CH268084A - Process for the preparation of an acylated aliphatic aminocarboxamide. - Google Patents

Process for the preparation of an acylated aliphatic aminocarboxamide.

Info

Publication number
CH268084A
CH268084A CH268084DA CH268084A CH 268084 A CH268084 A CH 268084A CH 268084D A CH268084D A CH 268084DA CH 268084 A CH268084 A CH 268084A
Authority
CH
Switzerland
Prior art keywords
aminocarboxamide
preparation
valeric acid
acylated aliphatic
hydrogenation
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH268084A publication Critical patent/CH268084A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Darstellung eines     acylierten        aliphatischen        Aminocarbonsäureamides.       Gegenstand vorliegenden Patentes ist ein  Verfahren zur Darstellung eines     acylierten          aliphatischen        Aminocarbonsäureamides.    Das  Verfahren ist dadurch gekennzeichnet, dass  man     N-Crotonyl-a-äthylamino-n-valeriansäure-          dimethylamid    reduziert.

   Die entstandene neue  Verbindung, das     N-Butyroy        1-a-äthylamino-n-          valeriansäure-dimethylamid    der Formel  
EMI0001.0012     
    bildet eine farblose Flüssigkeit vom Siede  punkt. 119 bis 120  unter 0,02 mm Druck. Sie  soll therapeutische Verwendung finden.  



  <I>Beispiel:</I>  24 Teile     N-Crotonyl-a-äthylamino-n-vale-          riansäure-dimethylamid    werden in 100 Teilen       50o/oigem    Alkohol gelöst, mit 2,5 Teilen       Raney-Nickel    versetzt und mit Wasserstoff  bei Zimmertemperatur geschüttelt. Sobald die  berechnete Menge Wasserstoff aufgenommen  ist, wird vom Katalysator     abfiltriert,    der Al  kohol     abdestilliert    und die     wässrige    Lösung  mit     Kaliumhydroxyd    gesättigt. Das abge  schiedene öl wird in     Xylol    aufgenommen  getrocknet.

   Nach     Abdestillieren    des Lösungs  mittels wird das N-Butyroyl-a-äthylamino-n-         valeriansäure-dimethylamid    im Hochvakuum  destilliert. Es siedet unter 0,02 mm bei 119  bis 120 . Statt bei Zimmertemperatur kann  die Hydrierung auch bei 60  ausgeführt  werden.



  Process for the preparation of an acylated aliphatic aminocarboxamide. The present patent relates to a process for the preparation of an acylated aliphatic aminocarboxamide. The process is characterized in that N-crotonyl-a-ethylamino-n-valeric acid dimethylamide is reduced.

   The resulting new compound, the N-Butyroy 1-a-ethylamino-n-valeric acid dimethylamide of the formula
EMI0001.0012
    forms a colorless liquid from the boiling point. 119 to 120 under 0.02 mm pressure. It should find therapeutic use.



  <I> Example: </I> 24 parts of N-crotonyl-a-ethylamino-n-valeric acid dimethylamide are dissolved in 100 parts of 50% alcohol, 2.5 parts of Raney nickel are added and hydrogen is added at room temperature shaken. As soon as the calculated amount of hydrogen has been absorbed, the catalyst is filtered off, the alcohol is distilled off and the aqueous solution is saturated with potassium hydroxide. The separated oil is taken up in xylene and dried.

   After the solvent has been distilled off, the N-butyroyl-a-ethylamino-n-valeric acid dimethylamide is distilled in a high vacuum. It boils below 0.02 mm at 119 to 120. The hydrogenation can also be carried out at 60 instead of at room temperature.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines acylierten aliphatischen Aminocarbonsäureamides, da durch gekennzeichnet, dass man N-Crotonyl- a - äthylamino -n-valeriansäure- dimethylamid reduziert. Die entstandene neue Verbindung, das N-Butyroyl-a-äthyla.mino-n-valeriansäure- dimet.hylamid der Formel EMI0001.0034 bildet eine farblose Flüssigkeit vom Siedepunkt 119 bis 120 unter 0,02 mm Druck. UNTERANSPRÜCHE: 1. PATENT CLAIM: Process for the preparation of an acylated aliphatic aminocarboxamide, characterized in that N-crotonyl-a-ethylamino-n-valeric acid dimethylamide is reduced. The resulting new compound, the N-butyroyl-a-äthyla.mino-n-valeric acid dimet.hylamide of the formula EMI0001.0034 forms a colorless liquid with a boiling point of 119 to 120 under 0.02 mm pressure. SUBCLAIMS: 1. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man die Reduk tion durch Hydrierung in Gegenwart von Raney-Nickel durchführt. 2. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man die Reduk tion durch Hydrierung bei erhöhter Tem peratur ausführt. Process according to patent claim, characterized in that the reduction is carried out by hydrogenation in the presence of Raney nickel. 2. The method according to claim, characterized in that the reduction is carried out by hydrogenation at elevated tem perature.
CH268084D 1944-06-07 1944-06-07 Process for the preparation of an acylated aliphatic aminocarboxamide. CH268084A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH268084T 1944-06-07
CH254949T 1946-07-01

Publications (1)

Publication Number Publication Date
CH268084A true CH268084A (en) 1950-04-30

Family

ID=25729879

Family Applications (1)

Application Number Title Priority Date Filing Date
CH268084D CH268084A (en) 1944-06-07 1944-06-07 Process for the preparation of an acylated aliphatic aminocarboxamide.

Country Status (1)

Country Link
CH (1) CH268084A (en)

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