CH269982A - Process for the preparation of a derivative of 3,5-dioxo-pyrazolidine. - Google Patents

Process for the preparation of a derivative of 3,5-dioxo-pyrazolidine.

Info

Publication number
CH269982A
CH269982A CH269982DA CH269982A CH 269982 A CH269982 A CH 269982A CH 269982D A CH269982D A CH 269982DA CH 269982 A CH269982 A CH 269982A
Authority
CH
Switzerland
Prior art keywords
dioxo
pyrazolidine
derivative
preparation
diphenyl
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH269982A publication Critical patent/CH269982A/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  <B>Verfahren zur Herstellung eines Derivates des</B>     3,5-Dioxo-pyrazolidins.       Gegenstand vorliegenden Patentes ist ein  Verfahren zur Herstellung eines Derivates des       3,5-Dioxo-pyrazolidins.    Das Verfahren ist da  durch gekennzeichnet, dass man     1,2-Diphenyl-          3,5-dioxo-pyrazolidin,        Benzaldehyd    und ein  hydrierendes Mittel aufeinander einwirken  lässt.  



  Die erhaltene neue Verbindung, das     1,2-Di-          phenyl-3,5-dioxo-4-benzyl-pyrazolidin,    zeigt  einen Schmelzpunkt von 136-138 . Sie soll  therapeutische Verwendung finden.  



  <I>Beispiel:</I>  Eine Lösung von 160 Teilen     1,2-Diphenyl-          3,5-dioxo-pyrazolidin    und 120 Teilen Benz  aldehyd in 500     Volumteilen    Alkohol wird  unter 20 Atmosphären     @Vasserst@offdruck    bei  Gegenwart von     Raney-Nickel    auf 100  erhitzt,  bis die Wasserstoffaufnahme langsam und die  Lösung farblos wird. Aus der heiss filtrierten  Lösung kristallisiert das     1,2-Diphenyl-3,5-          dioxo-4-benzyl-pyrazolidin    vom Schmelzpunkt  136 bis 138<B>0</B> aus.



  <B> Process for the preparation of a derivative of </B> 3,5-dioxo-pyrazolidine. The present patent relates to a process for the preparation of a derivative of 3,5-dioxo-pyrazolidine. The process is characterized in that 1,2-diphenyl-3,5-dioxo-pyrazolidine, benzaldehyde and a hydrogenating agent are allowed to act on one another.



  The new compound obtained, 1,2-diphenyl-3,5-dioxo-4-benzylpyrazolidine, has a melting point of 136-138. It should find therapeutic use.



  <I> Example: </I> A solution of 160 parts of 1,2-diphenyl-3,5-dioxo-pyrazolidine and 120 parts of benzaldehyde in 500 parts by volume of alcohol is under 20 atmospheres @ Vasserst @ off pressure in the presence of Raney nickel heated to 100 until the hydrogen uptake slowly and the solution becomes colorless. The 1,2-diphenyl-3,5-dioxo-4-benzyl-pyrazolidine with a melting point of 136 to 138 crystallizes out of the hot-filtered solution.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines Derivates des 3,5-Dioxopyrazolidins, dadurch gekenn zeichnet, dass man 1,2-Diphenyl-3,5-dioxo-pyr- azolidin, Benzaldehyd und ein hydrierendes Mittel aufeinander einwirken lässt. Die erhaltene neue Verbindung, das 1,2-Di- phenyl-3,5-dioxo-4-benzyl-pyrazolidin, zeigt einen Schmelzpunkt von 136-138 . UN TERANSPRL CHE 1. Verfahren nach Patentanspruch, da durch gekennzeichnet., dass man als hydrieren des Mittel Wasserstoff in Gegenwart. eines HydrierungskatalyBators verwendet. 2. PATENT CLAIM: Process for the preparation of a derivative of 3,5-dioxopyrazolidine, characterized in that 1,2-diphenyl-3,5-dioxo-pyrazolidine, benzaldehyde and a hydrogenating agent are allowed to act on one another. The new compound obtained, 1,2-diphenyl-3,5-dioxo-4-benzylpyrazolidine, has a melting point of 136-138. UN TERANSPRL CHE 1. Process according to claim, characterized in that the hydrogenation of the agent is hydrogen in the presence. a hydrogenation catalyst is used. 2. Verfahren nach Patentanspruch und Unteranspruch 1, dadurch gekennzeichnet, dass man das 1,2-Diphenyl-3,5-dioxo-pyrazol- idin, den Benzaldehyd und den Wasserstoff <B>01</B> eichzeitig aufeinander einwirken lässt. Process according to claim and dependent claim 1, characterized in that the 1,2-diphenyl-3,5-dioxo-pyrazolidine, the benzaldehyde and the hydrogen 01 are allowed to act on one another at the same time.
CH269982D 1948-03-22 1948-03-22 Process for the preparation of a derivative of 3,5-dioxo-pyrazolidine. CH269982A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH269982T 1948-03-22
CH266237T 1948-03-22

Publications (1)

Publication Number Publication Date
CH269982A true CH269982A (en) 1950-07-31

Family

ID=25730856

Family Applications (1)

Application Number Title Priority Date Filing Date
CH269982D CH269982A (en) 1948-03-22 1948-03-22 Process for the preparation of a derivative of 3,5-dioxo-pyrazolidine.

Country Status (1)

Country Link
CH (1) CH269982A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909465A (en) * 1952-09-18 1959-10-20 Knoll Ag 1, 4-diphenyl-3, 5-diketo pyrazolidine compounds and compositions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909465A (en) * 1952-09-18 1959-10-20 Knoll Ag 1, 4-diphenyl-3, 5-diketo pyrazolidine compounds and compositions

Similar Documents

Publication Publication Date Title
CH269982A (en) Process for the preparation of a derivative of 3,5-dioxo-pyrazolidine.
CH269981A (en) Process for the preparation of a derivative of 3,5-dioxo-pyrazolidine.
CH309770A (en) Process for the preparation of a monosubstituted hydrazine.
AT148148B (en) Process for the production of condensation products.
CH269980A (en) Process for the preparation of a derivative of 3,5-dioxo-pyrazolidine.
DE389422C (en) Process for the production of a disinfectant
DE615399C (en) Process for the preparation of alkyl acetamides
DE488348C (en) Process for the preparation of d, l-nerolidol
AT104405B (en) Process for the production of a means for protecting and killing insects.
CH268087A (en) Process for the preparation of an acylated aliphatic aminocarboxamide.
AT226858B (en) Process for the production of a magnesia-containing resin soap
AT233178B (en) Process for the preparation of the new 3β-hydroxy-6-methylpregn-5-en-20-one and its 3β-acyloxy derivatives
DE395703C (en) Process for the production of soft masses from cellulose esters
CH268088A (en) Process for the preparation of an acylated aliphatic aminocarboxamide.
CH235907A (en) Process for the preparation of a di (p-cyclohexanolyl) diethyl ethane.
CH224899A (en) Process for the preparation of 4-oxy-1-dimethylaminoacetoxy-2-methyl-naphthalene-chloromethylate.
CH321805A (en) Process for the production of a washing and cleaning agent emulsion
CH220961A (en) Process for the preparation of 2,4-dioxo-3-n-propyl-3-isobutylpyrrolidine.
CH219928A (en) Process for the preparation of 2,6-dimethyl-undecanol- (10).
CH254949A (en) Process for the preparation of an acylated aliphatic aminocarboxamide.
CH263483A (en) Process for the preparation of a new oxyhydrophenanthrene derivative.
CH124262A (en) Process for the preparation of a hydrogenation product of anthraquinone.
CH223210A (en) Process for the preparation of phenyl-cyclohexyl-acetic acid.
CH308694A (en) Process for the preparation of the chlorohydrate of dimethylaminoethyl ester of 4-n-butylamino-2-oxy-benzoic acid.
CH300833A (en) Process for the preparation of an N-acyl derivative of iminodibenzyl.