CH240381A - Process for the preparation of an acylated, aliphatic aminocarboxamide. - Google Patents
Process for the preparation of an acylated, aliphatic aminocarboxamide.Info
- Publication number
- CH240381A CH240381A CH240381DA CH240381A CH 240381 A CH240381 A CH 240381A CH 240381D A CH240381D A CH 240381DA CH 240381 A CH240381 A CH 240381A
- Authority
- CH
- Switzerland
- Prior art keywords
- acylated
- preparation
- aliphatic
- aminocarboxamide
- butyric acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Verfahren zur Bärstellung eines acylierten, aliphatischen Aminocarbonsäureamids. Gegenstand des vorliegenden Zusatzpaten tes ist ein Verfahren zur Darstellung eines acylierten, aliphatischen Aminocarbonsäure- amids. Das Verfahren ist dadurch gekenn zeichnet,
dass ein a-Halogen-n-buttersäure- diäthylamid mit Äthylamin umgesetzt und das Reaktionsprodukt mit einer das Radikal der n-Valeriansäure abgebenden Verbindung acy liert wird. Das N-(n-Valeroyl)-a-äthylamino-n-buttersäurediäthylamidderFormel
EMI0001.0016
bildet eine farblose Flüssigkeit vom Siede punkt 124-126 unter 0,1 mm.
Die neue Verbindung soll therapeutische Verwendung finden. <I>Beispiel:</I> 37,2 Teile a-Äthylamino-n-buttersäure- diäthylamid, Kp. ", 110-114 (dargestellt aus a-Brom-n-buttersäurediäthylamid durch Er hitzen mit Äthylamin),
werden in 200 Teilen Äther gelöst und unter Rühren und Kühlen 12 Teile n-Valeriansäurechlorid zugetropft. Nach zweistündigem Rühren wird vom a - Äthylamino - n - buttersäurediäthylamid - chlorhydrat erbfiltriert und die ätherische Lö sung mit gesättigter Kalilauge geschüttelt. Nach dem Abdestillieren des Lösungsmittels wird das Reaktionsprodukt im Hochvakuum rektifiziert.
Die neue Verbindung siedet bei 124-126 unter 0,1 mm und ist mässig löslich , in Wasser und leicht in organischen Lösungs mitteln.
Process for the preparation of an acylated, aliphatic aminocarboxamide. The present additional patent is a process for the preparation of an acylated, aliphatic aminocarboxylic acid amide. The procedure is characterized by
that an α-halo-n-butyric acid diethylamide is reacted with ethylamine and the reaction product is acylated with a compound which releases the radical of n-valeric acid. The N- (n-valeroyl) -a-ethylamino-n-butyric acid diethylamide of the formula
EMI0001.0016
forms a colorless liquid with a boiling point of 124-126 below 0.1 mm.
The new compound should find therapeutic use. <I> Example: </I> 37.2 parts of a-ethylamino-n-butyric acid diethylamide, Kp. ", 110-114 (prepared from a-bromo-n-butyric acid diethylamide by heating with ethylamine),
are dissolved in 200 parts of ether and 12 parts of n-valeric acid chloride are added dropwise with stirring and cooling. After stirring for two hours, the a-ethylamino-n-butyric acid diethylamide chlorohydrate is filtered off and the ethereal solution is shaken with saturated potassium hydroxide solution. After the solvent has been distilled off, the reaction product is rectified in a high vacuum.
The new compound boils below 0.1 mm at 124-126 and is sparingly soluble in water and slightly in organic solvents.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH240381T | 1942-12-18 | ||
CH234453T | 1942-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH240381A true CH240381A (en) | 1945-12-15 |
Family
ID=25727898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH240381D CH240381A (en) | 1942-12-18 | 1942-12-18 | Process for the preparation of an acylated, aliphatic aminocarboxamide. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH240381A (en) |
-
1942
- 1942-12-18 CH CH240381D patent/CH240381A/en unknown
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