CH309830A - Process for producing a hydrazine compound. - Google Patents

Process for producing a hydrazine compound.

Info

Publication number
CH309830A
CH309830A CH309830DA CH309830A CH 309830 A CH309830 A CH 309830A CH 309830D A CH309830D A CH 309830DA CH 309830 A CH309830 A CH 309830A
Authority
CH
Switzerland
Prior art keywords
producing
hydrazine compound
compound
piperidino
hydrazine
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellschaft Ciba
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of CH309830A publication Critical patent/CH309830A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals

Description

  

  Verfahren zur Herstellung einer     Hydrazinverbindung.       Gegenstand des vorliegenden Patentes ist  ein Verfahren zur Herstellung des in der  Schweizer Patentschrift     Nr.262276    beschrie  benen 1,4 -     Dihydrazino    -     plithalazins,    welches       dadurch    gekennzeichnet ist, dass man eine       Verbindung    der     Poianel     
EMI0001.0008     
    worin X     lind    Y austauschfähige     Substituenten     und wenigstens einer davon eine     Amino-          -ruppe    bedeuten, mit     Hydrazin    umsetzt.  



  Die Umsetzung wird zweckmässig in     An-          wesenheit    von Verdünnungsmitteln, allenfalls       auch    in Gegenwart von Kondensationsmitteln,  vorteilhaft bei erhöhter Temperatur,     durch-          #-"eführt.    Sofern die als Ausgangsstoffe ver  wendeten Verbindungen neu sind, lassen sie  sieh nach an sich bekannten     Methoden    ge  winneu.

      <I>Beispiel:</I>  1     Gewichtsteil        1.-Piperidino-4-clilor-phtlial-          azin    werden in einem Gemisch von 5     Volum-          l        eilen        Hi        drazinhydrat    und 2     Volumteilen          n-Pi-olivlalkohol    während einiger Stunden  zum Sieden erhitzt.

   Nach dem Erkalten und  anschliessendem 2tägigem Stehen bei etwa. 0   wird das gebildete     1,4-Dihvdrazino-phthalazin          abgesaugt.    Durch     Umkristallisieren    aus Was-         ser,    wobei die heisse Lösung filtriert wird,  erhält man das Produkt rein; F. = 189  un  ter Zersetzung. Man kann aus dem Rohpro  dukt direkt das Sulfat vom F. = 236      (Zers.)          gewinnen        durch    Aufnehmen in wenig heisser       2-n-Schwefelsäure.     



  Das als     ALugangsprodukt    verwendete     Pi-          peridino-clilor-plithalazin    wird leicht aus     Di-          elilorplitlialazin    und     Piperidin    durch Erwär  men der Komponenten in     benzoliseher    Lösung  erhalten. Es     scldhilzt    bei     132 .  



  Process for producing a hydrazine compound. The subject of the present patent is a process for the production of the 1,4-dihydrazino-plithalazine described in Swiss patent specification No. 262276, which is characterized in that a compound of Poianel is used
EMI0001.0008
    wherein X and Y are exchangeable substituents and at least one of them is an amino group, is reacted with hydrazine.



  The reaction is expediently carried out in the presence of diluents, possibly also in the presence of condensing agents, advantageously at elevated temperature. If the compounds used as starting materials are new, they can be obtained by methods known per se .

      <I> Example: </I> 1 part by weight of 1.-piperidino-4-clilor-phtlialazine is heated to the boil for a few hours in a mixture of 5 parts by volume of hi-drazinhydrat and 2 parts by volume of n-pi-olive alcohol.

   After cooling down and then standing for 2 days at about. 0 the 1,4-dihydrazino-phthalazine formed is filtered off with suction. The product is obtained in pure form by recrystallization from water, with the hot solution being filtered; F. = 189 with decomposition. The sulphate of F. = 236 (decomp.) Can be obtained directly from the raw product by taking it up in a little hot 2-n sulfuric acid.



  The piperidino-clilor-plithalazine used as an aliquot is easily obtained from di-elilorplitlialazine and piperidine by heating the components in a benzene solution. It drops to 132.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung des in der Schweizer Patentschrift Nr.262276 beschrie benen 1,4-Dihvdrazino-phthalazins, dadurch gekennzeichnet, dass man eine Verbindung der Formel EMI0001.0049 worin X und Y austauschfähige Substituenten und wenigstens einer davon eine Amino- gruppe bedeuten, mit 1Tydrazin umsetzt. UNTER-ANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet., dass man 1-Piperidino-4-chlor- phthalazin als Ausgangsstoff verwendet. PATENT CLAIM: Process for the preparation of the 1,4-Dihvdrazino-phthalazins described in Swiss Patent No. 262276, characterized in that a compound of the formula EMI0001.0049 where X and Y are exchangeable substituents and at least one of them is an amino group, with 1-tydrazine. SUB-CLAIM: Process according to patent claim, characterized in that 1-piperidino-4-chlorophthalazine is used as the starting material.
CH309830D 1952-01-18 1952-01-18 Process for producing a hydrazine compound. CH309830A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH307793T 1952-01-18
CH309830T 1952-01-18

Publications (1)

Publication Number Publication Date
CH309830A true CH309830A (en) 1955-09-15

Family

ID=25735326

Family Applications (1)

Application Number Title Priority Date Filing Date
CH309830D CH309830A (en) 1952-01-18 1952-01-18 Process for producing a hydrazine compound.

Country Status (1)

Country Link
CH (1) CH309830A (en)

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