CH240379A - Process for the preparation of an acylated, aliphatic aminocarboxamide. - Google Patents

Process for the preparation of an acylated, aliphatic aminocarboxamide.

Info

Publication number
CH240379A
CH240379A CH240379DA CH240379A CH 240379 A CH240379 A CH 240379A CH 240379D A CH240379D A CH 240379DA CH 240379 A CH240379 A CH 240379A
Authority
CH
Switzerland
Prior art keywords
acylated
preparation
aliphatic
acid
aminocarboxamide
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH240379A publication Critical patent/CH240379A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Darstellung eines     acylierten,        aliphatischen        Aminocarbonsäureamids.       Gegenstand des vorliegenden Zusatz  patentes ist ein Verfahren zur Darstellung  eines     acylierten,        aliphatischen        Aminocarbon-          säureamids.    Das     Verfahrenist    dadurch gekenn  zeichnet,

   dass ein     a-Halogen-propionsäure-          dimethylamid    mit     Äthylamin    umgesetzt     und     das Reaktionsprodukt mit einer das Radikal  der     Trimethylacrylsäure    abgebenden Verbin  dung     acyliert    wird.  



  Das N -     Trimethylacroyl    - a -     äthylamino        -          propionsäuredimethylamid    der Formel  
EMI0001.0019     
    bildet eine farblose Flüssigkeit vom Siede  punkt     134-136     unter 0,3 mm.  



  Die neue Verbindung soll     therapeutische     Verwendung finden.    <I>Beispiel:</I>  27 Teile a -     Äthylamino    -     propionsäure-          dimethylamid,        gp13        98-1G0"    (dargestellt  aus     a-Brom-propionsäuredimethylamid    durch  Erhitzen mit     Äthylamin),    werden in 200  Teilen Äther gelöst und unter Rühren und  Kühlen 13 Teile     Trimethylacrylsäurechlorid          zugetropft.    Nach 2stündigem Rühren wird  vom     ,

  a    -     Äthylamino    -     propionsäuredimethyl-          amidchlorhydrat        abfiltriert    und die ätherische  Lösung mit gesättigter Kalilauge geschüttelt.  Nach dem     Abdestillieren    des Lösungsmittels  wird das Reaktionsprodukt im Hochvakuum  rektifiziert. Die neue     Verbindung    siedet bei       134-136     unter 0,3     mm    und ist leicht löslich  in Wasser und organischen     Lösungsmitteln.  



  Process for the preparation of an acylated, aliphatic aminocarboxamide. The subject of the present additional patent is a process for the preparation of an acylated, aliphatic aminocarboxylic acid amide. The procedure is characterized by

   that an α-halopropionic acid dimethylamide is reacted with ethylamine and the reaction product is acylated with a compound which gives off the radical of trimethylacrylic acid.



  The N - trimethylacroyl - a - ethylamino - propionic acid dimethylamide of the formula
EMI0001.0019
    forms a colorless liquid with a boiling point of 134-136 below 0.3 mm.



  The new compound should find therapeutic use. <I> Example: </I> 27 parts of a - ethylamino - propionic acid dimethylamide, gp13 98-1G0 "(prepared from a-bromopropionic acid dimethylamide by heating with ethylamine) are dissolved in 200 parts of ether and, with stirring and cooling, 13 Parts of trimethylacrylic acid chloride are added dropwise. After stirring for 2 hours, the

  a - Ethylamino - propionic acid dimethyl amide chlorohydrate filtered off and the ethereal solution shaken with saturated potassium hydroxide solution. After the solvent has been distilled off, the reaction product is rectified in a high vacuum. The new compound boils below 0.3 mm at 134-136 and is easily soluble in water and organic solvents.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines acylier- ten, aliphatischen Aminocarbonsä,ureamids, dadurch gekennzeichnet, dass ein a-Halogen- propionsäuredimethylamid mit Äthylamin umgesetzt und das Reaktionsprodukt mit einer das Radikal der Trimethylacrylsäure abgebenden Verbindung acyliert wird. PATENT CLAIM: Process for the preparation of an acylated, aliphatic aminocarboxylic acid amide, characterized in that an α-halopropionic acid dimethylamide is reacted with ethylamine and the reaction product is acylated with a compound which gives off the radical of the trimethylacrylic acid. Das _N-Trimethylacroyl-a-äthylamino- propionsäuredimetbylamid der Formel EMI0002.0005 bildet eine farblose Flüssigkeit vom Siede punkt 134-136 unter 0,3 Mn. Die neue Verbindung soll therapeutische Verwendung finden. The _N-trimethylacroyl-a-ethylamino propionic acid dimetbylamide of the formula EMI0002.0005 forms a colorless liquid with a boiling point of 134-136 below 0.3 Mn. The new compound should find therapeutic use.
CH240379D 1942-12-18 1942-12-18 Process for the preparation of an acylated, aliphatic aminocarboxamide. CH240379A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH234453T 1942-12-18
CH240379T 1942-12-18

Publications (1)

Publication Number Publication Date
CH240379A true CH240379A (en) 1945-12-15

Family

ID=25727896

Family Applications (1)

Application Number Title Priority Date Filing Date
CH240379D CH240379A (en) 1942-12-18 1942-12-18 Process for the preparation of an acylated, aliphatic aminocarboxamide.

Country Status (1)

Country Link
CH (1) CH240379A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7056935B2 (en) 1995-06-07 2006-06-06 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7056935B2 (en) 1995-06-07 2006-06-06 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors

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