CH268086A - Process for the preparation of an acylated aliphatic aminocarboxamide. - Google Patents

Process for the preparation of an acylated aliphatic aminocarboxamide.

Info

Publication number
CH268086A
CH268086A CH268086DA CH268086A CH 268086 A CH268086 A CH 268086A CH 268086D A CH268086D A CH 268086DA CH 268086 A CH268086 A CH 268086A
Authority
CH
Switzerland
Prior art keywords
aminocarboxamide
preparation
butyric acid
acylated aliphatic
dimethylamide
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH268086A publication Critical patent/CH268086A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  <B>verfahren zur Darstellung eines</B>     acylierten        aliphatiseben        Aminocarbonsäureamides.       Gegenstand vorliegenden Patentes ist ein  Verfahren zur Darstellung eines     acylierten          aliphatischen        Aminocarbonsäureamides.    Das  Verfahren ist dadurch gekennzeichnet, dass  man N -     Acetyl    - a -     allylamino    -     buttersäure-          dimethylamid    reduziert.  



  Die entstandene neue Verbindung, das     N-          Acetyl-a-        (n-propyl-amino)-buttersäure-dime-          thylamid    der Formel  
EMI0001.0015     
    bildet eine farblose Flüssigkeit vom Siede  punkt 128 bis 130  unter 0,2 mm Druck. Sie  soll therapeutische Verwendung finden.    <I>Beispiel:</I>    21,2 Teile     N-Acetyl-a-allylamino-butter-          säure-dimethylamid    werden in 100 Teilen       Wasser    gelöst, dazu 2,5 Teile     Raney-Nickel     gegeben und das Gemisch in Gegenwart von  Wasserstoff so lange bei     Zimmertemperatur     geschüttelt, bis kein Wasserstoff mehr auf  genommen wird.

   Dann wird vom Katalysator       abfiltriert,    das Filtrat mit     Kaliumhydroxyd       gesättigt und das abgeschiedene öl in Benzol  aufgenommen. Nach dem Trocknen der     ben-          zolischen    Lösung über     Kaliumhydroxyd        wird     vom Lösungsmittel befreit und das     N-Acetyl-          a-(n-propylamino)        -buttersäure-dimethylamid     im Hochvakuum rektifiziert. Die farblose, in  Wasser leicht lösliche Flüssigkeit siedet unter  0,2 mm Druck bei 128 bis 130   Statt bei Zimmertemperatur, kann die Hy  drierung auch bei 50 bis 60  ausgeführt wer  den.



  <B> Process for the preparation of an <B> acylated aliphatic aminocarboxamide. The present patent relates to a process for the preparation of an acylated aliphatic aminocarboxamide. The process is characterized in that N - acetyl - a - allylamino - butyric acid dimethylamide is reduced.



  The resulting new compound, the N-acetyl-a- (n-propyl-amino) -butyric acid dimethylamide of the formula
EMI0001.0015
    forms a colorless liquid with a boiling point of 128 to 130 under 0.2 mm pressure. It should find therapeutic use. <I> Example: </I> 21.2 parts of N-acetyl-α-allylamino-butyric acid-dimethylamide are dissolved in 100 parts of water, 2.5 parts of Raney nickel are added and the mixture is like this in the presence of hydrogen Long shaken at room temperature until no more hydrogen is absorbed.

   The catalyst is then filtered off, the filtrate is saturated with potassium hydroxide and the separated oil is taken up in benzene. After the benzene solution has been dried over potassium hydroxide, the solvent is removed and the N-acetyl-a- (n-propylamino) -butyric acid dimethylamide is rectified in a high vacuum. The colorless liquid, which is easily soluble in water, boils under 0.2 mm pressure at 128 to 130 degrees.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines acylierten aliphatischen Aminocarbonsäureamides, da durch gekennzeichnet, dass man N-Aeetyl-a- allylamino - Buttersäure - dimethylamid redu ziert. Die entstandene neue Verbindung, das N- Acetyl - a - (n - propylamino) - Buttersäure - di- methylamid der Formel EMI0001.0041 bildet eine farblose Flüssigkeit vom Siede punkt 128 bis 130 unter 0,2 mm Druck. PATENT CLAIM: Process for the preparation of an acylated aliphatic aminocarboxamide, characterized in that N-ethyl-a-allylamino - butyric acid - dimethylamide is reduced. The resulting new compound, the N-acetyl - a - (n - propylamino) - butyric acid - dimethylamide of the formula EMI0001.0041 forms a colorless liquid with a boiling point of 128 to 130 under 0.2 mm pressure.
CH268086D 1946-07-01 1946-07-01 Process for the preparation of an acylated aliphatic aminocarboxamide. CH268086A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH268086T 1946-07-01
CH254949T 1946-07-01

Publications (1)

Publication Number Publication Date
CH268086A true CH268086A (en) 1950-04-30

Family

ID=25729881

Family Applications (1)

Application Number Title Priority Date Filing Date
CH268086D CH268086A (en) 1946-07-01 1946-07-01 Process for the preparation of an acylated aliphatic aminocarboxamide.

Country Status (1)

Country Link
CH (1) CH268086A (en)

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