
- bone implant
- poly
- implant according
- Prior art date
Links
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 101
- 239000011159 matrix material Substances 0.000 title claims abstract description 79
- 239000007943 implant Substances 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title abstract description 18
- 238000002360 preparation method Methods 0.000 title description 7
- 239000000203 mixture Substances 0.000 claims abstract description 32
- 229920000642 polymer Polymers 0.000 claims abstract description 32
- 238000002513 implantation Methods 0.000 claims abstract description 31
- 230000003014 reinforcing effect Effects 0.000 claims abstract description 26
- 238000001356 surgical procedure Methods 0.000 claims abstract description 14
- 229920001577 copolymer Polymers 0.000 claims description 26
- 229920002988 biodegradable polymer Polymers 0.000 claims description 15
- 239000004621 biodegradable polymer Substances 0.000 claims description 15
- 241000283690 Bos taurus Species 0.000 claims description 12
- 108010010803 Gelatin Proteins 0.000 claims description 12
- 210000002805 bone matrix Anatomy 0.000 claims description 12
- 229920000159 gelatin Polymers 0.000 claims description 12
- 239000008273 gelatin Substances 0.000 claims description 12
- 235000019322 gelatine Nutrition 0.000 claims description 12
- 235000011852 gelatine desserts Nutrition 0.000 claims description 12
- -1 poly (amide esters Chemical class 0.000 claims description 10
- 230000001413 cellular effect Effects 0.000 claims description 9
- 229920000229 biodegradable polyester Polymers 0.000 claims description 8
- 239000004622 biodegradable polyester Substances 0.000 claims description 8
- 229920001245 poly(D,L-lactide-co-caprolactone) Polymers 0.000 claims description 7
- 229920000954 Polyglycolide Polymers 0.000 claims description 6
- 229920001610 polycaprolactone Polymers 0.000 claims description 6
- 229920000515 polycarbonate Polymers 0.000 claims description 6
- 239000004417 polycarbonate Substances 0.000 claims description 6
- 210000001519 tissue Anatomy 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 239000012298 atmosphere Substances 0.000 claims description 4
- 230000010261 cell growth Effects 0.000 claims description 4
- 238000009795 derivation Methods 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 150000004676 glycans Chemical class 0.000 claims description 4
- 239000004632 polycaprolactone Substances 0.000 claims description 4
- 239000004633 polyglycolic acid Substances 0.000 claims description 4
- 229920001282 polysaccharide Polymers 0.000 claims description 4
- 239000005017 polysaccharide Substances 0.000 claims description 4
- 229920002635 polyurethane Polymers 0.000 claims description 4
- 239000004814 polyurethane Substances 0.000 claims description 4
- 239000013557 residual solvent Substances 0.000 claims description 4
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims description 3
- 239000003462 bioceramic Substances 0.000 claims description 3
- 229920000249 biocompatible polymer Polymers 0.000 claims description 3
- 230000004663 cell proliferation Effects 0.000 claims description 3
- 239000000919 ceramic Substances 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 3
- 230000010354 integration Effects 0.000 claims description 3
- 239000011707 mineral Substances 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 229920000728 polyester Polymers 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- ZLUFYQVHJAVDHU-NSCUHMNNSA-N (6e)-2-methyl-2,3-dihydro-1,4-dioxocine-5,8-dione Chemical class CC1COC(=O)\C=C\C(=O)O1 ZLUFYQVHJAVDHU-NSCUHMNNSA-N 0.000 claims description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 2
- 229920000936 Agarose Polymers 0.000 claims description 2
- 229920001661 Chitosan Polymers 0.000 claims description 2
- 102000008186 Collagen Human genes 0.000 claims description 2
- 108010035532 Collagen Proteins 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
- 102000009123 Fibrin Human genes 0.000 claims description 2
- 108010073385 Fibrin Proteins 0.000 claims description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 2
- 102000008946 Fibrinogen Human genes 0.000 claims description 2
- 108010049003 Fibrinogen Proteins 0.000 claims description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 239000004952 Polyamide Substances 0.000 claims description 2
- 229920002732 Polyanhydride Polymers 0.000 claims description 2
- 239000004698 Polyethylene Substances 0.000 claims description 2
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims description 2
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 239000004793 Polystyrene Substances 0.000 claims description 2
- 229920002396 Polyurea Polymers 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 229930003316 Vitamin D Natural products 0.000 claims description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 2
- 230000021164 cell adhesion Effects 0.000 claims description 2
- 229920001436 collagen Polymers 0.000 claims description 2
- 230000003750 conditioning effect Effects 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 2
- 229950003499 fibrin Drugs 0.000 claims description 2
- 229940012952 fibrinogen Drugs 0.000 claims description 2
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Chemical compound C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 claims description 2
- 239000007952 growth promoter Substances 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 229920002674 hyaluronan Polymers 0.000 claims description 2
- 229960003160 hyaluronic acid Drugs 0.000 claims description 2
- 150000001261 hydroxy acids Chemical class 0.000 claims description 2
- 239000000411 inducer Substances 0.000 claims description 2
- 235000015097 nutrients Nutrition 0.000 claims description 2
- 229920001432 poly(L-lactide) Polymers 0.000 claims description 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 2
- 229920001308 poly(aminoacid) Polymers 0.000 claims description 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 2
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims description 2
- 229920000218 poly(hydroxyvalerate) Polymers 0.000 claims description 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 2
- 229920000058 polyacrylate Polymers 0.000 claims description 2
- 229920002647 polyamide Polymers 0.000 claims description 2
- 229920000767 polyaniline Polymers 0.000 claims description 2
- 229920001230 polyarylate Polymers 0.000 claims description 2
- 229920000573 polyethylene Polymers 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000004626 polylactic acid Substances 0.000 claims description 2
- 229920000193 polymethacrylate Polymers 0.000 claims description 2
- 229920006324 polyoxymethylene Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920000128 polypyrrole Polymers 0.000 claims description 2
- 229920002223 polystyrene Polymers 0.000 claims description 2
- 229920000123 polythiophene Polymers 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims description 2
- 235000003687 soy isoflavones Nutrition 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- 230000004936 stimulating effect Effects 0.000 claims description 2
- XXUZFRDUEGQHOV-UHFFFAOYSA-J strontium ranelate Chemical compound [Sr+2].[Sr+2].[O-]C(=O)CN(CC([O-])=O)C=1SC(C([O-])=O)=C(CC([O-])=O)C=1C#N XXUZFRDUEGQHOV-UHFFFAOYSA-J 0.000 claims description 2
- 229940079488 strontium ranelate Drugs 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 235000019166 vitamin D Nutrition 0.000 claims description 2
- 239000011710 vitamin D Substances 0.000 claims description 2
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 2
- 229940046008 vitamin d Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 150000002905 orthoesters Chemical class 0.000 claims 1
- 229920006209 poly(L-lactide-co-D,L-lactide) Polymers 0.000 claims 1
- 229920003055 poly(ester-imide) Polymers 0.000 claims 1
- 229920006149 polyester-amide block copolymer Polymers 0.000 claims 1
- 238000009849 vacuum degassing Methods 0.000 claims 1
- 230000000399 orthopedic effect Effects 0.000 abstract description 5
- 238000002278 reconstructive surgery Methods 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 20
- 210000004027 cell Anatomy 0.000 description 14
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
- 239000000463 material Substances 0.000 description 10
- 238000003756 stirring Methods 0.000 description 9
- 230000001054 cortical effect Effects 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 239000002131 composite material Substances 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 238000007872 degassing Methods 0.000 description 3
- 238000010899 nucleation Methods 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 238000000879 optical micrograph Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000009331 sowing Methods 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 208000001132 Osteoporosis Diseases 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000001612 chondrocyte Anatomy 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 230000001172 regenerating effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229920001710 Polyorthoester Polymers 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000002659 cell therapy Methods 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000007822 coupling agent Substances 0.000 description 1
- 239000004053 dental implant Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000002389 environmental scanning electron microscopy Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 230000004820 osteoconduction Effects 0.000 description 1
- 230000000278 osteoconductive effect Effects 0.000 description 1
- 230000004819 osteoinduction Effects 0.000 description 1
- 230000002138 osteoinductive effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Botany (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH01997/08A CH700138B1 (it) | 2008-12-19 | 2008-12-19 | Matrice per impianto osseo e procedimento di preparazione della stessa. |
| JP2011541629A JP5801719B2 (ja) | 2008-12-19 | 2009-12-15 | 骨インプラント基材及びその調製方法 |
| CN201710105757.0A CN106890361A (zh) | 2008-12-19 | 2009-12-15 | 骨植入物基质及其制备方法 |
| US13/128,062 US9770532B2 (en) | 2008-12-19 | 2009-12-15 | Bone implant matrix and method of preparing the same |
| ES09796449.8T ES2557105T3 (es) | 2008-12-19 | 2009-12-15 | Matriz de implante óseo y método para prepararla |
| PCT/IB2009/007759 WO2010070416A1 (en) | 2008-12-19 | 2009-12-15 | Bone implant matrix and method of preparing the same |
| EP09796449.8A EP2358407B1 (en) | 2008-12-19 | 2009-12-15 | Bone implant matrix and method of preparing the same |
| BRPI0923017-3A BRPI0923017B1 (pt) | 2008-12-19 | 2009-12-15 | Matriz para implantes ósseos |
| CN2009801507256A CN102256633A (zh) | 2008-12-19 | 2009-12-15 | 骨植入物基质及其制备方法 |
| RU2011126095/15A RU2532385C2 (ru) | 2008-12-19 | 2009-12-15 | Матрикс для костного имплантата и способ его получения |
| ZA2011/03322A ZA201103322B (en) | 2008-12-19 | 2011-05-06 | Bone implant matrix and method of preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH01997/08A CH700138B1 (it) | 2008-12-19 | 2008-12-19 | Matrice per impianto osseo e procedimento di preparazione della stessa. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CH700138A1 CH700138A1 (it) | 2010-06-30 |
| CH700138B1 true CH700138B1 (it) | 2012-12-14 |
Family
ID=40566331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH01997/08A CH700138B1 (it) | 2008-12-19 | 2008-12-19 | Matrice per impianto osseo e procedimento di preparazione della stessa. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9770532B2 (enExample) |
| EP (1) | EP2358407B1 (enExample) |
| JP (1) | JP5801719B2 (enExample) |
| CN (2) | CN106890361A (enExample) |
| BR (1) | BRPI0923017B1 (enExample) |
| CH (1) | CH700138B1 (enExample) |
| ES (1) | ES2557105T3 (enExample) |
| RU (1) | RU2532385C2 (enExample) |
| WO (1) | WO2010070416A1 (enExample) |
| ZA (1) | ZA201103322B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9452001B2 (en) * | 2005-02-22 | 2016-09-27 | Tecres S.P.A. | Disposable device for treatment of infections of human limbs |
| US11291483B2 (en) | 2010-10-20 | 2022-04-05 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants |
| US11207109B2 (en) * | 2010-10-20 | 2021-12-28 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| CA2863967C (en) | 2012-02-07 | 2021-02-09 | Lifenet Health | Liquefaction of bone matrix |
| EP3307287A4 (en) * | 2015-06-09 | 2018-12-19 | Orthocyte Corporation | Osteogenic graft forming unit |
| KR101671150B1 (ko) * | 2016-07-15 | 2016-10-31 | 가톨릭관동대학교산학협력단 | 안와벽용 임플란트 |
| RU2630464C1 (ru) * | 2016-07-29 | 2017-09-08 | Федеральное государственное бюджетное научное учреждение Всероссийский научно-исследовательский институт лекарственных и ароматических растений (ФГБНУ ВИЛАР) | Комбинированный способ стерилизации костных имплантатов |
| CN106581747A (zh) * | 2016-12-08 | 2017-04-26 | 山东明德生物医学工程有限公司 | 一种含锶骨水泥及制备方法 |
| IT201800002658A1 (it) * | 2018-02-13 | 2019-08-13 | Surgical Clinicare S R L | Dispositivo per impianto nello spazio intervertebrale e uso di matrice per impianti ossei in chirurgia vertebrale |
| CN108939150A (zh) * | 2018-09-05 | 2018-12-07 | 华东理工大学 | 基于POFC/β-TCP和雷尼酸锶的骨质疏松缺损修复用支架 |
| EP3714909A1 (en) * | 2019-03-28 | 2020-09-30 | Industrie Biomediche Insubri S.A. | Improved bone implant matrix comprising proline-rich peptide and method of preparing the same |
| EP3818994A1 (en) * | 2019-11-08 | 2021-05-12 | Septodont ou Septodont SAS ou Specialites Septodont | Non-breaking filament for shaping bone and dental substitutes |
| RU2758551C1 (ru) * | 2021-01-13 | 2021-10-29 | Общество с ограниченной ответственностью "Медлайн Компани" | Способ определения адсорбционной ёмкости гранулированного остеокондуктивного костнопластического материала |
| RU2758570C1 (ru) * | 2021-01-13 | 2021-10-29 | Общество с ограниченной ответственностью "Медлайн Компани" | Способ дегазации гранулированного остеокондуктивного костнопластического материала |
| IT202100005438A1 (it) | 2021-03-09 | 2022-09-09 | Pharmaexceed S R L | Scaffold per la rigenerazione ossea e relativo metodo di fabbricazione |
| EP4643893A1 (en) | 2024-04-30 | 2025-11-05 | Industrie Biomediche Insubri S.A. | A cold-cleaning process for deriving a decellularized graft tissue to be used as a medical device, or as a raw material |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6376573B1 (en) * | 1994-12-21 | 2002-04-23 | Interpore International | Porous biomaterials and methods for their manufacture |
| US20020076429A1 (en) * | 1998-01-28 | 2002-06-20 | John F. Wironen | Bone paste subjected to irradiative and thermal treatment |
| US6293970B1 (en) * | 1998-06-30 | 2001-09-25 | Lifenet | Plasticized bone and soft tissue grafts and methods of making and using same |
| WO2000015273A1 (de) * | 1998-09-11 | 2000-03-23 | Gerhard Schmidmaier | Biologisch aktive implantate |
| AU1593001A (en) | 1999-11-12 | 2001-06-06 | Fibrogen, Inc. | Recombinant gelatin in vaccines |
| US20040265385A1 (en) * | 2001-04-12 | 2004-12-30 | Therics, Inc. | Porous biostructure partially occupied by interpenetrant and method for making same |
| US20020183858A1 (en) * | 2001-06-05 | 2002-12-05 | Contiliano Joseph H. | Attachment of absorbable tissue scaffolds to scaffold fixation devices |
| JP5165823B2 (ja) | 2001-09-20 | 2013-03-21 | 株式会社ニッピ | ゼラチン加水分解物の成形方法 |
| EP3254710B1 (en) * | 2003-04-11 | 2019-05-22 | Etex Corporation | Osteoinductive bone material |
| WO2004098456A2 (en) * | 2003-05-01 | 2004-11-18 | Therics, Inc. | Porous biostructure partially occupied by interpenetrant and method for making same |
| US20050020506A1 (en) | 2003-07-25 | 2005-01-27 | Drapeau Susan J. | Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use |
| JP2007526085A (ja) | 2004-03-02 | 2007-09-13 | ナノセラピューティクス・インコーポレイテッド | 骨を修復するための組成物ならびにそのような組成物を調製および使用するための方法 |
| US20070224245A1 (en) * | 2006-02-08 | 2007-09-27 | Northwestern University | Poly (diol co-citrate) hydroxyapatite composite for tissue engineering and orthopaedic fixation devices |
| RU2322955C2 (ru) * | 2006-02-13 | 2008-04-27 | ГОУ ВПО Военно-медицинская академия им. С.М. Кирова | Способ изготовления имплантата для пластики дефектов хрящевой ткани |
| KR100846836B1 (ko) * | 2007-01-15 | 2008-07-17 | 한스바이오메드 주식회사 | 골재생촉진 조성물 |
| CA2710207C (en) * | 2007-12-21 | 2017-06-06 | Rti Biologics, Inc. | Osteoinductive putties and methods of making and using such putties |
-
2008
- 2008-12-19 CH CH01997/08A patent/CH700138B1/it unknown
-
2009
- 2009-12-15 CN CN201710105757.0A patent/CN106890361A/zh active Pending
- 2009-12-15 EP EP09796449.8A patent/EP2358407B1/en active Active
- 2009-12-15 WO PCT/IB2009/007759 patent/WO2010070416A1/en not_active Ceased
- 2009-12-15 RU RU2011126095/15A patent/RU2532385C2/ru active
- 2009-12-15 ES ES09796449.8T patent/ES2557105T3/es active Active
- 2009-12-15 JP JP2011541629A patent/JP5801719B2/ja active Active
- 2009-12-15 CN CN2009801507256A patent/CN102256633A/zh active Pending
- 2009-12-15 US US13/128,062 patent/US9770532B2/en active Active
- 2009-12-15 BR BRPI0923017-3A patent/BRPI0923017B1/pt active IP Right Grant
-
2011
- 2011-05-06 ZA ZA2011/03322A patent/ZA201103322B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012512684A (ja) | 2012-06-07 |
| EP2358407A1 (en) | 2011-08-24 |
| BRPI0923017B1 (pt) | 2019-02-19 |
| RU2011126095A (ru) | 2013-01-27 |
| US9770532B2 (en) | 2017-09-26 |
| EP2358407B1 (en) | 2015-12-09 |
| CN102256633A (zh) | 2011-11-23 |
| US20110218646A1 (en) | 2011-09-08 |
| WO2010070416A1 (en) | 2010-06-24 |
| RU2532385C2 (ru) | 2014-11-10 |
| CN106890361A (zh) | 2017-06-27 |
| BRPI0923017A2 (pt) | 2015-12-15 |
| CH700138A1 (it) | 2010-06-30 |
| ZA201103322B (en) | 2012-07-25 |
| JP5801719B2 (ja) | 2015-10-28 |
| ES2557105T3 (es) | 2016-01-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CH700138B1 (it) | Matrice per impianto osseo e procedimento di preparazione della stessa. | |
| CN102824657B (zh) | 骨修复材料及其制备方法 | |
| EP2517738B1 (en) | A collagen/hydroxyapatite composite scaffold | |
| ES2762118T3 (es) | Andamiajes tisulares regenerativos | |
| Fialkov et al. | In vivo bone engineering in a rabbit femur | |
| EP2682135A1 (en) | Non-woven fabric containing bone prosthetic material | |
| EP1976460A2 (en) | Injectable and moldable bone substitute materials | |
| JP2016005555A (ja) | 成型可能な骨代用材の生成 | |
| Calvo‐Guirado et al. | Retracted: Influence of Biphasic β‐TCP with and without the use of collagen membranes on bone healing of surgically critical size defects. A radiological, histological, and histomorphometric study | |
| KR101427305B1 (ko) | 골 이식재 및 그의 제조방법 | |
| Ali et al. | Advances in guided bone regeneration membranes: A comprehensive review of materials and techniques | |
| JP2022525813A (ja) | プロリンリッチペプチドを含む改良型骨インプラントマトリクスおよびその調製方法 | |
| Chen et al. | Reconstruction of calvarial defect using a tricalcium phosphate-oligomeric proanthocyanidins cross-linked gelatin composite | |
| Yuan et al. | Experimental study of natural hydroxyapatite/chitosan composite on reconstructing bone defects | |
| Macedo et al. | Bone integration behavior of hydroxyapatite/β-tricalcium phosphate graft implanted in dental alveoli: A histomorphometric and scanning electron microscopy study | |
| EP3877013B1 (en) | Bone sialoprotein functionalized materials for directed bone regeneration | |
| CN101947332A (zh) | 多孔可生物降解的复合型骨修复材料及制作方法 | |
| Yao et al. | Fabrication and evaluation of a new composite composed of tricalcium phosphate, gelatin and Chi-Li-Saan as a bone substitute | |
| Högset et al. | Plaster of Paris: Thermal Properties and Biocompatibility A Study on an Alternative Implant Material for Ear Surgery | |
| HK1233549A1 (zh) | 骨植入物基质及其制备方法 | |
| KR20240053692A (ko) | 매트리솜 함유 합성 고분자/천연 고분자 하이드로겔 기반 3d 스캐폴드 및 이의 제조방법 | |
| JP2025130730A (ja) | 多孔質骨誘導性複合体 | |
| HK1161143A (en) | Bone implant matrix and method of preparing the same | |
| Patrick | Fabrication and Characterization of Antibacterial Polycaprolactone and Natural Hydroxyapatite Nanofibers for Bone Tissue Scaffolds | |
| CN111068122A (zh) | 生物复合材料及其制备方法和生物支架 |