CH394235A - Procédé de préparation de l'iodhydrate de lysine - Google Patents
Procédé de préparation de l'iodhydrate de lysineInfo
- Publication number
- CH394235A CH394235A CH884261A CH884261A CH394235A CH 394235 A CH394235 A CH 394235A CH 884261 A CH884261 A CH 884261A CH 884261 A CH884261 A CH 884261A CH 394235 A CH394235 A CH 394235A
- Authority
- CH
- Switzerland
- Prior art keywords
- lysine hydrochloride
- lysine
- solution
- sub
- reaction
- Prior art date
Links
- 229960005337 lysine hydrochloride Drugs 0.000 title claims description 18
- BVHLGVCQOALMSV-JEDNCBNOSA-N L-lysine hydrochloride Chemical compound Cl.NCCCC[C@H](N)C(O)=O BVHLGVCQOALMSV-JEDNCBNOSA-N 0.000 title claims description 17
- 238000000034 method Methods 0.000 title claims description 8
- 238000002360 preparation method Methods 0.000 title description 3
- 239000004472 Lysine Substances 0.000 claims description 5
- 229960003646 lysine Drugs 0.000 claims description 5
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 239000003960 organic solvent Substances 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 239000000376 reactant Substances 0.000 claims description 2
- 239000012429 reaction media Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000243 solution Substances 0.000 description 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 239000011630 iodine Substances 0.000 description 4
- 229910052740 iodine Inorganic materials 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 230000003054 hormonal effect Effects 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 238000004448 titration Methods 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 2
- 229910001651 emery Inorganic materials 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229940071870 hydroiodic acid Drugs 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000004580 weight loss Effects 0.000 description 2
- SBZKOWAPPRXYGA-XRIGFGBMSA-N (2s)-2,6-diaminohexanoic acid;dihydrate Chemical compound O.O.NCCCC[C@H](N)C(O)=O SBZKOWAPPRXYGA-XRIGFGBMSA-N 0.000 description 1
- QLOKJRIVRGCVIM-UHFFFAOYSA-N 1-[(4-methylsulfanylphenyl)methyl]piperazine Chemical compound C1=CC(SC)=CC=C1CN1CCNCC1 QLOKJRIVRGCVIM-UHFFFAOYSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 231100000668 minimum lethal dose Toxicity 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Polyamides (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR834516A FR81M (hr) | 1960-07-29 | 1960-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH394235A true CH394235A (fr) | 1965-06-30 |
Family
ID=8736585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH884261A CH394235A (fr) | 1960-07-29 | 1961-07-27 | Procédé de préparation de l'iodhydrate de lysine |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE606635A (hr) |
| CH (1) | CH394235A (hr) |
| ES (1) | ES269439A1 (hr) |
| FR (1) | FR81M (hr) |
-
1960
- 1960-07-29 FR FR834516A patent/FR81M/fr active Active
-
1961
- 1961-07-27 BE BE606635A patent/BE606635A/fr unknown
- 1961-07-27 CH CH884261A patent/CH394235A/fr unknown
- 1961-07-28 ES ES0269439A patent/ES269439A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES269439A1 (es) | 1962-01-01 |
| FR81M (hr) | 1961-01-09 |
| BE606635A (fr) | 1961-11-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2001520670A (ja) | 芳香族及び複素環の硝酸誘導体 | |
| CH394235A (fr) | Procédé de préparation de l'iodhydrate de lysine | |
| CH394199A (fr) | Procédé de préparation de nicotinate de lysine | |
| CA2182112A1 (fr) | Derives de n,n'-di(aralkyl) n,n'-di(carboxyalkyl) alkylene di- ou triamine et de n-(aralkyl) n'-(carboxyalkyl) n,n'-di(carboxyalkyl) alkylene di- ou triamine et leur utilisation en pharmacie et en cosmetique | |
| CH394236A (fr) | Procédé de préparation de l'iodhydrate de lysine | |
| US3870792A (en) | Certain dihydrophthalizines for treating hemorrhage and thrombosis | |
| WO1981002295A1 (fr) | Phenoxyisobutyrates de moroxydine et medicaments les contenant | |
| CA1140155A (fr) | PROCEDE DE PREPARATION D'UN NOUVEAU DERIVE DU 1.alpha.,25-DIHYDROXY CHOLECALCIFEROL | |
| US6060498A (en) | Composition containing antitumor agent | |
| CH637650A5 (fr) | Procede de preparation d'un acide chromone carboxylique. | |
| US3592852A (en) | Substituted benzylideneamino guanidine | |
| CH394231A (fr) | Procédé de préparation d'acétyl-tryptophanate d'amphétamine | |
| CH665634A5 (en) | Stable soluble catechin complexes - with a double salt of L-lysine, for liver protection and digestive ulcers | |
| EP0135510A1 (fr) | Nouveaux medicaments appartenant a la famille des derives d'halo genobenzophenone-oxime. | |
| US3317391A (en) | Composition for treatment of angina pectoris and process for preparing same | |
| WO1998017673A1 (en) | Isosorbide aspirinate esters | |
| FR2682677A1 (fr) | Complexe forme de l'acide propyl-2 pentene-2 ouique (e) et de son sel de sodium, sa preparation et compositions pharmaceutiques le contenant. | |
| US4120958A (en) | Novel 2-acetoxybenzoic acid-nicotinamide complexes | |
| CA1189526A (fr) | Procede de preparation de nouveaux derives amines de l'acide 4-phenyl 4-oxo 2-butenoique et de leurs sels | |
| JPS6011693B2 (ja) | アセチルサリチル酸誘導体、その製造法ならびにそれを含有してなる解熱鎮痛剤および炎症抑制剤 | |
| FR3110396A1 (fr) | Composition comprenant un composé ascorbo-camphorate métallique pour son utilisation dans le traitement des infections causées par herpèsvirus | |
| CN115160399A (zh) | 一种皂皮酸类化合物及其制备方法和医用用途 | |
| LU83440A1 (fr) | N-oxyde de 4-methoxy-n-(2-(2-(1-methyl-2-piperidyl)ethyl)phenyl)benzamide et son procede de preparation | |
| CH259253A (fr) | Procédé de préparation de l'oléate d'acétylcholine. | |
| LU83081A1 (fr) | Compositions antitumeurs |