CH242836A - Process for the preparation of an acylated, aliphatic aminocarboxamide. - Google Patents

Process for the preparation of an acylated, aliphatic aminocarboxamide.

Info

Publication number
CH242836A
CH242836A CH242836DA CH242836A CH 242836 A CH242836 A CH 242836A CH 242836D A CH242836D A CH 242836DA CH 242836 A CH242836 A CH 242836A
Authority
CH
Switzerland
Prior art keywords
aminocarboxamide
acylated
aliphatic
preparation
acid dimethylamide
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH242836A publication Critical patent/CH242836A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Darstellung eines     acylierten,        aliphatischen        Aminocarbonsäureamids.       Gegenstand des vorliegenden Patentes ist       ein    Verfahren zur Darstellung eines     acylier-          ten,        aliphatischen        Aminocarbonsäureamids.     Das Verfahren ist dadurch     gekennzeichnet,     dass ein     Halogen-essigsäuredimethylamid    mit       Äthylamin    umgesetzt und das Reaktions  produkt     acetyliert    wird.  



  Das     N-Acetyl-äthylamino-essigsäuredi-          methylamid    der Formel  
EMI0001.0015     
    bildet eine farblose Flüssigkeit vom Siede  punkt 145 bis 147  unter 0,5 mm.  



  Die neue Verbindung soll als - Lösungs  vermittler Verwendung     finden.       <I>Beispiel:</I>  .24 Teile     Äthylamino-essigsäuredimethyl-          amid,        Kp"    99 bis I02  (dargestellt     aus        Chlor--          essigsäuredimethylamid    durch Erhitzen mit       Äthylamin),    werden     in    200 Teilen Äther ge  löst und unter Rühren und Kühlen 7,

  8 Teile       Acetylchlorid        zugetropft.    Nach zweistündi  gem Rühren     -wird    vom     Äthylamino-essig-          säuredimethylamid    - Chlorhydrat     abfiltriert       und die ätherische Lösung mit gesättigter       Kalilauge    geschüttelt.

   Nach dem     Abdestillie-          ren    des     Lösungsmittels    wird das Reaktions  produkt im Hochvakuum     rektifiziert.    Die  neue     Verbindung    siedet bei 145 bis 147  un  ter 0,5 mm und ist leicht löslich in Wasser  und     organischen        Lösungsmitteln.  



  Process for the preparation of an acylated, aliphatic aminocarboxamide. The present patent relates to a process for the preparation of an acylated, aliphatic aminocarboxamide. The process is characterized in that a haloacetic acid dimethylamide is reacted with ethylamine and the reaction product is acetylated.



  The N-acetyl-ethylamino-acetic acid dimethylamide of the formula
EMI0001.0015
    forms a colorless liquid with a boiling point of 145 to 147 below 0.5 mm.



  The new connection is intended to be used as a solution mediator. <I> Example: </I> .24 parts of ethylamino-acetic acid dimethyl amide, bp "99 to I02 (prepared from chloro-acetic acid dimethyl amide by heating with ethylamine), are dissolved in 200 parts of ether and, with stirring and cooling, 7,

  8 parts of acetyl chloride were added dropwise. After stirring for two hours, the ethylamino-acetic acid dimethylamide is filtered off hydrochloride and the ethereal solution is shaken with saturated potassium hydroxide solution.

   After the solvent has been distilled off, the reaction product is rectified in a high vacuum. The new compound boils at 145 to 147 below 0.5 mm and is easily soluble in water and organic solvents.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines acylier- ten, aliphatischen Aminocarbonsäureamids, dadurch gekennzeichnet, dass ein Elalogen- essigsäuredimethylämid mit Äthylamin um gesetzt und das Reaktionsprodukt acetyliert wird. PATENT CLAIM: Process for the preparation of an acylated, aliphatic aminocarboxamide, characterized in that an elalogenacetic acid dimethylamide is reacted with ethylamine and the reaction product is acetylated. Das N - Acetyl - äthylamino - essigsäure- dimethylamid der Formel EMI0001.0053 bildet eine farblose Flüssigkeit vom Siede punkt 145 bis 147 unter 5 mm. Die neue Verbindung soll als Lösungs vermittler Verwendung finden. . The N - acetyl - ethylamino - acetic acid dimethylamide of the formula EMI0001.0053 forms a colorless liquid with a boiling point of 145 to 147 below 5 mm. The new connection should be used as a solution mediator. .
CH242836D 1942-12-18 1942-12-18 Process for the preparation of an acylated, aliphatic aminocarboxamide. CH242836A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH242836T 1942-12-18

Publications (1)

Publication Number Publication Date
CH242836A true CH242836A (en) 1946-06-15

Family

ID=4463200

Family Applications (1)

Application Number Title Priority Date Filing Date
CH242836D CH242836A (en) 1942-12-18 1942-12-18 Process for the preparation of an acylated, aliphatic aminocarboxamide.

Country Status (1)

Country Link
CH (1) CH242836A (en)

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