CH243014A - Process for the preparation of an acylated, aliphatic aminocarboxamide. - Google Patents

Process for the preparation of an acylated, aliphatic aminocarboxamide.

Info

Publication number
CH243014A
CH243014A CH243014DA CH243014A CH 243014 A CH243014 A CH 243014A CH 243014D A CH243014D A CH 243014DA CH 243014 A CH243014 A CH 243014A
Authority
CH
Switzerland
Prior art keywords
acylated
preparation
aliphatic
aminocarboxamide
valeric acid
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH243014A publication Critical patent/CH243014A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Darstellung eines     acyllerten,        aliphatisehen        Aminocarbonsäureamids.            Gegenstand    des     vorliegenden    Zusatzpaten  tes ist ein Verfahren zur Darstellung eines       acylierten,        aliphatischen        Aminocarbonsäure-          amids.    Das Verfahren ist dadurch gekenn  zeichnet,

   dass ein     a-Halogen-n-valeriansäure-          dimethylamid    mit     Äthylamin    umgesetzt und  das Reaktionsprodukt mit einer das Radikal  der     n-Buttersäure    abgebenden Verbindung       acyliert        wird.     



  Das     N-(n-Butyroyl)-a-äthylamino-n-va-          leriansäuredimethylamid    der Formel  
EMI0001.0018     
         bildet    eine farblose     Flüssigkeit    vom Siede  punkt 119 bis 120  unter 0,02 mm.  



  Die neue Verbindung soll therapeutische  Verwendung finden.  



  <I>Beispiel:</I>  34,4 Teile     a-Äthylamino-n-valeriansäure-          dimethylamid,        Kp12    110 bis 111  (dargestellt    aus a - Brom - n -     valeriausäuredimethylamid     durch Erhitzen mit     Äthylamin)    werden in  200 Teilen Äther gelöst und unter Rühren  und Kühlen 10,6 Teile     n-Buttersäurechlorid          zugetropft.    Nach zweistündigem Rühren wird  vom     a-Äthylamino-n-valeriansäuredimethyl-          amid-chlorhydrat        abfiltriert    und die äthe  rische Lösung mit gesättigter Kalilauge ge  schüttelt.

   Nach dem     Abdestillieren    des Lö  sungsmittels     wird    das Reaktionsprodukt im  Hochvakuum rektifiziert. Die neue Verbin  dung siedet bei 119 bis 120  unter 0,02 mm  und ist löslich in Wasser und organischen       Lösungsmitteln.  



  Process for the preparation of an acrylated, aliphatic aminocarboxamide. The present additional patent is a process for the preparation of an acylated, aliphatic aminocarboxylic acid amide. The procedure is characterized by

   that an α-halo-n-valeric acid dimethylamide is reacted with ethylamine and the reaction product is acylated with a compound which releases the radical of n-butyric acid.



  The N- (n-butyroyl) -a-ethylamino-n-valeric acid dimethylamide of the formula
EMI0001.0018
         forms a colorless liquid with a boiling point of 119 to 120 below 0.02 mm.



  The new compound should find therapeutic use.



  <I> Example: </I> 34.4 parts of a-ethylamino-n-valeric acid dimethylamide, Kp12 110 to 111 (prepared from a - bromine - n - valeric acid dimethylamide by heating with ethylamine) are dissolved in 200 parts of ether and taken under 10.6 parts of n-butyric acid chloride were added dropwise to stirring and cooling. After two hours of stirring, the a-ethylamino-n-valeric acid dimethyl amide chlorohydrate is filtered off and the ethereal solution is shaken with saturated potassium hydroxide solution.

   After the solvent has been distilled off, the reaction product is rectified in a high vacuum. The new compound boils at 119 to 120 below 0.02 mm and is soluble in water and organic solvents.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines acylier- ten, aliphatischen Aminocarbonsäureamids, dadurch gekennzeichnet, dass ein a-Halogen- n-valeriansäuredimethylamid mit Äthylamin umgesetzt und das Reaktionsprodukt mit einer das Radikal der n-Buttersäure abgeben den Verbindung acyliert wird. Claim: Process for the preparation of an acylated, aliphatic aminocarboxamide, characterized in that an α-halo-n-valeric acid dimethylamide is reacted with ethylamine and the reaction product is acylated with a compound that releases the radical of n-butyric acid. Das N-(n-Butyroyl)-a-äthylämino-n-vale- riansäuredimethylamid der Formel EMI0002.0003 bildet eine farblose Flüssigkeit vom Siede punkt 119 bis 120 unter 0,02 mm. Die neue Verbindung soll therapeutische Verwendung finden. The N- (n-butyroyl) -a-ethylamino-n-valeric acid dimethylamide of the formula EMI0002.0003 forms a colorless liquid with a boiling point of 119 to 120 below 0.02 mm. The new compound should find therapeutic use.
CH243014D 1942-12-18 1942-12-18 Process for the preparation of an acylated, aliphatic aminocarboxamide. CH243014A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH243014T 1942-12-18
CH234453T 1942-12-18

Publications (1)

Publication Number Publication Date
CH243014A true CH243014A (en) 1946-06-15

Family

ID=25727920

Family Applications (1)

Application Number Title Priority Date Filing Date
CH243014D CH243014A (en) 1942-12-18 1942-12-18 Process for the preparation of an acylated, aliphatic aminocarboxamide.

Country Status (1)

Country Link
CH (1) CH243014A (en)

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