CH279841A - Process for the preparation of a new aldehyde derivative. - Google Patents

Process for the preparation of a new aldehyde derivative.

Info

Publication number
CH279841A
CH279841A CH279841DA CH279841A CH 279841 A CH279841 A CH 279841A CH 279841D A CH279841D A CH 279841DA CH 279841 A CH279841 A CH 279841A
Authority
CH
Switzerland
Prior art keywords
acid
aldehyde derivative
preparation
oxymethylamide
new
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellschaft Cilag
Original Assignee
Cilag Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cilag Ag filed Critical Cilag Ag
Publication of CH279841A publication Critical patent/CH279841A/en

Links

Landscapes

  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung eines neuen     Aldehydderivates.       Gegenstand des Patentes ist ein Verfahren  zur Herstellung eines neuen     Aldehydderivates,     welches dadurch gekennzeichnet ist,     dass    man  auf     Nicotinsäure-oxymethylamid    Chloressig  säure einwirken     lässt.    Die Umsetzung wird  vorzugsweise bei erhöhter Temperatur, in     An-          oder    Abwesenheit von Lösungsmitteln, durch  geführt.

   Das so erhaltene     NI-Chlor-NI-carboxy-          raethyl-nieotinsäure-oxymethylamid    bildet ein  farbloses Pulver, das bei 1200 unter Zerset  zung schmilzt und in Wasser und Methanol  gut, in     Aeeton,    Äther und Essigester wenig  löslich ist. Die neue Verbindung soll als       Chemotherapeutieum    und als     Zwisehenpro-          dukt    Verwendung finden.  



  <I>Beispiel:</I>  <B>38 g</B>     Nieotinsäure-oxymethylamid    werden  mit<B>23,6 g</B> Chloressigsäure innig vermischt und       vorsiehtig    bis auf<B>1000</B> erhitzt. Die Mischung  schmilzt     innert   <B>30</B> Minuten zu einer klaren  Masse. Nun wird abgekühlt und die Schmelze  nach dem Pulverisieren in Äthanol gelöst und  mit     Aeeton    gefällt.

   Man erhält 41<B>g</B> des bei  1201' unter Zersetzung schmelzenden Nj-Chlor-         NI   <B>-</B>     earboxymethyl   <B>-</B>     nicotinsäure   <B>-</B>     oxymethyl-          amids.    Die neue Verbindung bildet ein farb  loses Pulver, das gut in Wasser und Methanol,  in Aceton, Äther und Essigester wenig lös  lich ist.



  Process for the preparation of a new aldehyde derivative. The subject of the patent is a process for the preparation of a new aldehyde derivative, which is characterized in that the nicotinic acid oxymethylamide chloroacetic acid is allowed to act. The reaction is preferably carried out at an elevated temperature, in the presence or absence of solvents.

   The NI-chloro-NI-carboxyraethyl-nieotinic acid-oxymethylamide thus obtained forms a colorless powder which melts with decomposition at 1200 and is readily soluble in water and methanol, and sparingly soluble in acetone, ether and ethyl acetate. The new compound is said to be used as a chemotherapeutic agent and as an byproduct.



  <I> Example: </I> <B> 38 g </B> of nieotinic acid oxymethylamide are intimately mixed with <B> 23.6 g </B> chloroacetic acid and carefully heated to <B> 1000 </B> . The mixture melts into a clear mass within <B> 30 </B> minutes. It is then cooled and, after pulverization, the melt is dissolved in ethanol and precipitated with aeeton.

   41 g of the Nj-chloro-NI <B> - </B> earboxymethyl <B> - </B> nicotinic acid <B> - </B> oxymethyl which melts at 1201 'with decomposition are obtained - amids. The new compound forms a colorless powder that is not very soluble in water and methanol, in acetone, ether and ethyl acetate.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines neuen Aldehydderivates, dadurch gekennzeichnet, dass man auf Nieotinsäure-oxymethylamid Chloressigsäure einwirken lässt. Das so er haltene N, <B>-</B> Chlor<B>-</B> N, <B>-</B> earboxymeth.yl <B>-</B> nieotin- säure-oxymethylamid bildet ein farbloses Pul ver, das bei 12011 unter Zersetzung schmilzt und in Wasser und Methanol gut, in Aceton, Äther und Essigester wenig löslich ist. PATENT CLAIM: Process for the production of a new aldehyde derivative, characterized in that chloroacetic acid is allowed to act on nieotinic acid-oxymethylamide. The N, <B> - </B> chlorine <B> - </B> N, <B> - </B> earboxymeth.yl <B> - </B> nieotinic acid oxymethylamide obtained in this way a colorless powder that melts with decomposition at 12011 and is well soluble in water and methanol, but not very soluble in acetone, ether and ethyl acetate. Die neue Verbindung soll als Chemotherapeutieum und als Zwischenprodukt Verwendung finden. <B>UNTERANSPRÜCHE:</B> <B>1.</B> Verfahren nach Patentansprueh, da durch gekennzeichnet, dass man bei erhöhter Temperatur arbeitet. 2. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man in Abwesen heit eines Lösunusmittels arbeitet. The new compound is said to be used as a chemotherapeutic agent and as an intermediate. <B> SUBClaims: </B> <B> 1. </B> Method according to patent claim, characterized in that one works at an elevated temperature. 2. The method according to claim, characterized in that one works in the absence of a solvent unit.
CH279841D 1949-07-12 1949-07-12 Process for the preparation of a new aldehyde derivative. CH279841A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH276857T 1949-07-12
CH279841T 1949-07-12

Publications (1)

Publication Number Publication Date
CH279841A true CH279841A (en) 1951-12-15

Family

ID=25731732

Family Applications (1)

Application Number Title Priority Date Filing Date
CH279841D CH279841A (en) 1949-07-12 1949-07-12 Process for the preparation of a new aldehyde derivative.

Country Status (1)

Country Link
CH (1) CH279841A (en)

Similar Documents

Publication Publication Date Title
CH279841A (en) Process for the preparation of a new aldehyde derivative.
DE916980C (en) Process for the production of higher molecular weight products from compounds containing hydroxyl and cyano groups on different carbon atoms
CH279842A (en) Process for the preparation of a new aldehyde derivative.
DE825684C (en) Process for the production of carboxylic acid esters
DE878861C (en) Process for the production of polyvinyl formals
DE940680C (en) Process for the production of polyvinyl esters from polyvinyl compounds containing hydroxyl groups and diketene
DE916468C (en) Process for the production of synthetic resins
CH279838A (en) Process for the preparation of a new aldehyde derivative.
DE749146C (en) Process for the production of ªŠ-oxycarboxylic acids
DE889693C (en) Process for the production of condensation products
DE604920C (en) Process for the preparation of cyclic 1,2-aminoketones
DE1018052B (en) Process for the preparation of antimony complex compounds of ª ‡, ª ‡ &#39;-Dimercaptosuccinic acid
DE1280849B (en) Process for the production of curcumin from vanillin and acetylacetone
CH312528A (en) Process for the preparation of a new pyridine derivative.
CH279840A (en) Process for the preparation of a new aldehyde derivative.
CH284799A (en) Process for the preparation of 3 (a) -acetoxy-11-keto-12,21-dibromo-24,24-diphenyl-20:22, 23:24-choladiene.
DE1143514B (en) Process for the production of Oestriol-16, 17-dihemisuccinate or its water-soluble salts
CH362092A (en) Process for the preparation of dimethylaminopropyloxybenzenes
DE1163317B (en) Process for the preparation of 4,4-bis-hydroperoxy-cyclohexadien- (2,5) -one- (1)
DE1006415B (en) Process for the preparation of p-nitrobenzaldoxime
CH380123A (en) Process for the preparation of estriol derivatives
DE1148560B (en) Process for the preparation of amoebicidally active esters of p-hydroxy-N-dichloroacet-N-methylanilide
CH292797A (en) Process for the preparation of 3 (a), 21-diacetoxy-11-keto-12-bromo-24,24-diphenyl-20: 22,23: 24-choladiene.
CH276857A (en) Process for the preparation of a new aldehyde derivative.
DE1270571B (en) Process for the production of ephedrine phosphoric acid ester-betaines and their salts