CH245883A - Process for the preparation of an acylated, aliphatic aminocarboxamide. - Google Patents
Process for the preparation of an acylated, aliphatic aminocarboxamide.Info
- Publication number
- CH245883A CH245883A CH245883DA CH245883A CH 245883 A CH245883 A CH 245883A CH 245883D A CH245883D A CH 245883DA CH 245883 A CH245883 A CH 245883A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- aliphatic
- acylated
- aminocarboxamide
- acid dimethylamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Darstellung eines aeylierten, aliphatisehen Aminoearbonsäureamids. Gegenstand des vorliegenden Zusatzpaten tes ist ein Verfahren zur Darstellung eines acylierten, aliphatischen Aminocarbonsäure- amids. Das Verfahren isst dadurch gekenn zeichnet,
dass ein. a - Halogen - propionsäure- dimetbylamid mit Methylamin umgesetzt und das Reaktionsprodukt acetyliert wird.
Das N-Acetyl-a-methylamino-propion- säuredimethylamid der Formel
EMI0001.0019
bildet eine farblose Flüssigkeit vom Siede punkt 103 bis 105 unter 0,04 mm.
Die neue Verbindung soll als Lösungs vermittler Verwendung finden. Beispiel: 24k Teile a - Methylamino - propionsäure- dimethylamid, Kpls 100 bis 103 (dargestellt aus a-Brom-propionsäuredimethylamid durch Erhitzen mit Methylamin) werden in 200 Teilen Äther gelöst und unter Rühren und Kühlen 7,
8 Teile Acetylchlorid zugetropft. Nach 2stündigem Rühren wird vom a-Me- thylamino-p#ropionsäuredimethylamid - chlor- hydrat abfiltriert und die ätherische Lösung mit gesättigter Kalilauge geschüttelt. Nach dem Abdestillieren des Lösungsmittels wird das Reaktionsprodukt im Hochvakuum. rek tifiziert.
Die neue Verbindung siedet bei 103 bis 105 unter 0,04 mm und ist leicht löslich in Wasser und organischen Lösungsmitteln.
Process for the preparation of an aylated, aliphatic amino carboxamide. The present additional patent is a process for the preparation of an acylated, aliphatic aminocarboxylic acid amide. The process is characterized by
the existence. a - halogen - propionic acid dimetbylamide reacted with methylamine and the reaction product is acetylated.
The N-acetyl-a-methylamino-propionic acid dimethylamide of the formula
EMI0001.0019
forms a colorless liquid with a boiling point of 103 to 105 below 0.04 mm.
The new connection should be used as a solution mediator. Example: 24k parts of a-methylamino-propionic acid dimethylamide, Kpls 100 to 103 (prepared from a-bromopropionic acid dimethylamide by heating with methylamine) are dissolved in 200 parts of ether and, with stirring and cooling, 7,
8 parts of acetyl chloride were added dropwise. After stirring for 2 hours, the a-methylamino-propionic acid dimethylamide chlorohydrate is filtered off and the ethereal solution is shaken with saturated potassium hydroxide solution. After the solvent has been distilled off, the reaction product is in a high vacuum. rectified.
The new compound boils below 0.04 mm at 103 to 105 and is easily soluble in water and organic solvents.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH245883T | 1942-12-18 | ||
CH242836T | 1942-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH245883A true CH245883A (en) | 1946-11-30 |
Family
ID=25728730
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH245883D CH245883A (en) | 1942-12-18 | 1942-12-18 | Process for the preparation of an acylated, aliphatic aminocarboxamide. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH245883A (en) |
-
1942
- 1942-12-18 CH CH245883D patent/CH245883A/en unknown
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