CH224345A - Process for the preparation of methylamino-5-hexene-1. - Google Patents

Process for the preparation of methylamino-5-hexene-1.

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Publication number
CH224345A
CH224345A CH224345DA CH224345A CH 224345 A CH224345 A CH 224345A CH 224345D A CH224345D A CH 224345DA CH 224345 A CH224345 A CH 224345A
Authority
CH
Switzerland
Prior art keywords
methylamino
hexene
preparation
amino
hexen
Prior art date
Application number
Other languages
German (de)
Inventor
Fabriken Knoll A-G Chemische
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Publication of CH224345A publication Critical patent/CH224345A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung     -von        l)iethylamino-5-hegen-1.       Das Hauptpatent hat zum Gegenstand ein  Verfahren zur Herstellung von     Methylamino-          6-methyl-2-hepten-2,    welches sich durch wert  volle krampflösende Wirkung auszeichnet.  Diese Verbindung wird gemäss dem Verfah  ren des Hauptpatentes dadurch hergestellt,       d.ass    man     Amino-6-methyl-2-hepten-2    mit  einem     methylierenden    Mittel behandelt.  



  Das vorliegende Patent bezieht sich auf  ein Verfahren zur Herstellung von     Methyl-          amino-5-hexen-1,    einer neuen und wertvollen  chemischen Verbindung, die sich ebenfalls  durch ihre günstige krampflösende Eigen  schaft auszeichnet. Dieses Verfahren ist da  durch gekennzeichnet, dass man     Amino-5-          hexen-1    mit     Benzaldehyd    umsetzt und das  Umsetzungsprodukt mit einem     methylieren-          den    Mittel behandelt.  



  Das     Methylamino-5-hexen-1,        C,H"N,    ist  eine leichtbewegliche, farblose Flüssigkeit    von stark     ammoniakalischem    Geruch; sie ist  in den meisten organischen     Lösungsmitteln     löslich, in Wasser unlöslich     und    siedet bei  128 bis<B>130'.</B>  



  Die beschriebene     Verbindung    soll zum  Aufbau von Arzneimitteln dienen.  



       Beispiel:     39,6 g     Amino-5-hexen-1    und 45g Benz  aldehyd werden kondensiert und das sich ab  scheidende Wasser auf dem Wasserbad     unter     vermindertem Druck entfernt. Nach Zugabe  von 60 g     Methyljodid    oder 52 g     Dimethyl-          sulfat    wird das Gemisch am     Rückfluss    er  hitzt.

   Nach beendeter Umsetzung spaltet man  den     Benzald@ehyd    mit verdünnter Mineral  säure wieder ab und entfernt denselben durch       Wasserdampfdestillation.        Auf    Zusatz von  Alkali     wird    das     Methylamino-5-hexen-1    in  Freiheit gesetzt     und    mit Wasserdampf über  getrieben.



  Process for the preparation of l) ethylamino-5-hegen-1. The subject of the main patent is a process for the preparation of methylamino-6-methyl-2-hepten-2, which is characterized by its valuable antispasmodic effect. This compound is produced according to the method of the main patent by treating amino-6-methyl-2-hepten-2 with a methylating agent.



  The present patent relates to a process for the production of methyl-amino-5-hexene-1, a new and valuable chemical compound, which is also characterized by its favorable antispasmodic property. This process is characterized in that amino-5-hexene-1 is reacted with benzaldehyde and the reaction product is treated with a methylating agent.



  Methylamino-5-hexen-1, C, H "N, is an easily mobile, colorless liquid with a strong ammoniacal odor; it is soluble in most organic solvents, insoluble in water and boils at 128 to 130 ° / B>



  The compound described is intended to be used to build drugs.



       Example: 39.6 g of amino-5-hexen-1 and 45 g of benzaldehyde are condensed and the water which separates out is removed on the water bath under reduced pressure. After adding 60 g of methyl iodide or 52 g of dimethyl sulfate, the mixture is refluxed.

   After the reaction has ended, the benzaldehyde is split off again with dilute mineral acid and the same is removed by steam distillation. Upon addition of alkali, the methylamino-5-hexen-1 is set free and driven over with steam.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von Methyl- amin-5-hegen-1, dadurch gekennzeichnet, daB man Amino-5-hexen-1 mit Benzaldehyd um setzt und das Umsetzungsprodukt mit einem methylierenden Mittel behandelt. PATENT CLAIM: Process for the production of methylamine-5-hegen-1, characterized in that amino-5-hexen-1 is reacted with benzaldehyde and the reaction product is treated with a methylating agent. Die neue Base ist eine leichtbewegliche, farblose Flüssigkeit mit stark ammoniakali- schem Geruch; sie ist in den meisten organi schen Lösungsmitteln löslich, in Wasser un löslich und siedet unter gewöhnlichem Druck bei 128 bis <B>130'.</B> The new base is an easily mobile, colorless liquid with a strong ammoniacal odor; it is soluble in most organic solvents, insoluble in water and boils under normal pressure at 128 to 130 '. </B>
CH224345D 1937-02-15 1938-02-14 Process for the preparation of methylamino-5-hexene-1. CH224345A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE224345X 1937-02-15
CH166214T 1938-02-14

Publications (1)

Publication Number Publication Date
CH224345A true CH224345A (en) 1942-11-15

Family

ID=25718239

Family Applications (1)

Application Number Title Priority Date Filing Date
CH224345D CH224345A (en) 1937-02-15 1938-02-14 Process for the preparation of methylamino-5-hexene-1.

Country Status (1)

Country Link
CH (1) CH224345A (en)

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