CH223653A - Process for the preparation of methylamino-6-methyl-2-heptane. - Google Patents

Process for the preparation of methylamino-6-methyl-2-heptane.

Info

Publication number
CH223653A
CH223653A CH223653DA CH223653A CH 223653 A CH223653 A CH 223653A CH 223653D A CH223653D A CH 223653DA CH 223653 A CH223653 A CH 223653A
Authority
CH
Switzerland
Prior art keywords
methyl
heptane
act
allowed
reducing agent
Prior art date
Application number
Other languages
German (de)
Inventor
Fabriken Knoll A-G Chemische
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Publication of CH223653A publication Critical patent/CH223653A/en

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

  

      'Verfahren    zur Herstellung von     Methylamino-6-methyl-2-heptan.       Das vorliegende Patent bezieht sich auf  ein Verfahren zur     Herstellung    von     Methyl-          amino-6-methyl-2-heptan,    einer neuen und  wertvollen chemischen Verbindung, die- sich  durch ihre günstige     krampflösende    Eigen  schaft auszeichnet.  



  Diese neue Verbindung wird erfindungsge  mäss dadurch     hergestellt,        .dass    man     Methyl-2-          heptanon-6        CH#,.        CH(CH3)    .     (CHZ)3        #    C0.     CH;;,          Methylamin    und ein Reduktionsmittel,  zweckmässig     naszierenden        Wasserstoff,    auf  einander     einwirken    lässt.

   Die Kondensation       und    die     Reduktion    können sowohl gleichzei  tig als, auch     aufeinanderfoigend    durchge  führt werden.  



  Das     Methylamino-6-methyl-2-heptan    ist  eine farblose Flüssigkeit von stark basischem  Geruch; sie ist in den meisten organischen  Lösungsmitteln löslich, in Wasser unlöslich.  Sie siedet unter 10 mm Druck bei<B>62-63'.</B>  Das     Bitartrat    der Base, welches aus Alkohol-         äther    umgelöst werden kann, .schmilzt bei  <B>84-860.</B>  



  <I>Beispiel:</I>  38,4 g     Methyl-2-heptano#n-6,    gelöst in  300 cm' 75%igem Alkohol, 15 g     Methyl-          amin    und 30 .g aktiviertes Aluminium wer  den aufeinander einwirken gelassen. Nach be  endigter Reaktion     wird    das Reaktionsge  misch     mit    verdünnter Mineralsäure versetzt  und der Alkohol     abdestilliert.    Auf Zusatz  von Alkali scheidet sich     Methyla@mino-6-          m-etlhyl-2-heptan    als ölige     Flüssigkeit    ab,  welche mit     Wasserdampf    übergetrieben wird.



      'Process for the preparation of methylamino-6-methyl-2-heptane. The present patent relates to a process for the production of methyl-amino-6-methyl-2-heptane, a new and valuable chemical compound which is characterized by its favorable antispasmodic property.



  According to the invention, this new compound is prepared by adding methyl-2-heptanone-6 CH #,. CH (CH3). (CHZ) 3 # C0. CH ;;, methylamine and a reducing agent, suitably nascent hydrogen, can act on each other.

   The condensation and the reduction can be carried out both simultaneously and in succession.



  Methylamino-6-methyl-2-heptane is a colorless liquid with a strong basic odor; it is soluble in most organic solvents and insoluble in water. It boils under 10 mm pressure at <B> 62-63 '. </B> The bitartrate of the base, which can be redissolved from alcohol ether, melts at <B> 84-860. </B>



  <I> Example: </I> 38.4 g of methyl-2-heptano # n-6, dissolved in 300 cm 'of 75% alcohol, 15 g of methylamine and 30 g of activated aluminum are allowed to interact. When the reaction has ended, dilute mineral acid is added to the reaction mixture and the alcohol is distilled off. When alkali is added, Methyla @ mino-6-m-ethyl-2-heptane separates out as an oily liquid which is blown over with steam.

Claims (1)

PATENTANSPRUCH: Verfahren: zur Herstellung von Methyl- amino-6-:methyl-2-heptan,dadurch gekenn zeichnet, dass, man Methyl - 2 - heptanon - 6, Methylamin und ein Reduktionsmittel auf einander einwirken lässt. Die neue Base ist eine farblose Flüssig keit von stark basischem Geruch, welche in den meisten organischen Lösungsmitteln lös lich, in Wasser unlöslich ist. PATENT CLAIM: Process: for the production of methyl-amino-6-: methyl-2-heptane, characterized in that methyl - 2 - heptanone - 6, methylamine and a reducing agent are allowed to act on one another. The new base is a colorless liquid with a strong basic odor, which is soluble in most organic solvents and insoluble in water. Sie siedet unter 10 mm Druck bei <B>62-63'.</B> Ihr Bitartrat kristallisiert aus Alkoholäther bei 84-86 . UNTERAN SPRüCHE 1. Verfahren nach Patentanspruch, da durch gekennzeichnet, daB dass Keton, das Methylamin und das Reduktionsmittel gleich- -zeitig aufeinander einwirken gelassen wer den. 2. It boils under 10 mm pressure at <B> 62-63 '. </B> Your bitartrate crystallizes from alcohol ether at 84-86. SUBSTITUTE DISCLAIMERS 1. A method according to claim, characterized in that the ketone, the methylamine and the reducing agent are allowed to act on one another at the same time. 2. Verfahren nach Patentanspruch, da durch .gekennzeichnet, da,B das Amin mit dem Keton kondensiert und auf das so erhaltene Kondensationsprodukt das Reduktionsmittel einwirken gelassen wird. Process according to claim, characterized by .gekisiert, da, B the amine is condensed with the ketone and the reducing agent is allowed to act on the condensation product thus obtained.
CH223653D 1937-02-15 1938-02-09 Process for the preparation of methylamino-6-methyl-2-heptane. CH223653A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE223653X 1937-02-15

Publications (1)

Publication Number Publication Date
CH223653A true CH223653A (en) 1942-09-30

Family

ID=5851664

Family Applications (1)

Application Number Title Priority Date Filing Date
CH223653D CH223653A (en) 1937-02-15 1938-02-09 Process for the preparation of methylamino-6-methyl-2-heptane.

Country Status (1)

Country Link
CH (1) CH223653A (en)

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