BRPI0923017B1 - Matriz para implantes ósseos - Google Patents
Matriz para implantes ósseos Download PDFInfo
- Publication number
- BRPI0923017B1 BRPI0923017B1 BRPI0923017-3A BRPI0923017A BRPI0923017B1 BR PI0923017 B1 BRPI0923017 B1 BR PI0923017B1 BR PI0923017 A BRPI0923017 A BR PI0923017A BR PI0923017 B1 BRPI0923017 B1 BR PI0923017B1
- Authority
- BR
- Brazil
- Prior art keywords
- matrix
- bone
- poly
- lactide
- copolymer
- Prior art date
Links
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 100
- 239000007943 implant Substances 0.000 title claims abstract description 62
- 239000011159 matrix material Substances 0.000 claims abstract description 76
- 239000000203 mixture Substances 0.000 claims abstract description 37
- 229920000642 polymer Polymers 0.000 claims abstract description 31
- 230000002787 reinforcement Effects 0.000 claims abstract description 30
- 229920001577 copolymer Polymers 0.000 claims description 38
- 210000002805 bone matrix Anatomy 0.000 claims description 25
- 108010010803 Gelatin Proteins 0.000 claims description 23
- 229920000159 gelatin Polymers 0.000 claims description 23
- 239000008273 gelatin Substances 0.000 claims description 23
- 235000019322 gelatine Nutrition 0.000 claims description 23
- 235000011852 gelatine desserts Nutrition 0.000 claims description 23
- 241000283690 Bos taurus Species 0.000 claims description 20
- 229920000229 biodegradable polyester Polymers 0.000 claims description 12
- 239000004622 biodegradable polyester Substances 0.000 claims description 12
- 239000002904 solvent Substances 0.000 claims description 11
- 229920001245 poly(D,L-lactide-co-caprolactone) Polymers 0.000 claims description 9
- 210000001519 tissue Anatomy 0.000 claims description 9
- 229920001610 polycaprolactone Polymers 0.000 claims description 8
- 239000004626 polylactic acid Substances 0.000 claims description 8
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- 239000004632 polycaprolactone Substances 0.000 claims description 7
- 230000010261 cell growth Effects 0.000 claims description 6
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- 239000000126 substance Substances 0.000 claims description 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 3
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- 239000002253 acid Substances 0.000 claims 1
- KOWWOODYPWDWOJ-LVBPXUMQSA-N elatine Chemical compound C([C@]12CN(C3[C@@]45OCO[C@]44[C@H]6[C@@H](OC)[C@@H]([C@H](C4)OC)C[C@H]6[C@@]3([C@@H]1[C@@H]5OC)[C@@H](OC)CC2)CC)OC(=O)C1=CC=CC=C1N1C(=O)CC(C)C1=O KOWWOODYPWDWOJ-LVBPXUMQSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 18
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- 230000000399 orthopedic effect Effects 0.000 abstract description 5
- 239000000243 solution Substances 0.000 description 43
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 24
- 210000004027 cell Anatomy 0.000 description 17
- 238000003756 stirring Methods 0.000 description 13
- 239000000463 material Substances 0.000 description 11
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 10
- 229920002988 biodegradable polymer Polymers 0.000 description 9
- 239000004621 biodegradable polymer Substances 0.000 description 9
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 208000001132 Osteoporosis Diseases 0.000 description 2
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- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- ZLUFYQVHJAVDHU-NSCUHMNNSA-N (6e)-2-methyl-2,3-dihydro-1,4-dioxocine-5,8-dione Chemical class CC1COC(=O)\C=C\C(=O)O1 ZLUFYQVHJAVDHU-NSCUHMNNSA-N 0.000 description 1
- OCKGFTQIICXDQW-ZEQRLZLVSA-N 5-[(1r)-1-hydroxy-2-[4-[(2r)-2-hydroxy-2-(4-methyl-1-oxo-3h-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3h-2-benzofuran-1-one Chemical compound C1=C2C(=O)OCC2=C(C)C([C@@H](O)CN2CCN(CC2)C[C@H](O)C2=CC=C3C(=O)OCC3=C2C)=C1 OCKGFTQIICXDQW-ZEQRLZLVSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
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- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
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- 239000007822 coupling agent Substances 0.000 description 1
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- 230000002328 demineralizing effect Effects 0.000 description 1
- 239000004053 dental implant Substances 0.000 description 1
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- 238000002389 environmental scanning electron microscopy Methods 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 235000006539 genistein Nutrition 0.000 description 1
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 description 1
- 229940045109 genistein Drugs 0.000 description 1
- ZCOLJUOHXJRHDI-CMWLGVBASA-N genistein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
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- 229920002674 hyaluronan Polymers 0.000 description 1
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- 150000001261 hydroxy acids Chemical class 0.000 description 1
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- 230000003287 optical effect Effects 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 230000004820 osteoconduction Effects 0.000 description 1
- 230000004819 osteoinduction Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 description 1
- 229920001308 poly(aminoacid) Polymers 0.000 description 1
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- 229920000218 poly(hydroxyvalerate) Polymers 0.000 description 1
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- 229920000128 polypyrrole Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
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- 235000003687 soy isoflavones Nutrition 0.000 description 1
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- 239000008107 starch Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- XXUZFRDUEGQHOV-UHFFFAOYSA-J strontium ranelate Chemical compound [Sr+2].[Sr+2].[O-]C(=O)CN(CC([O-])=O)C=1SC(C([O-])=O)=C(CC([O-])=O)C=1C#N XXUZFRDUEGQHOV-UHFFFAOYSA-J 0.000 description 1
- 229940079488 strontium ranelate Drugs 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Botany (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH01997/08 | 2008-12-19 | ||
| CH01997/08A CH700138B1 (it) | 2008-12-19 | 2008-12-19 | Matrice per impianto osseo e procedimento di preparazione della stessa. |
| PCT/IB2009/007759 WO2010070416A1 (en) | 2008-12-19 | 2009-12-15 | Bone implant matrix and method of preparing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0923017A2 BRPI0923017A2 (pt) | 2015-12-15 |
| BRPI0923017B1 true BRPI0923017B1 (pt) | 2019-02-19 |
Family
ID=40566331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0923017-3A BRPI0923017B1 (pt) | 2008-12-19 | 2009-12-15 | Matriz para implantes ósseos |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9770532B2 (enExample) |
| EP (1) | EP2358407B1 (enExample) |
| JP (1) | JP5801719B2 (enExample) |
| CN (2) | CN106890361A (enExample) |
| BR (1) | BRPI0923017B1 (enExample) |
| CH (1) | CH700138B1 (enExample) |
| ES (1) | ES2557105T3 (enExample) |
| RU (1) | RU2532385C2 (enExample) |
| WO (1) | WO2010070416A1 (enExample) |
| ZA (1) | ZA201103322B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9452001B2 (en) * | 2005-02-22 | 2016-09-27 | Tecres S.P.A. | Disposable device for treatment of infections of human limbs |
| US11291483B2 (en) | 2010-10-20 | 2022-04-05 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants |
| US11207109B2 (en) * | 2010-10-20 | 2021-12-28 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| CA2863967C (en) | 2012-02-07 | 2021-02-09 | Lifenet Health | Liquefaction of bone matrix |
| EP3307287A4 (en) * | 2015-06-09 | 2018-12-19 | Orthocyte Corporation | Osteogenic graft forming unit |
| KR101671150B1 (ko) * | 2016-07-15 | 2016-10-31 | 가톨릭관동대학교산학협력단 | 안와벽용 임플란트 |
| RU2630464C1 (ru) * | 2016-07-29 | 2017-09-08 | Федеральное государственное бюджетное научное учреждение Всероссийский научно-исследовательский институт лекарственных и ароматических растений (ФГБНУ ВИЛАР) | Комбинированный способ стерилизации костных имплантатов |
| CN106581747A (zh) * | 2016-12-08 | 2017-04-26 | 山东明德生物医学工程有限公司 | 一种含锶骨水泥及制备方法 |
| IT201800002658A1 (it) * | 2018-02-13 | 2019-08-13 | Surgical Clinicare S R L | Dispositivo per impianto nello spazio intervertebrale e uso di matrice per impianti ossei in chirurgia vertebrale |
| CN108939150A (zh) * | 2018-09-05 | 2018-12-07 | 华东理工大学 | 基于POFC/β-TCP和雷尼酸锶的骨质疏松缺损修复用支架 |
| EP3714909A1 (en) * | 2019-03-28 | 2020-09-30 | Industrie Biomediche Insubri S.A. | Improved bone implant matrix comprising proline-rich peptide and method of preparing the same |
| EP3818994A1 (en) * | 2019-11-08 | 2021-05-12 | Septodont ou Septodont SAS ou Specialites Septodont | Non-breaking filament for shaping bone and dental substitutes |
| RU2758551C1 (ru) * | 2021-01-13 | 2021-10-29 | Общество с ограниченной ответственностью "Медлайн Компани" | Способ определения адсорбционной ёмкости гранулированного остеокондуктивного костнопластического материала |
| RU2758570C1 (ru) * | 2021-01-13 | 2021-10-29 | Общество с ограниченной ответственностью "Медлайн Компани" | Способ дегазации гранулированного остеокондуктивного костнопластического материала |
| IT202100005438A1 (it) | 2021-03-09 | 2022-09-09 | Pharmaexceed S R L | Scaffold per la rigenerazione ossea e relativo metodo di fabbricazione |
| EP4643893A1 (en) | 2024-04-30 | 2025-11-05 | Industrie Biomediche Insubri S.A. | A cold-cleaning process for deriving a decellularized graft tissue to be used as a medical device, or as a raw material |
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| US6376573B1 (en) * | 1994-12-21 | 2002-04-23 | Interpore International | Porous biomaterials and methods for their manufacture |
| US20020076429A1 (en) * | 1998-01-28 | 2002-06-20 | John F. Wironen | Bone paste subjected to irradiative and thermal treatment |
| US6293970B1 (en) * | 1998-06-30 | 2001-09-25 | Lifenet | Plasticized bone and soft tissue grafts and methods of making and using same |
| WO2000015273A1 (de) * | 1998-09-11 | 2000-03-23 | Gerhard Schmidmaier | Biologisch aktive implantate |
| AU1593001A (en) | 1999-11-12 | 2001-06-06 | Fibrogen, Inc. | Recombinant gelatin in vaccines |
| US20040265385A1 (en) * | 2001-04-12 | 2004-12-30 | Therics, Inc. | Porous biostructure partially occupied by interpenetrant and method for making same |
| US20020183858A1 (en) * | 2001-06-05 | 2002-12-05 | Contiliano Joseph H. | Attachment of absorbable tissue scaffolds to scaffold fixation devices |
| JP5165823B2 (ja) | 2001-09-20 | 2013-03-21 | 株式会社ニッピ | ゼラチン加水分解物の成形方法 |
| EP3254710B1 (en) * | 2003-04-11 | 2019-05-22 | Etex Corporation | Osteoinductive bone material |
| WO2004098456A2 (en) * | 2003-05-01 | 2004-11-18 | Therics, Inc. | Porous biostructure partially occupied by interpenetrant and method for making same |
| US20050020506A1 (en) | 2003-07-25 | 2005-01-27 | Drapeau Susan J. | Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use |
| JP2007526085A (ja) | 2004-03-02 | 2007-09-13 | ナノセラピューティクス・インコーポレイテッド | 骨を修復するための組成物ならびにそのような組成物を調製および使用するための方法 |
| US20070224245A1 (en) * | 2006-02-08 | 2007-09-27 | Northwestern University | Poly (diol co-citrate) hydroxyapatite composite for tissue engineering and orthopaedic fixation devices |
| RU2322955C2 (ru) * | 2006-02-13 | 2008-04-27 | ГОУ ВПО Военно-медицинская академия им. С.М. Кирова | Способ изготовления имплантата для пластики дефектов хрящевой ткани |
| KR100846836B1 (ko) * | 2007-01-15 | 2008-07-17 | 한스바이오메드 주식회사 | 골재생촉진 조성물 |
| CA2710207C (en) * | 2007-12-21 | 2017-06-06 | Rti Biologics, Inc. | Osteoinductive putties and methods of making and using such putties |
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| JP2012512684A (ja) | 2012-06-07 |
| EP2358407A1 (en) | 2011-08-24 |
| CH700138B1 (it) | 2012-12-14 |
| RU2011126095A (ru) | 2013-01-27 |
| US9770532B2 (en) | 2017-09-26 |
| EP2358407B1 (en) | 2015-12-09 |
| CN102256633A (zh) | 2011-11-23 |
| US20110218646A1 (en) | 2011-09-08 |
| WO2010070416A1 (en) | 2010-06-24 |
| RU2532385C2 (ru) | 2014-11-10 |
| CN106890361A (zh) | 2017-06-27 |
| BRPI0923017A2 (pt) | 2015-12-15 |
| CH700138A1 (it) | 2010-06-30 |
| ZA201103322B (en) | 2012-07-25 |
| JP5801719B2 (ja) | 2015-10-28 |
| ES2557105T3 (es) | 2016-01-22 |
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/12/2009, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/12/2009, OBSERVADAS AS CONDICOES LEGAIS |