CH245887A - Process for the preparation of an acylated, aliphatic aminocarboxamide. - Google Patents

Process for the preparation of an acylated, aliphatic aminocarboxamide.

Info

Publication number
CH245887A
CH245887A CH245887DA CH245887A CH 245887 A CH245887 A CH 245887A CH 245887D A CH245887D A CH 245887DA CH 245887 A CH245887 A CH 245887A
Authority
CH
Switzerland
Prior art keywords
acylated
preparation
aliphatic
aminocarboxamide
acid dimethylamide
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH245887A publication Critical patent/CH245887A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Darstellung eines     acylierten,        aliphatischen        Aminocarbonsäureamids.            Gegenstand    des vorliegenden Zusatzpaten  tes ist ein Verfahren zur Darstellung eines       acylierten,        aliphatischen        Aminocarbonsäure-          amids.    Das Verfahren     ist    dadurch gekenn  zeichnet,

   dass ein     Halogen-ess.igsäuredime-          thylamid    mit     Äthylamin    umgesetzt und das  Reaktionsprodukt mit einer das Radikal der       Crotonsäure    abgebenden Verbindung     acyliert     wird.  



  Das     N-Crotonyl-äthylamino-essigsäure-          dimethylamid    der Formel  
EMI0001.0017     
    bildet eine farblose Flüssigkeit vom Siede  punkt 185 bis 186  unter 0,5 mm.  



  Die neue Verbindung soll als Lösungs  vermittler Verwendung finden.  



  <I>Beispiel:</I>  24 Teile     Ithylamino-essigsäuredimethyl-          amid,        Kp"    99 bis 102  (dargestellt aus Chlor-         essigsäuredimethylamid    durch Erhitzen mit       Äthylamin),    werden in 200 Teilen Äther  gelöst und unter Rühren und Kühlen 10,4  Teile     Crotonsäurechlorid        zugetropft.    Nach  2stündigem Rühren wird vom     Äthylamino-          essigsäuredimethylamid    - Chlorhydrat     abfil-          triert    und die ätherische Lösung mit ge  sättigter Kalilauge .geschüttelt.

   Nach dem Ab  destillieren des Lösungsmittels wird das, Reak  tionsprodukt im Hochvakuum rektifiziert. Die  neue Verbindung siedet bei 185 bis 186   unter 0,5 mm und ist leicht löslich in Wasser  und organischen Lösungsmitteln.



  Process for the preparation of an acylated, aliphatic aminocarboxamide. The present additional patent is a process for the preparation of an acylated, aliphatic aminocarboxylic acid amide. The procedure is characterized by

   that a halo-acetic acid dimethylamide is reacted with ethylamine and the reaction product is acylated with a compound that releases the crotonic acid radical.



  The N-crotonyl-ethylamino-acetic acid dimethylamide of the formula
EMI0001.0017
    forms a colorless liquid with a boiling point of 185 to 186 below 0.5 mm.



  The new connection should be used as a solution mediator.



  <I> Example: </I> 24 parts of ethylamino-acetic acid dimethyl amide, bp "99 to 102 (prepared from chloroacetic acid dimethyl amide by heating with ethylamine) are dissolved in 200 parts of ether and 10.4 parts of crotonic acid chloride are dissolved with stirring and cooling After stirring for 2 hours, the ethylaminoacetic acid dimethylamide chlorohydrate is filtered off and the ethereal solution is shaken with saturated potassium hydroxide solution.

   After the solvent has been distilled off, the reaction product is rectified in a high vacuum. The new compound boils at 185 to 186 below 0.5 mm and is easily soluble in water and organic solvents.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines acylier- ten, aliphatischen Aminocarbonsäureamids, dadurch gekennzeichnet, dass ein Halogen- essigsäuredimethylamid mit Äthylamin um gesetzt und das Reaktionsprodukt mit einer das Radikal der Crotonsäure abgebenden Ver bindung acyliert wird. PATENT CLAIM: A process for the preparation of an acylated, aliphatic aminocarboxamide, characterized in that a haloacetic acid dimethylamide is reacted with ethylamine and the reaction product is acylated with a compound which releases the crotonic acid radical. Das N-Crotonyl-äthylamino-essigsäure- dimethylamid der Formel EMI0002.0003 bildet eine farblose Flüssigkeit vom Siede punkt 185 bis l86 unter 0,5 mm. Die neue Verbindung soll als Lösungsver mittler Verwendung finden. The N-crotonyl-ethylamino-acetic acid dimethylamide of the formula EMI0002.0003 forms a colorless liquid with a boiling point of 185 to 186 below 0.5 mm. The new connection is to be used as a solution mediator.
CH245887D 1942-12-18 1942-12-18 Process for the preparation of an acylated, aliphatic aminocarboxamide. CH245887A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH242836T 1942-12-18
CH245887T 1942-12-18

Publications (1)

Publication Number Publication Date
CH245887A true CH245887A (en) 1946-11-30

Family

ID=25728734

Family Applications (1)

Application Number Title Priority Date Filing Date
CH245887D CH245887A (en) 1942-12-18 1942-12-18 Process for the preparation of an acylated, aliphatic aminocarboxamide.

Country Status (1)

Country Link
CH (1) CH245887A (en)

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