CH276857A - Process for the preparation of a new aldehyde derivative. - Google Patents
Process for the preparation of a new aldehyde derivative.Info
- Publication number
- CH276857A CH276857A CH276857DA CH276857A CH 276857 A CH276857 A CH 276857A CH 276857D A CH276857D A CH 276857DA CH 276857 A CH276857 A CH 276857A
- Authority
- CH
- Switzerland
- Prior art keywords
- works
- aldehyde derivative
- oxymethylamide
- nicotinic acid
- new
- Prior art date
Links
Landscapes
- Pyridine Compounds (AREA)
Description
<B>Verfahren zur Herstellung eines neuen</B> Aldehydderivates. Gegenstand des Patentes ist ein Verfah ren zur Herstellung eines neuen Aldehyd derivates, welches dadurch gekennzeichnet ist, dass man auf Nicotinsäure-oxymethylamid Cetylbromid einwirken lässt. Die Umsetzung wird vorzugsweise bei erhöhter Temperatur und in einem geschlossenen Gefäss, in An- oder Abwesenheit von Lösungsmitteln, durch geführt.
Das so erhaltene Ni-Brom-Ni-eetyl- nicotinsäure-oxymethylamid bildet farblose Kristalle, die bei 219 bis 2200 unter Zersetzung schmelzen und in heissem Wasser und den üblichen organischen Lösungsmitteln in der Wärme gut löslich sind. Die neue Verbindung soll als Chemotherapeuticum und als Zwi schenprodukt Verwendung finden. <I>Beispiel:</I> 50 g Nicotinsäure-oxymethylamid werden mit 600 cms Dioxan und 120 g Cetylbromid im Autoklaven 31 Stunden auf 100 bis 1101 erhitzt.
Nach dem Erkalten wird das Lösungs mittel abgegossen und der teilweise kristalline Rückstand aus Äthanol/Essigester umgefällt. Man erhält 122 g Ni-Brom-Ni-cetyl-nicotin- säure-oxymethylamid, was einer Ausbeute von 78,9 % der Theorie entspricht. Die neue Ver- bindung schmilzt. bei 219 bis 2200 und löst sich in den üblichen organischen Lösungsmit- teln in der Wärme gut.
Sie lässt sich durch Umkristallisation aus Äthanol gut reinigen.
<B> Process for the production of a new </B> aldehyde derivative. The subject of the patent is a process for the production of a new aldehyde derivative, which is characterized in that nicotinic acid oxymethylamide cetyl bromide is allowed to act. The reaction is preferably carried out at an elevated temperature and in a closed vessel, in the presence or absence of solvents.
The Ni-bromo-Ni-ethyl nicotinic acid oxymethylamide thus obtained forms colorless crystals which melt at 219 to 2200 with decomposition and are readily soluble in hot water and the usual organic solvents at high temperatures. The new compound should be used as a chemotherapeutic agent and as an intermediate product. <I> Example: </I> 50 g of nicotinic acid oxymethylamide are heated to 100 to 1101 for 31 hours with 600 cms of dioxane and 120 g of cetyl bromide in an autoclave.
After cooling, the solvent is poured off and the partially crystalline residue is reprecipitated from ethanol / ethyl acetate. 122 g of Ni-bromo-Ni-cetyl-nicotinic acid-oxymethylamide are obtained, which corresponds to a yield of 78.9% of theory. The new connection melts. at 219 to 2200 and dissolves well in common organic solvents when heated.
It can be easily cleaned by recrystallization from ethanol.
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH276857T | 1949-07-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH276857A true CH276857A (en) | 1951-07-31 |
Family
ID=4480956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH276857D CH276857A (en) | 1949-07-12 | 1949-07-12 | Process for the preparation of a new aldehyde derivative. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH276857A (en) |
-
1949
- 1949-07-12 CH CH276857D patent/CH276857A/en unknown
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