CH602633A5 - - Google Patents

Info

Publication number
CH602633A5
CH602633A5 CH170477A CH170477A CH602633A5 CH 602633 A5 CH602633 A5 CH 602633A5 CH 170477 A CH170477 A CH 170477A CH 170477 A CH170477 A CH 170477A CH 602633 A5 CH602633 A5 CH 602633A5
Authority
CH
Switzerland
Application number
CH170477A
Inventor
David Wayne Cushman
Miguel Angel Ondetti
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of CH602633A5 publication Critical patent/CH602633A5/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CH170477A 1976-02-13 1977-02-11 CH602633A5 (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/657,793 US4052511A (en) 1976-02-13 1976-02-13 Carboxyacylproline derivatives

Publications (1)

Publication Number Publication Date
CH602633A5 true CH602633A5 (lt) 1978-07-31

Family

ID=24638684

Family Applications (1)

Application Number Title Priority Date Filing Date
CH170477A CH602633A5 (lt) 1976-02-13 1977-02-11

Country Status (23)

Country Link
US (3) US4052511A (lt)
JP (1) JPS6058751B2 (lt)
AT (1) AT366030B (lt)
BE (1) BE851363A (lt)
CA (1) CA1104059A (lt)
CH (1) CH602633A5 (lt)
CS (1) CS197285B2 (lt)
DD (1) DD129651A5 (lt)
DE (1) DE2704985A1 (lt)
DK (1) DK59077A (lt)
FR (1) FR2340933A1 (lt)
GB (1) GB1570921A (lt)
HU (1) HU177144B (lt)
IE (1) IE45086B1 (lt)
NL (1) NL167688C (lt)
NO (1) NO145915C (lt)
NZ (1) NZ183222A (lt)
PH (1) PH12066A (lt)
PL (1) PL106416B1 (lt)
SE (1) SE426169B (lt)
SU (1) SU694070A3 (lt)
YU (1) YU33277A (lt)
ZA (1) ZA77564B (lt)

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US4241076A (en) * 1978-02-21 1980-12-23 E. R. Squibb & Sons, Inc. Halogenated substituted mercaptoacylamino acids
US4154935A (en) * 1978-02-21 1979-05-15 E. R. Squibb & Sons, Inc. Halogen substituted mercaptoacylamino acids
US4179568A (en) * 1978-07-31 1979-12-18 E. R. Squibb & Sons, Inc. (N-lower alkyl-3,5-dioxo-3-pyrrolidinyl)thioalkanoylpyrrolidine-and piperidine-carboxylic acid compounds
JPS584711B2 (ja) * 1978-08-02 1983-01-27 参天製薬株式会社 ピロリジン誘導体
US4154934A (en) * 1978-08-11 1979-05-15 E. R. Squibb & Sons, Inc. Mercaptoacylamino derivatives of heterocyclic carboxylic acids
JPS5531022A (en) * 1978-08-24 1980-03-05 Yoshitomi Pharmaceut Ind Ltd Hydroxamic acid derivative and its preparation
US4226775A (en) * 1979-06-01 1980-10-07 American Cyanamid Company Substituted thio-substituted benzyl-propionyl-L-prolines
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US4690938A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4690937A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4698355A (en) * 1979-08-14 1987-10-06 University Of Miami Anti-hypertensive agents
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
US4695577A (en) * 1979-08-14 1987-09-22 University Of Miami Anti-hypertensive agents
US4690939A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4698356A (en) * 1979-08-14 1987-10-06 University Of Miami Anti-hypertensive agents
US4690940A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
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US4291040A (en) * 1979-10-22 1981-09-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
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US4587050A (en) * 1980-08-18 1986-05-06 Merck & Co., Inc. Substituted enantholactam derivatives as antihypertensives
US4629787A (en) * 1980-08-18 1986-12-16 Merck & Co., Inc. Substituted caprolactam derivatives as antihypertensives
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4409146A (en) * 1980-10-06 1983-10-11 Merck & Co., Inc. Substituted caprolactam derivatives as antihypertensives
US4311705A (en) * 1980-10-06 1982-01-19 E. R. Squibb & Sons, Inc. Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
US4390700A (en) * 1980-11-10 1983-06-28 Ciba-Geigy Corporation 1-Carboxyazaalkanoyl-tetrahydroquinoline-2-carboxylic acids
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
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US4321383A (en) * 1980-11-24 1982-03-23 E. R. Squibb & Sons, Inc. Heterobicyclo intermediates
US4303662A (en) * 1980-11-24 1981-12-01 E. R. Squibb & Sons, Inc. Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds
US4401818A (en) * 1980-12-24 1983-08-30 Ciba-Geigy Corporation 1-Carboxyalkanoyl-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
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US4587238A (en) * 1981-07-06 1986-05-06 Merck & Co., Inc. Substituted caprylolactam derivatives as anti-hypertensives
US4866087A (en) * 1982-01-21 1989-09-12 Merck & Co., Inc. Carboxyalkyl urea compounds and derivatives thereof useful as angiotensin converting enzyme inhibitors and as antihypertensives
US4483850A (en) * 1982-05-10 1984-11-20 Merck & Co., Inc. N-Terminal substituted oligopeptide converting enzyme inhibitors
US4634716A (en) * 1982-09-30 1987-01-06 Merck & Co., Inc. Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents
US4587234A (en) * 1982-11-18 1986-05-06 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
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US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
US4472384A (en) * 1983-06-15 1984-09-18 Merck & Co., Inc. Antihypertensive composition
US4617301A (en) * 1983-06-22 1986-10-14 Merck & Co., Inc. Sulfoxide and sulfone derivatives of bicyclic lactams as antihypertensives
US4558037A (en) * 1984-06-04 1985-12-10 Merck & Co., Inc. Cardiovascular composition
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US4939261A (en) * 1984-06-08 1990-07-03 Ciba-Geigy Corporation N-substituted butyramide derivatives useful for treatment of conditions responsive to inhibition of enkephalinase
US4678800A (en) * 1984-06-15 1987-07-07 Ciba-Geigy Corporation Gamma-r-glutamoyl derivatives
US4568489A (en) * 1984-06-29 1986-02-04 E. R. Squibb & Sons, Inc. N-Acyl-γ-glutamyl imino and amino acids and esters
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JP6546988B2 (ja) 2014-05-02 2019-07-17 エクセルシオール・メディカル・コーポレイションＥｘｃｅｌｓｉｏｒ Ｍｅｄｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ 防腐キャップのためのストリップパッケージ
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US11541220B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Needleless connector with antimicrobial properties
US11400195B2 (en) 2018-11-07 2022-08-02 Icu Medical, Inc. Peritoneal dialysis transfer set with antimicrobial properties
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US3335145A (en) * 1963-03-07 1967-08-08 Reilly Tar & Chem Corp N-carboxyacyl- and n-carboxyaroylcarboxy piperidines

Also Published As

Publication number Publication date
FR2340933B1 (lt) 1980-04-11
SE7701562L (sv) 1977-09-23
NO145915C (no) 1982-06-23
HU177144B (en) 1981-07-28
ZA77564B (en) 1977-12-28
US4128653A (en) 1978-12-05
US4086338A (en) 1978-04-25
PH12066A (en) 1978-10-18
BE851363A (fr) 1977-08-11
IE45086L (en) 1977-08-13
NL167688C (nl) 1982-01-18
YU33277A (en) 1982-08-31
SE426169B (sv) 1982-12-13
NL7701463A (nl) 1977-08-16
IE45086B1 (en) 1982-06-16
JPS52100461A (en) 1977-08-23
PL195997A1 (pl) 1978-02-27
DE2704985A1 (de) 1977-08-18
NO145915B (no) 1982-03-15
DK59077A (da) 1977-08-14
AT366030B (de) 1982-03-10
ATA96977A (de) 1981-07-15
NO770465L (no) 1977-08-16
NL167688B (nl) 1981-08-17
GB1570921A (en) 1980-07-09
US4052511A (en) 1977-10-04
FR2340933A1 (fr) 1977-09-09
SU694070A3 (ru) 1979-10-25
PL106416B1 (pl) 1979-12-31
CS197285B2 (en) 1980-04-30
CA1104059A (en) 1981-06-30
AU2189877A (en) 1978-08-10
DD129651A5 (de) 1978-02-01
NZ183222A (en) 1979-07-11
JPS6058751B2 (ja) 1985-12-21

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