CH629534A5 - Verfahren zur herstellung von penicillinen und cephalosporinen. - Google Patents
Verfahren zur herstellung von penicillinen und cephalosporinen. Download PDFInfo
- Publication number
- CH629534A5 CH629534A5 CH608076A CH608076A CH629534A5 CH 629534 A5 CH629534 A5 CH 629534A5 CH 608076 A CH608076 A CH 608076A CH 608076 A CH608076 A CH 608076A CH 629534 A5 CH629534 A5 CH 629534A5
- Authority
- CH
- Switzerland
- Prior art keywords
- acid
- methyl ester
- salts
- aphanocladium
- phenylglycine
- Prior art date
Links
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- 238000000034 method Methods 0.000 claims description 26
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- 150000007942 carboxylates Chemical class 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 108700039708 galantide Proteins 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000003898 horticulture Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- DWKPPFQULDPWHX-VKHMYHEASA-N l-alanyl ester Chemical compound COC(=O)[C@H](C)N DWKPPFQULDPWHX-VKHMYHEASA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- FFEARJCKVFRZRR-UHFFFAOYSA-N methionine Chemical compound CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 1
- 229960004452 methionine Drugs 0.000 description 1
- BHFLUDRTVIDDOR-MRVPVSSYSA-N methyl (2r)-2-amino-2-phenylacetate Chemical compound COC(=O)[C@H](N)C1=CC=CC=C1 BHFLUDRTVIDDOR-MRVPVSSYSA-N 0.000 description 1
- ANSUDRATXSJBLY-VKHMYHEASA-N methyl (2s)-2-amino-3-hydroxypropanoate Chemical compound COC(=O)[C@@H](N)CO ANSUDRATXSJBLY-VKHMYHEASA-N 0.000 description 1
- KCUNTYMNJVXYKZ-UHFFFAOYSA-N methyl 2-amino-3-(1h-indol-3-yl)propanoate Chemical compound C1=CC=C2C(CC(N)C(=O)OC)=CNC2=C1 KCUNTYMNJVXYKZ-UHFFFAOYSA-N 0.000 description 1
- ANSUDRATXSJBLY-UHFFFAOYSA-N methyl 2-amino-3-hydroxypropanoate Chemical compound COC(=O)C(N)CO ANSUDRATXSJBLY-UHFFFAOYSA-N 0.000 description 1
- VSDUZFOSJDMAFZ-UHFFFAOYSA-N methyl 2-amino-3-phenylpropanoate Chemical compound COC(=O)C(N)CC1=CC=CC=C1 VSDUZFOSJDMAFZ-UHFFFAOYSA-N 0.000 description 1
- DWKPPFQULDPWHX-UHFFFAOYSA-N methyl 2-aminopropanoate Chemical compound COC(=O)C(C)N DWKPPFQULDPWHX-UHFFFAOYSA-N 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000001226 reprecipitation Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/925—Cephalosporium
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP50057844A JPS51133488A (en) | 1975-05-14 | 1975-05-14 | Process for producing antibiotics enzymatically |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH629534A5 true CH629534A5 (de) | 1982-04-30 |
Family
ID=13067273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH608076A CH629534A5 (de) | 1975-05-14 | 1976-05-14 | Verfahren zur herstellung von penicillinen und cephalosporinen. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4073687A (OSRAM) |
| JP (1) | JPS51133488A (OSRAM) |
| CA (1) | CA1049431A (OSRAM) |
| CH (1) | CH629534A5 (OSRAM) |
| DE (1) | DE2621618A1 (OSRAM) |
| FR (1) | FR2310757A1 (OSRAM) |
| GB (1) | GB1544844A (OSRAM) |
| NL (1) | NL7605138A (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5645196A (en) * | 1979-09-19 | 1981-04-24 | Shionogi & Co Ltd | Enzymatic synthesis of beta-lactam antibacterial agent |
| DE68926548T2 (de) * | 1988-04-26 | 1996-09-26 | Gist Brocades Nv | Verfahren zur enzymatischen Herstellung von beta-Lactamen |
| DK1641933T3 (en) * | 2003-07-03 | 2018-03-26 | Dsm Sinochem Pharm Nl Bv | PROCEDURE FOR MANUFACTURING CEFRADIN |
| CN100507000C (zh) * | 2003-07-03 | 2009-07-01 | 帝斯曼知识产权资产管理有限公司 | 制备头孢拉定的方法 |
| WO2012175585A1 (en) | 2011-06-23 | 2012-12-27 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Process for preparing 3'-thiosubstituted cephalosporins employing a penicillin g acylase |
| EP2723881A2 (en) | 2011-06-23 | 2014-04-30 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Novel crystalline cefoperazone intermediate |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5548797B1 (OSRAM) * | 1971-04-02 | 1980-12-08 | ||
| JPS5231436B2 (OSRAM) * | 1971-08-20 | 1977-08-15 | ||
| US3761354A (en) * | 1972-03-27 | 1973-09-25 | Toyo Jozo Kk | Process for the production of cephalexin |
| JPS5513719B2 (OSRAM) * | 1972-12-06 | 1980-04-10 | ||
| CH590292A5 (OSRAM) * | 1973-12-20 | 1977-07-29 | Ciba Geigy Ag |
-
1975
- 1975-05-14 JP JP50057844A patent/JPS51133488A/ja active Pending
-
1976
- 1976-05-11 CA CA252,220A patent/CA1049431A/en not_active Expired
- 1976-05-12 US US05/686,219 patent/US4073687A/en not_active Expired - Lifetime
- 1976-05-13 NL NL7605138A patent/NL7605138A/xx not_active Application Discontinuation
- 1976-05-13 FR FR7614498A patent/FR2310757A1/fr active Granted
- 1976-05-14 GB GB20087/76A patent/GB1544844A/en not_active Expired
- 1976-05-14 CH CH608076A patent/CH629534A5/de not_active IP Right Cessation
- 1976-05-14 DE DE19762621618 patent/DE2621618A1/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA1049431A (en) | 1979-02-27 |
| FR2310757B1 (OSRAM) | 1980-10-24 |
| US4073687A (en) | 1978-02-14 |
| GB1544844A (en) | 1979-04-25 |
| FR2310757A1 (fr) | 1976-12-10 |
| DE2621618A1 (de) | 1976-11-25 |
| NL7605138A (nl) | 1976-11-16 |
| JPS51133488A (en) | 1976-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |