CH268088A - Process for the preparation of an acylated aliphatic aminocarboxamide. - Google Patents

Process for the preparation of an acylated aliphatic aminocarboxamide.

Info

Publication number
CH268088A
CH268088A CH268088DA CH268088A CH 268088 A CH268088 A CH 268088A CH 268088D A CH268088D A CH 268088DA CH 268088 A CH268088 A CH 268088A
Authority
CH
Switzerland
Prior art keywords
aminocarboxamide
preparation
propionyl
valeric acid
aliphatic
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH268088A publication Critical patent/CH268088A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  <B>Verfahren zur Darstellung eines</B>     aeylierten        aliphatischen        Aminocarbonsäureamides.       Gegenstand vorliegenden Patentes ist ein  Verfahren zur Darstellung eines     acylierten          aliphatischen        Aminocarbonsäureamides.    Das  Verfahren ist dadurch gekennzeichnet, dass  man     N-Propionyl-a-allylamino-n-valerian-          säure-dimethylamid        reduziert.       Die entstandene neue Verbindung, das     N-          Propionyl-a-        (n-propylamino)

      -     n-valeriansäure-          dimethylamid    der Formel  
EMI0001.0015     
    bildet eine farblose Flüssigkeit vom Siede  punkt 141-142  unter 0,25 mm Druck. Sie  soll therapeutische Verwendung finden.  



  <I>Beispiel,:</I>  24,0 Teile     N-Propionyl-a-allylamino-n-          valeriansäure-dimethylamid    werden in 100 Tei  len Wasser gelöst, dazu 2,5 Teile     Raney-Nickel     gegeben und das Gemisch in Gegenwart von  Wasserstoff so lange bei Zimmertemperatur  geschüttelt, bis kein Wasserstoff mehr auf  genommen wird.

   Dann wird vom Katalysator       abfiltriert,    das Filtrat mit     Kaliumhydroxyd       gesättigt und das abgeschiedene Öl in Benzol       aufgenommen.    Nach dem Trocknen der     ben-          zolischen    Lösung über     Kaliumhydroxyd    wird  vom Lösungsmittel befreit und das     N-Pro-          pionyl-a-        (n-propylamino)        -n-valeriansäure-di-          methylamid    im     Hoehvakuum    rektifiziert. Die  farblose, in Wasser leicht lösliche Flüssigkeit  siedet unter 0,25 mm Druck bei 141 bis 142 .  



  Statt bei Zimmertemperatur, kann die Hy  drierung auch bei 50 bis 60  ausgeführt wer  den.



  <B> Process for the preparation of </B> aeylated aliphatic aminocarboxamide. The present patent relates to a process for the preparation of an acylated aliphatic aminocarboxamide. The process is characterized in that N-propionyl-a-allylamino-n-valeric acid dimethylamide is reduced. The resulting new compound, the N-propionyl-a- (n-propylamino)

      - n-valeric acid dimethylamide of the formula
EMI0001.0015
    forms a colorless liquid with a boiling point 141-142 under 0.25 mm pressure. It should find therapeutic use.



  <I> Example: </I> 24.0 parts of N-propionyl-a-allylamino-n-valeric acid dimethylamide are dissolved in 100 parts of water, 2.5 parts of Raney nickel are added and the mixture is in the presence of Shake hydrogen at room temperature until no more hydrogen is absorbed.

   The catalyst is then filtered off, the filtrate is saturated with potassium hydroxide and the separated oil is taken up in benzene. After the benzene solution has been dried over potassium hydroxide, the solvent is removed and the N-propionyl-a- (n-propylamino) -n-valeric acid dimethylamide is rectified in a high vacuum. The colorless liquid, easily soluble in water, boils at 141 to 142 under 0.25 mm pressure.



  The hydrogenation can also be carried out at 50 to 60 instead of at room temperature.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines acylierten aliphatischen Aminocarbonsäureamides, da durch gekennzeichnet, dass man N-Propionyl- a - allylamino-n-valeriansäure - dimethylamid reduziert. Die entstandene neue Verbindung, das N-Pr opionyl-a- (n-propylamino) -n-valerian- säure-dimethylamid der Formel EMI0001.0043 bildet eine farblose Flüssigkeit vom Siede punkt 141-142 unter 0,25 mm Druck. PATENT CLAIM: Process for the preparation of an acylated aliphatic aminocarboxamide, characterized in that N-propionyl- a - allylamino-n-valeric acid - dimethylamide is reduced. The resulting new compound, the N-propionyl-a- (n-propylamino) -n-valeric acid dimethylamide of the formula EMI0001.0043 forms a colorless liquid with a boiling point 141-142 under 0.25 mm pressure.
CH268088D 1946-07-01 1946-07-01 Process for the preparation of an acylated aliphatic aminocarboxamide. CH268088A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH268088T 1946-07-01
CH254949T 1946-07-01

Publications (1)

Publication Number Publication Date
CH268088A true CH268088A (en) 1950-04-30

Family

ID=25729883

Family Applications (1)

Application Number Title Priority Date Filing Date
CH268088D CH268088A (en) 1946-07-01 1946-07-01 Process for the preparation of an acylated aliphatic aminocarboxamide.

Country Status (1)

Country Link
CH (1) CH268088A (en)

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