CH223652A - Process for the preparation of methylamino- (6) -methyl- (2) -heptane. - Google Patents

Process for the preparation of methylamino- (6) -methyl- (2) -heptane.

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Publication number
CH223652A
CH223652A CH223652DA CH223652A CH 223652 A CH223652 A CH 223652A CH 223652D A CH223652D A CH 223652DA CH 223652 A CH223652 A CH 223652A
Authority
CH
Switzerland
Prior art keywords
methyl
heptane
methylamino
amino
preparation
Prior art date
Application number
Other languages
German (de)
Inventor
Fabriken Knoll A-G Chemische
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Publication of CH223652A publication Critical patent/CH223652A/en

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Description

  

  Verfahren zur Herstellung von     lllethylamino-(6)-methyl-(2)-heptan.       Die Erfindung bezieht sich auf die Her  stellung von     Methylamino    - (6) -     methyl-        (2)-          heptan,einer    neuen und wertvollen chemi  schen     Verbindung,    die sieh durch ihre gün  stige krampflösende Eigenschaft auszeichnet.  



  Die neue Verbindung wird erfindungsge  mäss dadurch hergestellt, dass die entspre  chende     Norbase        Amino-(6)-methyl-(2)-hep-          tan    mit     Benzaldehyd    kondensiert, das Kon  densationsprodukt mit     methylierenden        i1Zit-          teln    behandelt     und,das        Methylierungspro.dukt     mit Säure zersetzt wird. Als     methylierende     Mittel kommen insbesondere in Betracht       Methyljodid    oder     Dimethylsulfat.     



  Das     Methylamino--    (6)     -methyl-    (2)     -heptan     ist eine farblose Flüssigkeit von stark     bas.i-          sehem    Geruch; sie ist in den meisten organi  schen Lösungsmitteln löslich,     in    Wasser     un-          löslieh.    Sie siedet unter 10 mm Druck bei  <B>62-63'.</B> Das.     Bitartrat    der Base, welches  aus Alkoholäther umgelöst werden kann,  schmilzt bei     84-86     .

      <I>Beispiel:</I>  26 g     Amino-(6)-methyl-,(2)-heptan    und  24 g     Benzal@dehyd    werden auf dem Wasser  bad erwärmt und das sich abscheidende Was  ser unter     vermindertem    Druck     entfernt.    Nach  Zusatz von 30g     Methyljodid        oder    26g     Di-          methylsulfat    wird das Gemisch     einige    Zeit  erhitzt und     das,        Reaktionspradukt    :darauf mit  verdünnter     Mineralsäure    versetzt.

   Der sich  hierbei     abspaltende        Benzaldehyd    wird durch       Destillation    mit Wasserdampf entfernt und  auf diese Weise zurückgewonnen. Durch Zu  gabe von Alkali zu der sauren Lösung wird  die     methylierte    Base in Freiheit     gesetzt    und  der Lösung durch     Ausschütteln    mit Äther  entzogen.



  Process for the preparation of IIIethylamino- (6) -methyl- (2) -heptane. The invention relates to the manufacture of methylamino - (6) - methyl- (2) - heptane, a new and valuable chemical compound which is characterized by its favorable antispasmodic property.



  According to the invention, the new compound is produced by condensing the corresponding norbase amino (6) methyl (2) heptane with benzaldehyde, treating the condensation product with methylating agents and treating the methylation product with acid is decomposed. Methyl iodide or dimethyl sulfate are particularly suitable as methylating agents.



  Methylamino- (6) -methyl- (2) -heptane is a colorless liquid with a strong basic odor; it is soluble in most organic solvents and insoluble in water. It boils under 10 mm pressure at <B> 62-63 '. </B> That. Bitartrate of the base, which can be redissolved from alcohol ether, melts at 84-86.

      <I> Example: </I> 26 g of amino- (6) -methyl-, (2) -heptane and 24 g of benzaldehyde are heated on the water bath and the water that separates out is removed under reduced pressure. After adding 30 g of methyl iodide or 26 g of dimethyl sulfate, the mixture is heated for some time and the reaction product is then mixed with dilute mineral acid.

   The benzaldehyde that is split off is removed by distillation with steam and recovered in this way. By adding alkali to the acidic solution, the methylated base is set free and removed from the solution by shaking with ether.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von biethyl- , amino-(6)-methyl-(2)-heptan, dadurch ge kennzeichnet, dass Amino - (6) - methyl - (2) - heptan mit Benzaldehyd kondensiert und das Kondensationsprodukt mit methylierenden Mitteln behandelt und das Methylierungspro- dukt mit Säure zersetzt wird. PATENT CLAIM: Process for the production of ethyl, amino (6) methyl (2) heptane, characterized in that amino (6) methyl (2) heptane condenses with benzaldehyde and the condensation product with methylating agents treated and the methylation product is decomposed with acid. Die neue Base ist eine farblose Flüsssig- keit von stark basischem Geruch, welche in den meisten organischen Lösungsmitteln lös- lich, in Wasser unlöslich ist. Sie siedet unter 10 mm Druck bei 62-63 . Ihr Bitartrat kritallisiert aus Alkoholäther bei 84-86 . The new base is a colorless liquid with a strong basic odor, which is soluble in most organic solvents and insoluble in water. It boils under 10 mm pressure at 62-63. Your bitartrate criticized from alcohol ether at 84-86.
CH223652D 1937-02-15 1938-02-09 Process for the preparation of methylamino- (6) -methyl- (2) -heptane. CH223652A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE223652X 1937-02-15

Publications (1)

Publication Number Publication Date
CH223652A true CH223652A (en) 1942-09-30

Family

ID=5851654

Family Applications (1)

Application Number Title Priority Date Filing Date
CH223652D CH223652A (en) 1937-02-15 1938-02-09 Process for the preparation of methylamino- (6) -methyl- (2) -heptane.

Country Status (1)

Country Link
CH (1) CH223652A (en)

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