DE1018052B - Process for the preparation of antimony complex compounds of ª ‡, ª ‡ '-Dimercaptosuccinic acid - Google Patents
Process for the preparation of antimony complex compounds of ª ‡, ª ‡ '-Dimercaptosuccinic acidInfo
- Publication number
- DE1018052B DE1018052B DEF7794A DEF0007794A DE1018052B DE 1018052 B DE1018052 B DE 1018052B DE F7794 A DEF7794 A DE F7794A DE F0007794 A DEF0007794 A DE F0007794A DE 1018052 B DE1018052 B DE 1018052B
- Authority
- DE
- Germany
- Prior art keywords
- antimony
- dimercaptosuccinic acid
- preparation
- complex compounds
- antimony complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/90—Antimony compounds
- C07F9/902—Compounds without antimony-carbon linkages
Description
Verfahren zur Herstellung von Antimonkomplexverbindungen der a,a'-Dimercaptobernsteinsäure Die Erfindung betrifft ein Verfahren zur Herstellung von Antimonkomplexverbindungen der a, ä -Dimercaptobernsteinsäure.A process for producing antimony complex compounds of a a'-dimercaptosuccinic acid, The invention relates to a process for the production of antimony complex compound of a, a -Dimercaptobernsteinsäure.
Das Verfahren der Erfindung besteht darin, daß man freie a, ä -Dimercaptobernsteinsäure in einem organischen Lösungsmittel mit einer Antimonverbindung zur Reaktion bringt. Die bei dieser Reaktion entstandene Antimonkomplexverbindung kann aus dem Lösungsmittel durch Verdampfen des Lösungsmittels oder durch Fällung mit geeigneten organischen Lösungsmitteln oder ähnlichen Fällungsmitteln gewonnen werden.The method of the invention consists in that one free α, α -dimercaptosuccinic acid reacts with an antimony compound in an organic solvent. The antimony complex compound formed in this reaction can be extracted from the solvent by evaporation of the solvent or by precipitation with suitable organic Solvents or similar precipitants are obtained.
Die erfindungsgemäß hergestellten Antimonverbindungen zeichnen sich bei ihrer pharmazeutischen Anwendung durch ihre herabgesetzte Toxizität im Vergleich zu der Toxizität anderer Verbindungen des Antimons unter sonst gleichen Umständen aus.The antimony compounds prepared according to the invention are notable in their pharmaceutical application by their reduced toxicity in comparison on the toxicity of other compounds of antimony under otherwise identical circumstances the end.
Die erfindungsgemäß hergestellten Verbindungen entsprechen der allgemeinen Formel Die dritte Valenz des Sb-Atoms kann an ein Atom oder eine Atomgruppierung, wie -Cl, - (CO, C H3) oder -O H, gebunden sein.The compounds prepared according to the invention correspond to the general formula The third valence of the Sb atom can be attached to an atom or a grouping of atoms, such as -Cl, - (CO, C H3) or -OH.
Beispiel 1 Gewichtsteil Antimonacetat der Formel (CH, C O O) 3 Sb wird in eine heiße Lösung von einem Gewichtsteil a, ä -Dimercaptobernsteinsäure in 25 Teilen Methanol eingerührt. Die Lösung wird filtriert und mit Natriumacetat gesättigt. Es bildet sich ein weißer Niederschlag, der abfiltriert und im Vakuum getrokknet wird. Das Produkt entspricht wahrscheinlich folgender Formel: Die Verbindung ist sehr leicht löslich in Wasser und gibt eine farblose, klare Lösung mit einem pn-Wert von 4 bis 5.Example 1 part by weight of antimony acetate of formula (CH, COO) 3 Sb is stirred into a hot solution of one part by weight of a, a -Dimercaptobernsteinsäure in 25 parts of methanol. The solution is filtered and saturated with sodium acetate. A white precipitate forms, which is filtered off and dried in vacuo. The product probably corresponds to the following formula: The compound is very easily soluble in water and gives a colorless, clear solution with a pn value of 4 to 5.
An Stelle von Antimonacetat kann in diesem Beispiel auch Antimonhydroxyd der Formel Sb (0H)3 verwendet werden.Instead of antimony acetate, antimony hydroxide can also be used in this example of the formula Sb (0H) 3 can be used.
Die als Ausgangsverbindung verwendete a, ä -Dimercaptobernsteinsäure ist aus Journal of the Chemical Society, 1949, S. 3112, bekannt.The α, α-dimercaptosuccinic acid used as the starting compound is known from Journal of the Chemical Society, 1949, p. 3112.
Die erfindungsgemäß hergestellten Verbindungen können für therapeutische Zwecke, insbesondere zur Bekämpfung von Infektionskrankheiten Anwendung finden, wobei ihr wirksamer Bestandteil Sb ist, das im Zustand herabgesetzter Giftigkeit im Molekül vorhanden ist. .The compounds prepared according to the invention can be used for therapeutic Purposes, in particular to combat infectious diseases, its active ingredient being Sb, that in the state of decreased toxicity is present in the molecule. .
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA1018052X | 1951-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1018052B true DE1018052B (en) | 1957-10-24 |
Family
ID=4173418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEF7794A Pending DE1018052B (en) | 1951-11-15 | 1951-12-03 | Process for the preparation of antimony complex compounds of ª ‡, ª ‡ '-Dimercaptosuccinic acid |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE1018052B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1132126B (en) * | 1959-07-31 | 1962-06-28 | Rhone Poulenc Sa | Process for the production of antimony derivatives |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE949055C (en) * | 1951-09-06 | 1956-09-13 | Rheinpreussen Ag | Process for the production of heavy metal complex compounds of ª ‡, ª ‡ -Dimercaptosuccinic acid |
-
1951
- 1951-12-03 DE DEF7794A patent/DE1018052B/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE949055C (en) * | 1951-09-06 | 1956-09-13 | Rheinpreussen Ag | Process for the production of heavy metal complex compounds of ª ‡, ª ‡ -Dimercaptosuccinic acid |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1132126B (en) * | 1959-07-31 | 1962-06-28 | Rhone Poulenc Sa | Process for the production of antimony derivatives |
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