ES2557105T3 - Matriz de implante óseo y método para prepararla - Google Patents
Matriz de implante óseo y método para prepararla Download PDFInfo
- Publication number
- ES2557105T3 ES2557105T3 ES09796449.8T ES09796449T ES2557105T3 ES 2557105 T3 ES2557105 T3 ES 2557105T3 ES 09796449 T ES09796449 T ES 09796449T ES 2557105 T3 ES2557105 T3 ES 2557105T3
- Authority
- ES
- Spain
- Prior art keywords
- cell
- matrix
- gelatin
- polymer
- copolymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000011159 matrix material Substances 0.000 title abstract description 8
- 210000000988 bone and bone Anatomy 0.000 title abstract description 5
- 239000007943 implant Substances 0.000 title abstract description 3
- 238000000034 method Methods 0.000 title description 2
- 229920000642 polymer Polymers 0.000 abstract description 9
- 108010010803 Gelatin Proteins 0.000 abstract description 8
- 229920001577 copolymer Polymers 0.000 abstract description 8
- 229920000159 gelatin Polymers 0.000 abstract description 8
- 239000008273 gelatin Substances 0.000 abstract description 8
- 235000019322 gelatine Nutrition 0.000 abstract description 8
- 235000011852 gelatine desserts Nutrition 0.000 abstract description 8
- 241000283690 Bos taurus Species 0.000 abstract description 6
- 210000002805 bone matrix Anatomy 0.000 abstract description 6
- 239000000203 mixture Substances 0.000 abstract description 5
- 239000002904 solvent Substances 0.000 abstract description 5
- 230000001413 cellular effect Effects 0.000 abstract description 2
- 239000006185 dispersion Substances 0.000 abstract description 2
- 230000003014 reinforcing effect Effects 0.000 abstract description 2
- 230000002787 reinforcement Effects 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 230000009286 beneficial effect Effects 0.000 abstract 2
- 229920000229 biodegradable polyester Polymers 0.000 abstract 2
- 239000004622 biodegradable polyester Substances 0.000 abstract 2
- 230000010261 cell growth Effects 0.000 abstract 2
- 230000010354 integration Effects 0.000 abstract 2
- 210000001519 tissue Anatomy 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002318 adhesion promoter Substances 0.000 abstract 1
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 239000007952 growth promoter Substances 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 20
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- 238000003756 stirring Methods 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 3
- 241000282898 Sus scrofa Species 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000001054 cortical effect Effects 0.000 description 2
- 238000013019 agitation Methods 0.000 description 1
- 238000002389 environmental scanning electron microscopy Methods 0.000 description 1
- 239000007970 homogeneous dispersion Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229920001245 poly(D,L-lactide-co-caprolactone) Polymers 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Botany (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH19972008 | 2008-12-19 | ||
| CH01997/08A CH700138B1 (it) | 2008-12-19 | 2008-12-19 | Matrice per impianto osseo e procedimento di preparazione della stessa. |
| PCT/IB2009/007759 WO2010070416A1 (en) | 2008-12-19 | 2009-12-15 | Bone implant matrix and method of preparing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2557105T3 true ES2557105T3 (es) | 2016-01-22 |
Family
ID=40566331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09796449.8T Active ES2557105T3 (es) | 2008-12-19 | 2009-12-15 | Matriz de implante óseo y método para prepararla |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9770532B2 (enExample) |
| EP (1) | EP2358407B1 (enExample) |
| JP (1) | JP5801719B2 (enExample) |
| CN (2) | CN106890361A (enExample) |
| BR (1) | BRPI0923017B1 (enExample) |
| CH (1) | CH700138B1 (enExample) |
| ES (1) | ES2557105T3 (enExample) |
| RU (1) | RU2532385C2 (enExample) |
| WO (1) | WO2010070416A1 (enExample) |
| ZA (1) | ZA201103322B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9452001B2 (en) * | 2005-02-22 | 2016-09-27 | Tecres S.P.A. | Disposable device for treatment of infections of human limbs |
| US11291483B2 (en) | 2010-10-20 | 2022-04-05 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants |
| US11207109B2 (en) * | 2010-10-20 | 2021-12-28 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| CA2863967C (en) | 2012-02-07 | 2021-02-09 | Lifenet Health | Liquefaction of bone matrix |
| EP3307287A4 (en) * | 2015-06-09 | 2018-12-19 | Orthocyte Corporation | Osteogenic graft forming unit |
| KR101671150B1 (ko) * | 2016-07-15 | 2016-10-31 | 가톨릭관동대학교산학협력단 | 안와벽용 임플란트 |
| RU2630464C1 (ru) * | 2016-07-29 | 2017-09-08 | Федеральное государственное бюджетное научное учреждение Всероссийский научно-исследовательский институт лекарственных и ароматических растений (ФГБНУ ВИЛАР) | Комбинированный способ стерилизации костных имплантатов |
| CN106581747A (zh) * | 2016-12-08 | 2017-04-26 | 山东明德生物医学工程有限公司 | 一种含锶骨水泥及制备方法 |
| IT201800002658A1 (it) * | 2018-02-13 | 2019-08-13 | Surgical Clinicare S R L | Dispositivo per impianto nello spazio intervertebrale e uso di matrice per impianti ossei in chirurgia vertebrale |
| CN108939150A (zh) * | 2018-09-05 | 2018-12-07 | 华东理工大学 | 基于POFC/β-TCP和雷尼酸锶的骨质疏松缺损修复用支架 |
| EP3714909A1 (en) * | 2019-03-28 | 2020-09-30 | Industrie Biomediche Insubri S.A. | Improved bone implant matrix comprising proline-rich peptide and method of preparing the same |
| EP3818994A1 (en) * | 2019-11-08 | 2021-05-12 | Septodont ou Septodont SAS ou Specialites Septodont | Non-breaking filament for shaping bone and dental substitutes |
| RU2758551C1 (ru) * | 2021-01-13 | 2021-10-29 | Общество с ограниченной ответственностью "Медлайн Компани" | Способ определения адсорбционной ёмкости гранулированного остеокондуктивного костнопластического материала |
| RU2758570C1 (ru) * | 2021-01-13 | 2021-10-29 | Общество с ограниченной ответственностью "Медлайн Компани" | Способ дегазации гранулированного остеокондуктивного костнопластического материала |
| IT202100005438A1 (it) | 2021-03-09 | 2022-09-09 | Pharmaexceed S R L | Scaffold per la rigenerazione ossea e relativo metodo di fabbricazione |
| EP4643893A1 (en) | 2024-04-30 | 2025-11-05 | Industrie Biomediche Insubri S.A. | A cold-cleaning process for deriving a decellularized graft tissue to be used as a medical device, or as a raw material |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6376573B1 (en) * | 1994-12-21 | 2002-04-23 | Interpore International | Porous biomaterials and methods for their manufacture |
| US20020076429A1 (en) * | 1998-01-28 | 2002-06-20 | John F. Wironen | Bone paste subjected to irradiative and thermal treatment |
| US6293970B1 (en) * | 1998-06-30 | 2001-09-25 | Lifenet | Plasticized bone and soft tissue grafts and methods of making and using same |
| WO2000015273A1 (de) * | 1998-09-11 | 2000-03-23 | Gerhard Schmidmaier | Biologisch aktive implantate |
| AU1593001A (en) | 1999-11-12 | 2001-06-06 | Fibrogen, Inc. | Recombinant gelatin in vaccines |
| US20040265385A1 (en) * | 2001-04-12 | 2004-12-30 | Therics, Inc. | Porous biostructure partially occupied by interpenetrant and method for making same |
| US20020183858A1 (en) * | 2001-06-05 | 2002-12-05 | Contiliano Joseph H. | Attachment of absorbable tissue scaffolds to scaffold fixation devices |
| JP5165823B2 (ja) | 2001-09-20 | 2013-03-21 | 株式会社ニッピ | ゼラチン加水分解物の成形方法 |
| EP3254710B1 (en) * | 2003-04-11 | 2019-05-22 | Etex Corporation | Osteoinductive bone material |
| WO2004098456A2 (en) * | 2003-05-01 | 2004-11-18 | Therics, Inc. | Porous biostructure partially occupied by interpenetrant and method for making same |
| US20050020506A1 (en) | 2003-07-25 | 2005-01-27 | Drapeau Susan J. | Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use |
| JP2007526085A (ja) | 2004-03-02 | 2007-09-13 | ナノセラピューティクス・インコーポレイテッド | 骨を修復するための組成物ならびにそのような組成物を調製および使用するための方法 |
| US20070224245A1 (en) * | 2006-02-08 | 2007-09-27 | Northwestern University | Poly (diol co-citrate) hydroxyapatite composite for tissue engineering and orthopaedic fixation devices |
| RU2322955C2 (ru) * | 2006-02-13 | 2008-04-27 | ГОУ ВПО Военно-медицинская академия им. С.М. Кирова | Способ изготовления имплантата для пластики дефектов хрящевой ткани |
| KR100846836B1 (ko) * | 2007-01-15 | 2008-07-17 | 한스바이오메드 주식회사 | 골재생촉진 조성물 |
| CA2710207C (en) * | 2007-12-21 | 2017-06-06 | Rti Biologics, Inc. | Osteoinductive putties and methods of making and using such putties |
-
2008
- 2008-12-19 CH CH01997/08A patent/CH700138B1/it unknown
-
2009
- 2009-12-15 CN CN201710105757.0A patent/CN106890361A/zh active Pending
- 2009-12-15 EP EP09796449.8A patent/EP2358407B1/en active Active
- 2009-12-15 WO PCT/IB2009/007759 patent/WO2010070416A1/en not_active Ceased
- 2009-12-15 RU RU2011126095/15A patent/RU2532385C2/ru active
- 2009-12-15 ES ES09796449.8T patent/ES2557105T3/es active Active
- 2009-12-15 JP JP2011541629A patent/JP5801719B2/ja active Active
- 2009-12-15 CN CN2009801507256A patent/CN102256633A/zh active Pending
- 2009-12-15 US US13/128,062 patent/US9770532B2/en active Active
- 2009-12-15 BR BRPI0923017-3A patent/BRPI0923017B1/pt active IP Right Grant
-
2011
- 2011-05-06 ZA ZA2011/03322A patent/ZA201103322B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012512684A (ja) | 2012-06-07 |
| EP2358407A1 (en) | 2011-08-24 |
| BRPI0923017B1 (pt) | 2019-02-19 |
| CH700138B1 (it) | 2012-12-14 |
| RU2011126095A (ru) | 2013-01-27 |
| US9770532B2 (en) | 2017-09-26 |
| EP2358407B1 (en) | 2015-12-09 |
| CN102256633A (zh) | 2011-11-23 |
| US20110218646A1 (en) | 2011-09-08 |
| WO2010070416A1 (en) | 2010-06-24 |
| RU2532385C2 (ru) | 2014-11-10 |
| CN106890361A (zh) | 2017-06-27 |
| BRPI0923017A2 (pt) | 2015-12-15 |
| CH700138A1 (it) | 2010-06-30 |
| ZA201103322B (en) | 2012-07-25 |
| JP5801719B2 (ja) | 2015-10-28 |
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