CH625530A5 - - Google Patents

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Publication number
CH625530A5
CH625530A5 CH887076A CH887076A CH625530A5 CH 625530 A5 CH625530 A5 CH 625530A5 CH 887076 A CH887076 A CH 887076A CH 887076 A CH887076 A CH 887076A CH 625530 A5 CH625530 A5 CH 625530A5
Authority
CH
Switzerland
Prior art keywords
anhydro
isomer
vlb
formula
sulfuric acid
Prior art date
Application number
CH887076A
Other languages
German (de)
English (en)
Inventor
Gerald Edward Gutowski
Jean Corinne Miller
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CH625530A5 publication Critical patent/CH625530A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CH887076A 1975-07-10 1976-07-09 CH625530A5 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/594,915 US4029663A (en) 1975-07-10 1975-07-10 Dimeric anhydro-vinca derivatives

Publications (1)

Publication Number Publication Date
CH625530A5 true CH625530A5 (ja) 1981-09-30

Family

ID=24380952

Family Applications (1)

Application Number Title Priority Date Filing Date
CH887076A CH625530A5 (ja) 1975-07-10 1976-07-09

Country Status (12)

Country Link
US (1) US4029663A (ja)
JP (1) JPS5210300A (ja)
BE (1) BE843950A (ja)
CA (1) CA1057750A (ja)
CH (1) CH625530A5 (ja)
DE (1) DE2630392A1 (ja)
FR (1) FR2316950A1 (ja)
GB (1) GB1548621A (ja)
HU (1) HU179457B (ja)
IE (1) IE43113B1 (ja)
IL (1) IL49706A (ja)
NL (1) NL7607549A (ja)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2296418B1 (ja) * 1974-12-30 1978-07-21 Anvar
US4279817A (en) * 1975-05-30 1981-07-21 The United States Of America As Represented By The Department Of Health & Human Services Method for producing dimer alkaloids
USRE30561E (en) * 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
US4160767A (en) * 1976-12-06 1979-07-10 Eli Lilly And Company Vinca alkaloid intermediates
US4143041A (en) * 1977-01-19 1979-03-06 Eli Lilly And Company 4'-Deoxyvincristine and related compounds
US4166810A (en) * 1978-04-20 1979-09-04 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide
AR225153A1 (es) * 1978-10-10 1982-02-26 Lilly Co Eli Un procedimiento para la preparacion de sulfato de vindesina
US4639456A (en) * 1980-06-10 1987-01-27 Omnichem S.A. Vinblastin-23-oyl amino acid derivatives
US4322351A (en) * 1980-08-25 1982-03-30 Eli Lilly And Company Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
US4320058A (en) * 1980-12-29 1982-03-16 Eli Lilly And Company 20'-Hydroxyvinblastine and related compounds
HU185691B (en) * 1982-02-09 1985-03-28 Richter Gedeon Vegyeszet Process for preparing a new analgetic pharmaceutical composition
DK167984A (da) * 1983-03-30 1984-10-01 Lilly Industries Ltd Alkaloidderivater
HU193772B (en) * 1985-06-12 1987-11-30 Richter Gedeon Vegyeszet Process for producing new nitro-bis-indole derivatives
US6011041A (en) * 1995-07-28 2000-01-04 University Of British Columbia Use of anhydrovinblastine
CA2219095A1 (en) 1997-03-04 1998-09-04 Bruce Schmidt Anhydrovinblastine for the treatment of cervical and lung cancer
AU783029B2 (en) * 1997-03-04 2005-09-15 University Of British Columbia, The Anhydrovinblastine for the treatment of cervical and lung cancer
US20030162803A1 (en) * 1997-03-04 2003-08-28 Bruce Schmidt Anhydrovinblastine for the treatment of cancer
US6841537B1 (en) 1998-04-22 2005-01-11 Protiva Biotherapeutics Inc. Combination therapy using nucleic acids and conventional drugs
US6841538B1 (en) 1998-04-22 2005-01-11 Inex Pharmaceuticals Corporation Combination therapy using nucleic acids and radio therapy
CA2325561A1 (en) * 1998-04-22 1999-10-28 Inex Pharmaceuticals Corporation Combination therapy using nucleic acids and conventional drugs
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2005086922A2 (en) 2004-03-10 2005-09-22 Board Of Regents, University Of Texas System Oncolytic adenovirus armed with therapeutic genes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3352868A (en) * 1964-04-01 1967-11-14 Lilly Co Eli Dihydrovinblastine

Also Published As

Publication number Publication date
JPS5210300A (en) 1977-01-26
FR2316950B1 (ja) 1980-10-17
FR2316950A1 (fr) 1977-02-04
IL49706A (en) 1979-09-30
NL7607549A (nl) 1977-01-12
IE43113B1 (en) 1980-12-17
JPS6220192B2 (ja) 1987-05-06
GB1548621A (en) 1979-07-18
BE843950A (fr) 1977-01-10
DE2630392A1 (de) 1977-02-03
CA1057750A (en) 1979-07-03
US4029663A (en) 1977-06-14
IL49706A0 (en) 1976-08-31
IE43113L (en) 1977-01-10
HU179457B (en) 1982-10-28

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Legal Events

Date Code Title Description
PL Patent ceased