CH268087A - Process for the preparation of an acylated aliphatic aminocarboxamide. - Google Patents

Process for the preparation of an acylated aliphatic aminocarboxamide.

Info

Publication number
CH268087A
CH268087A CH268087DA CH268087A CH 268087 A CH268087 A CH 268087A CH 268087D A CH268087D A CH 268087DA CH 268087 A CH268087 A CH 268087A
Authority
CH
Switzerland
Prior art keywords
aminocarboxamide
preparation
propionyl
acylated aliphatic
dimethylamide
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH268087A publication Critical patent/CH268087A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Darstellung eines     acylierten        aliphatischen        Aminocarbonsäureamides.       Gegenstand vorliegenden Patentes ist ein  Verfahren zur Darstellung eines     acylierten          aliphatischen        Aminocarbonsäureamides,    da  durch gekennzeichnet, dass man     N-Propionyl-          a    -     allylamino    -     isovaleriansäure    -     dimethylamid     reduziert.

   Die entstandene neue Verbindung,  das     N-Propionyl-a-        (n-propylamino)        -isovale-          riansäure-dimethylamid    der Formel  
EMI0001.0016     
    bildet eine farblose Flüssigkeit vom Siede  punkt 113-115  unter 0,1 mm Druck. Sie  soll therapeutische Verwendung finden.    <I>Beispiel:</I>    24 Teile N -     Propionyl    -     allylamino    -     iso        -          valeriansäure-dimethylamid    werden in 100 Tei  len     50Ohigem    Alkohol gelöst, mit 2,5 Teilen       Raney-Nickel    versetzt und mit Wasserstoff  bei Zimmertemperatur geschüttelt.

   Sobald die  berechnete Menge Wasserstoff aufgenommen  ist, wird vom Katalysator     abfiltriert,    der Al  kohol     abdestilliert    und die     wässrige    Lösung    mit     Kaliumhydroxyd        gesättigt.    Das abge  schiedene öl wird in     Xylol    aufgenommen und  getrocknet. Nach     Abdestillieren    des Lösungs  mittels wird das     N-Propionyl-a-        (n-propyl-          amino)    -     isovaleriansäure    -     dimethylamid    im  Hochvakuum destilliert.

   Es siedet unter  0,1 mm bei 113 bis 115     11.     



  Statt bei Zimmertemperatur, kann die Hy  drierung auch bei 50 bis 60  ausgeführt wer  den.



  Process for the preparation of an acylated aliphatic aminocarboxamide. The subject of the present patent is a process for the preparation of an acylated aliphatic aminocarboxamide, characterized in that N-propionyl-α-allylamino-isovaleric acid-dimethylamide is reduced.

   The resulting new compound, the N-propionyl-a- (n-propylamino) -isovaleric acid dimethylamide of the formula
EMI0001.0016
    forms a colorless liquid with a boiling point of 113-115 under 0.1 mm pressure. It should find therapeutic use. <I> Example: </I> 24 parts of N - propionyl - allylamino - iso - valeric acid dimethylamide are dissolved in 100 parts of 50% alcohol, 2.5 parts of Raney nickel are added and the mixture is shaken with hydrogen at room temperature.

   As soon as the calculated amount of hydrogen has been absorbed, the catalyst is filtered off, the alcohol is distilled off and the aqueous solution is saturated with potassium hydroxide. The separated oil is taken up in xylene and dried. After the solvent has been distilled off, the N-propionyl-a- (n-propyl-amino) -isovaleric acid-dimethylamide is distilled in a high vacuum.

   It boils below 0.1 mm at 113 to 115 11.



  Instead of at room temperature, the hydrogenation can also be carried out at 50 to 60.

Claims (1)

PATENTANSPRUCH Verfahren zur Darstellung eines acylierten aliphatischen Aminocarbonsäureamides, da durch gekennzeichnet, dass man N-Propionyl- a-allylamino@- isovaleriansäure - dimethylamid reduziert. Die entstandene neue Verbindung, das N - Propionyl - a - (n - propylamino) - iso- valeriansäure-dimethylamid der Formel EMI0001.0048 bildet eine farblose Flüssigkeit vom Siede punkt 113 bis 115 unter 0,1 mm Druck. PATENT CLAIM Process for the preparation of an acylated aliphatic aminocarboxamide, characterized in that N-propionyl-a-allylamino @ - isovaleric acid - dimethylamide is reduced. The resulting new compound, the N - propionyl - a - (n - propylamino) - isovaleric acid dimethylamide of the formula EMI0001.0048 forms a colorless liquid with a boiling point of 113 to 115 under 0.1 mm pressure.
CH268087D 1946-07-01 1946-07-01 Process for the preparation of an acylated aliphatic aminocarboxamide. CH268087A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH268087T 1946-07-01
CH254949T 1946-07-01

Publications (1)

Publication Number Publication Date
CH268087A true CH268087A (en) 1950-04-30

Family

ID=25729882

Family Applications (1)

Application Number Title Priority Date Filing Date
CH268087D CH268087A (en) 1946-07-01 1946-07-01 Process for the preparation of an acylated aliphatic aminocarboxamide.

Country Status (1)

Country Link
CH (1) CH268087A (en)

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