CH667274A5 - Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents

Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen. Download PDF

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Publication number
CH667274A5
CH667274A5 CH1194/85A CH119485A CH667274A5 CH 667274 A5 CH667274 A5 CH 667274A5 CH 1194/85 A CH1194/85 A CH 1194/85A CH 119485 A CH119485 A CH 119485A CH 667274 A5 CH667274 A5 CH 667274A5
Authority
CH
Switzerland
Prior art keywords
cyclosporin
val
nva
mebmt
formula
Prior art date
Application number
CH1194/85A
Other languages
German (de)
English (en)
Inventor
Roland Dr Wenger
Rene P Dr Traber
Hans Dr Kobel
Hans Hofmann
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848407618A external-priority patent/GB8407618D0/en
Priority claimed from GB848411922A external-priority patent/GB8411922D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of CH667274A5 publication Critical patent/CH667274A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CH1194/85A 1984-03-23 1985-03-18 Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen. CH667274A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848407618A GB8407618D0 (en) 1984-03-23 1984-03-23 Organic compounds
GB848411922A GB8411922D0 (en) 1984-05-10 1984-05-10 Organic compounds

Publications (1)

Publication Number Publication Date
CH667274A5 true CH667274A5 (de) 1988-09-30

Family

ID=26287502

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1194/85A CH667274A5 (de) 1984-03-23 1985-03-18 Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Country Status (24)

Country Link
US (1) US4639434A (forum.php)
JP (1) JPH08838B2 (forum.php)
AT (1) AT388737B (forum.php)
BE (1) BE901980A (forum.php)
CA (1) CA1247546A (forum.php)
CH (1) CH667274A5 (forum.php)
CS (1) CS249542B2 (forum.php)
DE (1) DE3509809A1 (forum.php)
DK (1) DK128285A (forum.php)
ES (1) ES8702926A1 (forum.php)
FI (1) FI851120L (forum.php)
FR (1) FR2561651B1 (forum.php)
GB (1) GB2155936B (forum.php)
GR (1) GR850716B (forum.php)
HU (1) HU200786B (forum.php)
IL (1) IL74681A (forum.php)
IT (1) IT1199962B (forum.php)
LU (1) LU85819A1 (forum.php)
NL (1) NL8500828A (forum.php)
NO (1) NO851160L (forum.php)
NZ (1) NZ211526A (forum.php)
PH (2) PH21868A (forum.php)
PT (1) PT80149B (forum.php)
SE (1) SE461334B (forum.php)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY1915A (en) 1984-10-04 1985-09-27 Sandoz Ag Cyclosporins
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
DE3884470T2 (de) * 1987-06-17 1994-03-10 Sandoz Ag Cyclosporine und deren Benutzung als Arzneimittel.
EP0373260B1 (en) * 1987-06-22 1994-03-09 Merck & Co. Inc. Cyclosporin derivatives with modified "8-amino acid"
US5227467A (en) * 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
JPH0667850B2 (ja) * 1987-09-03 1994-08-31 ユニバーシティ オブ ジョージア リサーチ ファウンデーション，インコーポレイテッド 眼科用サイクロスポリン組成物
US5089390A (en) * 1987-09-04 1992-02-18 Syntex (U.S.A.) Inc. 2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivatives
US5236899A (en) * 1987-11-16 1993-08-17 Merck & Co., Inc. 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
CH679119A5 (forum.php) * 1988-05-13 1991-12-31 Sandoz Ag
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5202310A (en) * 1990-06-06 1993-04-13 Levy Gary A Cyclosporine metabolites
ATE148469T1 (de) 1990-11-02 1997-02-15 Sandoz Ag Zyklosporine
ES2181734T3 (es) 1990-11-20 2003-03-01 Dade Behring Marburg Gmbh Ensayo inmunologico de ciclosporina.
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
RU2170741C2 (ru) * 1996-08-16 2001-07-20 Новартис Аг Способ получения циклоспорина
ATE314388T1 (de) 1997-10-08 2006-01-15 Isotechnika Inc Deuterierte und undeuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agentien
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
US5990274A (en) 1997-11-25 1999-11-23 Dade Behring Inc. Cyclosporine derivatives and uses thereof
US7449544B2 (en) * 1999-11-30 2008-11-11 Cyclacel Limited p21 peptides
JP4261355B2 (ja) 2001-10-19 2009-04-30 アイソテクニカ インコーポレイテッド シクロスポリン類似体の合成法
NZ531946A (en) * 2001-10-19 2005-09-30 Isotechnika Inc Preconcentrate formulations comprising cyclosporin analogue microemulsions that reduce adverse effects while maintaining high bioavailability
WO2004082629A2 (en) * 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
WO2006039164A2 (en) * 2004-09-29 2006-04-13 Amr Technology, Inc. Novel cyclosporin analogues and their pharmaceutical uses
EP1809656A4 (en) * 2004-09-29 2009-03-25 Amr Technology Inc CYCLOSPORINAL KINANALOGA AND ITS PHARMACEUTICAL APPLICATIONS
WO2006041631A2 (en) * 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7576057B2 (en) 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
KR102011339B1 (ko) 2010-12-15 2019-08-16 콘트라빌 파마슈티컬스, 인코퍼레이티드 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자
AU2012229236B2 (en) 2011-03-11 2017-05-18 Beth Israel Deaconess Medical Center, Inc. Anti-CD40 antibodies and uses thereof
CN104877013B (zh) * 2015-06-03 2018-04-20 兰州大学 环孢菌素t及其制备方法和应用
BR112018004296B1 (pt) 2015-09-04 2020-05-05 Primatope Therapeutics Inc anticorpos anti-cd40 humanizados e usos dos mesmos

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57140753A (en) * 1981-01-09 1982-08-31 Sandoz Ag Novel cyclosporine
DE3260468D1 (en) * 1981-01-09 1984-09-06 Sandoz Ag Novel cyclosporins

Also Published As

Publication number Publication date
IL74681A0 (en) 1985-06-30
FI851120A7 (fi) 1985-09-24
GB8507270D0 (en) 1985-04-24
FI851120A0 (fi) 1985-03-20
IT8547852A0 (it) 1985-03-22
GB2155936B (en) 1987-09-16
FR2561651A1 (fr) 1985-09-27
GR850716B (forum.php) 1985-07-19
SE8501392D0 (sv) 1985-03-21
DK128285A (da) 1985-09-24
DK128285D0 (da) 1985-03-21
SE8501392L (sv) 1985-09-24
NL8500828A (nl) 1985-10-16
NZ211526A (en) 1988-08-30
PH21868A (en) 1988-03-25
NO851160L (no) 1985-09-24
LU85819A1 (fr) 1985-12-12
ES541465A0 (es) 1987-01-16
HU200786B (en) 1990-08-28
US4639434A (en) 1987-01-27
AT388737B (de) 1989-08-25
SE461334B (sv) 1990-02-05
GB2155936A (en) 1985-10-02
HUT38370A (en) 1986-05-28
IL74681A (en) 1989-09-10
FR2561651B1 (fr) 1990-03-09
IT8547852A1 (it) 1986-09-22
JPS60215700A (ja) 1985-10-29
CS249542B2 (en) 1987-03-12
IT1199962B (it) 1989-01-05
PT80149B (en) 1987-03-23
PT80149A (en) 1985-04-01
BE901980A (fr) 1985-09-23
PH23357A (en) 1989-07-14
JPH08838B2 (ja) 1996-01-10
ES8702926A1 (es) 1987-01-16
ATA86385A (de) 1989-01-15
CA1247546A (en) 1988-12-28
FI851120L (fi) 1985-09-24
DE3509809A1 (de) 1986-01-09

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Legal Events

Date Code Title Description
PFA Name/firm changed

Owner name: SANDOZ AG TRANSFER- NOVARTIS AG

PL Patent ceased