CH500203A - Verfahren zur Herstellung von Nucleosiden - Google Patents

Verfahren zur Herstellung von Nucleosiden

Info

Publication number
CH500203A
CH500203A CH1012866A CH1012866A CH500203A CH 500203 A CH500203 A CH 500203A CH 1012866 A CH1012866 A CH 1012866A CH 1012866 A CH1012866 A CH 1012866A CH 500203 A CH500203 A CH 500203A
Authority
CH
Switzerland
Prior art keywords
alkyl
groups
protected
fluoro
tri
Prior art date
Application number
CH1012866A
Other languages
German (de)
English (en)
Inventor
Duschinsky Robert
Francis Gabriel Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CH500203A publication Critical patent/CH500203A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH1012866A 1965-07-22 1966-07-11 Verfahren zur Herstellung von Nucleosiden CH500203A (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47417565A 1965-07-22 1965-07-22
US474145A US3354160A (en) 1965-07-22 1965-07-22 Tri-lower alkyl-silyl-5-fluoropyrimidines

Publications (1)

Publication Number Publication Date
CH500203A true CH500203A (de) 1970-12-15

Family

ID=27044368

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1012866A CH500203A (de) 1965-07-22 1966-07-11 Verfahren zur Herstellung von Nucleosiden

Country Status (8)

Country Link
US (1) US3354160A (en, 2012)
BE (1) BE684319A (en, 2012)
BR (1) BR6681446D0 (en, 2012)
CH (1) CH500203A (en, 2012)
DE (1) DE1695151A1 (en, 2012)
GB (1) GB1080491A (en, 2012)
NL (1) NL145557B (en, 2012)
SE (1) SE320077B (en, 2012)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3479334A (en) * 1967-09-29 1969-11-18 Upjohn Co Process for selectively preparing lincomycin 7 - acylates and 7-carbonates
US3514440A (en) * 1968-01-23 1970-05-26 Upjohn Co 7-epimers of lincomycin and related compounds and processes for making the same
US3868373A (en) * 1970-01-27 1975-02-25 Hoffmann La Roche 4-Amino-5-fluoro-2-tri(lower alkyl) silyloxypyrimidines
DE2122991C2 (de) * 1971-05-04 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden
US3919193A (en) * 1973-07-06 1975-11-11 Icn Pharmaceuticals 3-Deazaguanosine and derivatives thereof
JPS5540598B2 (en, 2012) * 1974-05-15 1980-10-18
DE2508312A1 (de) * 1975-02-24 1976-09-02 Schering Ag Neues verfahren zur herstellung von nucleosiden
DE2514275A1 (de) * 1975-03-27 1976-10-14 Schering Ag Verfahren zur herstellung von n- (polysaccharidyl)-stickstoffheterocyclen, insbesondere von pyrimidin- oder purinbasen
DE2648239C3 (de) * 1975-10-24 1981-11-12 Rikagaku Kenkyusho, Wako, Saitama Di-(trialkylstannyl)-pyrimidinderivate, Verfahren zu ihrer Herstellung und Verfahren zu ihrer Weiterverarbeitung zu nucleosidartigen Pyrimidinderivaten
US4024143A (en) * 1976-03-11 1977-05-17 Pcr, Inc. Silylation of 5-fluoro-6-hydroxy or alkoxy pyrimidine
DE2621645C3 (de) * 1976-05-13 1981-08-06 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von Aminoderivaten von N-Heterocyclen
US4048432A (en) * 1976-05-17 1977-09-13 Parke, Davis & Company 9-(3,5-Di-O-acyl-β-D-arabinofuranosyl)adenine compounds and method for their production
US4055717A (en) * 1976-05-17 1977-10-25 Parke, Davis & Company 9-(3-O-Acyl-β-D-arabinofuranosyl)adenine compounds, 9-(2,3-di-O-acyl-β-D-arabinofuranosyl)-adenine compounds, and method for their production
DE2721466A1 (de) * 1977-05-12 1978-11-16 Robugen Gmbh Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden
DE2757365A1 (de) * 1977-12-20 1979-06-21 Schering Ag Neues verfahren zur herstellung von nucleosiden
GB2060604B (en) * 1979-10-03 1983-11-23 Univ Birmingham And Stichting E15-(2-halogenovinyl)-2'-deoxycytidines
DE3685315D1 (de) * 1985-07-22 1992-06-17 Teijin Ltd Antivirus-heilmittel.
EP0851866B1 (en) * 1995-06-23 2001-08-29 Oxford GlycoSciences (UK) Limited Therapeutic compounds
DK2252594T3 (en) * 2008-01-22 2015-11-23 Dow Agrosciences Llc 4-amino-5-fluoro-pyrimidine derivatives as fungicides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155646A (en) * 1960-08-23 1964-11-03 Upjohn Co 1-arabinofuranosyl-5-halouracil and process for the preparation thereof
US3183226A (en) * 1961-01-10 1965-05-11 Upjohn Co Process for transforming 1-beta-d-xylofuranosyluracil nucleosides into 1-beta-d-arabinofuranosyluracil nucleosides
GB1070413A (en) * 1962-11-15 1967-06-01 Sankyo Co A process for preparing purine and pyrimidine nucleosides

Also Published As

Publication number Publication date
US3354160A (en) 1967-11-21
GB1080491A (en) 1967-08-23
BR6681446D0 (pt) 1973-12-26
NL145557B (nl) 1975-04-15
BE684319A (en, 2012) 1967-01-19
SE320077B (en, 2012) 1970-02-02
DE1695151A1 (de) 1970-12-17
NL6610360A (en, 2012) 1967-01-23

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Legal Events

Date Code Title Description
PL Patent ceased