CH245883A - Process for the preparation of an acylated, aliphatic aminocarboxamide. - Google Patents

Process for the preparation of an acylated, aliphatic aminocarboxamide.

Info

Publication number
CH245883A
CH245883A CH245883DA CH245883A CH 245883 A CH245883 A CH 245883A CH 245883D A CH245883D A CH 245883DA CH 245883 A CH245883 A CH 245883A
Authority
CH
Switzerland
Prior art keywords
preparation
aliphatic
acylated
aminocarboxamide
acid dimethylamide
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH245883A publication Critical patent/CH245883A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Darstellung eines     aeylierten,        aliphatisehen        Aminoearbonsäureamids.       Gegenstand des vorliegenden Zusatzpaten  tes ist ein Verfahren zur     Darstellung    eines       acylierten,        aliphatischen        Aminocarbonsäure-          amids.    Das Verfahren     isst    dadurch gekenn  zeichnet,

   dass     ein.    a - Halogen -     propionsäure-          dimetbylamid        mit        Methylamin    umgesetzt und  das Reaktionsprodukt     acetyliert        wird.     



  Das     N-Acetyl-a-methylamino-propion-          säuredimethylamid    der Formel  
EMI0001.0019     
    bildet     eine    farblose Flüssigkeit vom Siede  punkt 103 bis 105  unter 0,04 mm.  



  Die neue     Verbindung    soll als Lösungs  vermittler     Verwendung        finden.            Beispiel:            24k    Teile a -     Methylamino    -     propionsäure-          dimethylamid,        Kpls    100 bis 103  (dargestellt  aus     a-Brom-propionsäuredimethylamid    durch  Erhitzen     mit        Methylamin)    werden in 200  Teilen Äther     gelöst    und     unter    Rühren und  Kühlen 7,

  8     Teile        Acetylchlorid        zugetropft.     Nach 2stündigem Rühren wird vom a-Me-         thylamino-p#ropionsäuredimethylamid    -     chlor-          hydrat        abfiltriert    und die ätherische Lösung  mit     gesättigter    Kalilauge geschüttelt. Nach  dem     Abdestillieren    des Lösungsmittels wird  das     Reaktionsprodukt    im     Hochvakuum.    rek  tifiziert.

   Die neue     Verbindung    siedet bei 103  bis 105      unter    0,04 mm und ist leicht löslich  in Wasser     und    organischen Lösungsmitteln.



  Process for the preparation of an aylated, aliphatic amino carboxamide. The present additional patent is a process for the preparation of an acylated, aliphatic aminocarboxylic acid amide. The process is characterized by

   the existence. a - halogen - propionic acid dimetbylamide reacted with methylamine and the reaction product is acetylated.



  The N-acetyl-a-methylamino-propionic acid dimethylamide of the formula
EMI0001.0019
    forms a colorless liquid with a boiling point of 103 to 105 below 0.04 mm.



  The new connection should be used as a solution mediator. Example: 24k parts of a-methylamino-propionic acid dimethylamide, Kpls 100 to 103 (prepared from a-bromopropionic acid dimethylamide by heating with methylamine) are dissolved in 200 parts of ether and, with stirring and cooling, 7,

  8 parts of acetyl chloride were added dropwise. After stirring for 2 hours, the a-methylamino-propionic acid dimethylamide chlorohydrate is filtered off and the ethereal solution is shaken with saturated potassium hydroxide solution. After the solvent has been distilled off, the reaction product is in a high vacuum. rectified.

   The new compound boils below 0.04 mm at 103 to 105 and is easily soluble in water and organic solvents.

Claims (1)

<B>PATENTANSPRUCH:</B> Verfahren zur Darstellung eines acylier- ten, aliphatischen Aminocarbonsäureamids, dadurch gekennzeichnet, dass ein a-Halogen- propionsäuredimethylamid mit Methylamin umgesetzt und das Reaktionsprodukt acety- liert wird. <B> PATENT CLAIM: </B> Process for the preparation of an acylated, aliphatic aminocarboxamide, characterized in that an α-halopropionic acid dimethylamide is reacted with methylamine and the reaction product is acetylated. Das N-Acetyl - a - methylamino - propion- säuredimethylamid der Formel EMI0001.0065 bildet eine farblose Flüssigkeit vom Siede punkt 103 bis 105 unter 0,04 mm. Die neue Verbindung soll als Lösungsver mittler Verwendung finden. The N-acetyl - a - methylamino - propionic acid dimethylamide of the formula EMI0001.0065 forms a colorless liquid with a boiling point of 103 to 105 below 0.04 mm. The new connection is to be used as a solution mediator.
CH245883D 1942-12-18 1942-12-18 Process for the preparation of an acylated, aliphatic aminocarboxamide. CH245883A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH245883T 1942-12-18
CH242836T 1942-12-18

Publications (1)

Publication Number Publication Date
CH245883A true CH245883A (en) 1946-11-30

Family

ID=25728730

Family Applications (1)

Application Number Title Priority Date Filing Date
CH245883D CH245883A (en) 1942-12-18 1942-12-18 Process for the preparation of an acylated, aliphatic aminocarboxamide.

Country Status (1)

Country Link
CH (1) CH245883A (en)

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