CH214348A - Process for the preparation of a therapeutically useful sulfo compound. - Google Patents

Process for the preparation of a therapeutically useful sulfo compound.

Info

Publication number
CH214348A
CH214348A CH214348DA CH214348A CH 214348 A CH214348 A CH 214348A CH 214348D A CH214348D A CH 214348DA CH 214348 A CH214348 A CH 214348A
Authority
CH
Switzerland
Prior art keywords
preparation
condensation
dependent
carried out
condensing agent
Prior art date
Application number
Other languages
German (de)
Inventor
Schering A G
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of CH214348A publication Critical patent/CH214348A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung einer therapeutisch wertvollen     Sulfoverbindung.            Gegenstand    des vorliegenden Patentes ist       ein    Verfahren zur Herstellung einer thera  peutisch, z. B. bei     Kokkeninfektionen,    ins  besondere bei     Streptokokkeninfektionen    wert  vollen     Sulfoverbindung,    das dadurch gekenn  zeichnet ist, dass man     Sulfanilsäureamid    mit       Galactose    kondensiert.  



  Die Kondensation wird am besten in  wässriger Lösung, zweckmässig in Gegenwart  eines Kondensationsmittels bei 90 bis<B>100'</B>       ausgeführt,    doch     -sind    auch     Lösungen    der       Ausgangsmaterialien    in organischen, mit  Wasser mischbaren Lösungsmitteln anwend  bar; auch ein direktes Zusammenschmelzen  der Komponenten ist möglich. Als Konden  sationsmittel eignen sich insbesondere Am  monsalze, wie     Ammonchlorid,        Kaliumbisul-          fat,    Zinkchlorid oder andere schwach sauer  wirkende Mittel.  



  <I>Beispiel:</I>  10 g     Sulfanilsäureamid    werden mit 20 g       Galaetose        und    0,5 g     Ammoniumchlorid    in  100 cm' Wasser 4     Stunden    auf dem Wasser-    bade erhitzt. Der beim     Einengen    hinterblei  bende Sirup ist in Wasser sehr leicht löslich.



  Process for the preparation of a therapeutically useful sulfo compound. The present patent is a process for the preparation of a thera peutisch, z. B. in cocci infections, especially in streptococcal infections valuable sulfo compound, which is characterized in that sulfanilic acid amide is condensed with galactose.



  The condensation is best carried out in aqueous solution, suitably in the presence of a condensing agent at 90 to 100 ', but solutions of the starting materials in organic, water-miscible solvents are also applicable; Direct melting of the components is also possible. Ammonium salts such as ammonium chloride, potassium bisulfate, zinc chloride or other weakly acidic agents are particularly suitable as condensation agents.



  <I> Example: </I> 10 g of sulfanilic acid amide are heated with 20 g of galaetose and 0.5 g of ammonium chloride in 100 cm of water for 4 hours on the water bath. The syrup that remains after concentrating is very easily soluble in water.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer therapeu tisch wertvollen Sulfoverbindung, dadurch gekennzeichnet, dass man Sulfanilsäureamid mit Galactose kondensiert. Die neue Verbindung bildet einen in Wasser leicht löslichen Sirup. UNTERANSPRüCHE 1. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass die Kondensation in wässriger Lösung bei Wasserbadtemperatur durchgeführt wird. 2. PATENT CLAIM: Process for the production of a therapeutically valuable sulfo compound, characterized in that sulfanilic acid amide is condensed with galactose. The new compound forms a syrup that is easily soluble in water. SUBClaims 1. The method according to claim, characterized in that the condensation is carried out in an aqueous solution at water bath temperature. 2. Verfahren nach Patentanspruch und Unteranspruch 1, dadurch gekennzeichnet, dass die Kondensation in konzentrierter wäss riger Lösung ausgeführt wird. 3. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass die Kondensation bei Gegenwart eines schwach sauer wirken den Kondensationsmittels durchgeführt wird. 4. Verfahren nach Patentanspruch und Unteranspruch 3, dadurch gekennzeichnet, dass als Kondensationsmittel ein Ammonsalz verwendet wird. 5. Method according to claim and dependent claim 1, characterized in that the condensation is carried out in a concentrated aqueous solution. 3. The method according to claim, characterized in that the condensation is carried out in the presence of a weakly acidic act the condensing agent. 4. The method according to claim and dependent claim 3, characterized in that an ammonium salt is used as the condensing agent. 5. Verfahren nach Patentanspruch und Unteranspruch 4, dadurch gekennzeichnet, dass als Kondensationsmittel Ammonchlorid verwendet wird. Method according to patent claim and dependent claim 4, characterized in that ammon chloride is used as the condensing agent.
CH214348D 1937-06-01 1938-05-31 Process for the preparation of a therapeutically useful sulfo compound. CH214348A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE214348X 1937-06-01
CH210681T 1937-08-16

Publications (1)

Publication Number Publication Date
CH214348A true CH214348A (en) 1941-04-15

Family

ID=25724934

Family Applications (1)

Application Number Title Priority Date Filing Date
CH214348D CH214348A (en) 1937-06-01 1938-05-31 Process for the preparation of a therapeutically useful sulfo compound.

Country Status (1)

Country Link
CH (1) CH214348A (en)

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