CH279838A - Process for the preparation of a new aldehyde derivative. - Google Patents

Process for the preparation of a new aldehyde derivative.

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Publication number
CH279838A
CH279838A CH279838DA CH279838A CH 279838 A CH279838 A CH 279838A CH 279838D A CH279838D A CH 279838DA CH 279838 A CH279838 A CH 279838A
Authority
CH
Switzerland
Prior art keywords
works
aldehyde derivative
preparation
new
nicotinic acid
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellschaft Cilag
Original Assignee
Cilag Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cilag Ag filed Critical Cilag Ag
Publication of CH279838A publication Critical patent/CH279838A/en

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Description

  

  Verfahren zur Herstellung eines neuen     Aldehydderivates.       Gegenstand des Patentes ist ein Verfahren  zur Herstellung eines neuen     Aldehydderivates,     welches dadurch gekennzeichnet ist, dass man  auf     Nicotinsäure-oxymethylamid        Methylchlorid     einwirken lässt. Die Umsetzung wird vorzugs  weise bei erhöhter Temperatur und in einem  geschlossenen Gefäss, in An- oder Abwesen  heit von Lösungsmitteln, durchgeführt. Das  so erhaltene     Nl-Chlor-N1-methyl-nicotinsäure-          oxymethylamid    bildet farblose Kristalle, die  bei 160 bis 161  schmelzen und in Wasser  und Alkohol gut, in Äther und Aceton wenig  löslich sind.

   Die neue Verbindung soll als       Chemotherapeuticum    und als Zwischenpro  dukt Verwendung finden.         Beispiel:     43,7 g     Nicotinsäure-oxymethylamid    wer  den in 500     cm.3        Dioxan    aufgeschlämmt und  im     Autoklaven    mit 60 g     Methylehlorid    bei 100  bis 120  25 Stunden geschüttelt.  



  Nach dem Abkühlen wird die aus der Lö  sung auskristallisierte Masse     abgesogen    und  mit     Dioxan    und Äther gewaschen. Nach dem  Umfällen aus     Alkohol-Aceton    erhält man  45,1 g des bei 160 bis 161  schmelzenden     Nl-          Chlor-N1-methyl-nieotinsäure-oxymethylamids,     was einer Ausbeute von 78     1/a    der Theorie ent  spricht. Die neue Verbindung bildet farblose    Kristalle, die in Wasser und Alkohol gut, in  Äther, Aceton und     Dioxan    wenig löslich sind.



  Process for the preparation of a new aldehyde derivative. The subject of the patent is a process for the production of a new aldehyde derivative, which is characterized in that the nicotinic acid oxymethylamide methyl chloride is allowed to act. The reaction is preferably carried out at elevated temperature and in a closed vessel, in the presence or absence of solvents. The Nl-chloro-N1-methyl-nicotinic acid-oxymethylamide thus obtained forms colorless crystals which melt at 160 to 161 and are readily soluble in water and alcohol, but not very soluble in ether and acetone.

   The new compound is said to be used as a chemotherapeutic agent and as an intermediate product. Example: 43.7 g of nicotinic acid oxymethylamide who slurried in 500 cm.3 of dioxane and shaken in the autoclave with 60 g of methyl chloride for 100 to 120 hours.



  After cooling, the mass which has crystallized out of the solution is suctioned off and washed with dioxane and ether. After reprecipitation from alcohol-acetone, 45.1 g of Nl-chloro-N1-methyl-nieotinic acid-oxymethylamide, melting at 160 to 161, are obtained, which corresponds to a yield of 78 1 / a of theory. The new compound forms colorless crystals which are readily soluble in water and alcohol, but not very soluble in ether, acetone and dioxane.

Claims (1)

PATENTANSPRUCH: Verfahren mir Herstellung eines neuen Aldehydderiv ates, dadurch gekennzeichnet, dass man auf Nicotinsäure-oxymethyl.amid Methylchlorid einwirken lässt. Das so er haltene Nl-Chlor-N1-methyl-nicotinsäure-oxy- methylamid bildet farblose Kristalle, die bei 160 bis 161 schmelzen und in Wasser und Alkohol gut, in Äther und Aceton wenig lös lich sind. Die neue Verbindung soll als Chemotherapeuticum und als Zwischenprodukt Verwendung finden. UNTERANSPRÜCHE: 1. PATENT CLAIM: Process with the production of a new aldehyde derivative, characterized in that methyl chloride is allowed to act on nicotinic acid oxymethyl amide. The Nl-chloro-N1-methyl-nicotinic acid-oxymethylamide obtained in this way forms colorless crystals which melt at 160 to 161 and are well soluble in water and alcohol, but not very soluble in ether and acetone. The new compound is said to be used as a chemotherapeutic agent and as an intermediate. SUBCLAIMS: 1. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man in einem ge schlossenen Gefäss arbeitet.. 2. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man bei erhöhter Temperatur arbeitet. 3. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man in einem Lö sungsmittel arbeitet. 4. Verfahren nach Patentanspruch und Unteranspruch 3, dadurch gekennzeichnet, dass man als Lösungsmittel Dioxan verwendet. Process according to patent claim, characterized in that one works in a closed vessel .. 2. Process according to patent claim, characterized in that one works at an elevated temperature. 3. The method according to claim, characterized in that one works in a solvent Lö. 4. The method according to claim and dependent claim 3, characterized in that the solvent used is dioxane.
CH279838D 1949-07-12 1949-07-12 Process for the preparation of a new aldehyde derivative. CH279838A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH276857T 1949-07-12
CH279838T 1949-07-12

Publications (1)

Publication Number Publication Date
CH279838A true CH279838A (en) 1951-12-15

Family

ID=25731730

Family Applications (1)

Application Number Title Priority Date Filing Date
CH279838D CH279838A (en) 1949-07-12 1949-07-12 Process for the preparation of a new aldehyde derivative.

Country Status (1)

Country Link
CH (1) CH279838A (en)

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