CH139075A - Process for the preparation of an o-oxybenzyl-aroylamine-arsic acid. - Google Patents

Process for the preparation of an o-oxybenzyl-aroylamine-arsic acid.

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Publication number
CH139075A
CH139075A CH139075DA CH139075A CH 139075 A CH139075 A CH 139075A CH 139075D A CH139075D A CH 139075DA CH 139075 A CH139075 A CH 139075A
Authority
CH
Switzerland
Prior art keywords
oxybenzyl
preparation
acid
dilute
aroylamine
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH139075A publication Critical patent/CH139075A/en

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Description

  

  Verfahren zur Herstellung einer     o-Ogybenzyl-aroylamin-arsinsäure.       Vorliegendes Patent bezieht sich auf ein  Verfahren zur Herstellung der     3-Methyl-2-          oxybenzyl-phthalimid-0'-arsinsäure    der Formel  
EMI0001.0004     
         welches    dadurch gekennzeichnet ist, dass man       3-Methyl-4-oxyphenyl-l-arsinsäure    in saurer  Lösung mit     Oxymethylphthalimid    kondensiert.  



  Die     3-Methyl-2-oxybenzyl-phthalimid-5-          arsinsäure    stellt ein weisses Pulver dar  vom Schmelzpunkt ungefähr 273 . Sie ist  leicht löslich in verdünnten Alkalien, in ver  dünnter Soda- und     Acetatlösung,,    schwerer in  heissem Spiritus und     unlöslich.iri    Äther, Ben  zol, Benzin und in verdünnten Säuren. Sie  soll für pharmazeutische Zwecke und zur    Herstellung weitet-er pharmazeutischer Pro  dukte verwendet werden.

      <I>Beispiel:</I>    310 kg     3-methyl-4-oxypbeciyl-l-ar-sinsaures     Natrium und 180 kg     Oxymethylphthalimid     werden gut gemischt und unter Kühlung in  600 kg Schwefelsäure von 66      Be    bei einer  Temperatur von     20-2ä     eingetragen. Nach  24 Stunden giesst man auf Eiswasser. Der  so gebildete weisse kristallinische Niederschlag  wird     abfiltriert,    mit Wasser neutral gewa  schen und in der berechneten Menge kalter       Sodalösung    gelöst. Man filtriert und fällt  durch Ansäuern.



  Process for the preparation of an o-ogybenzyl-aroylamine-arsic acid. The present patent relates to a process for the preparation of 3-methyl-2-oxybenzyl-phthalimide-0'-arsic acid of the formula
EMI0001.0004
         which is characterized in that 3-methyl-4-oxyphenyl-1-arsinic acid is condensed in acidic solution with oxymethylphthalimide.



  3-methyl-2-oxybenzyl-phthalimid-5-arsic acid is a white powder with a melting point of about 273. It is easily soluble in dilute alkalis, in dilute soda and acetate solutions, more difficult in hot alcohol and insoluble in ether, benzene, gasoline and in dilute acids. It is intended to be used for pharmaceutical purposes and for the manufacture of pharmaceutical products.

      <I> Example: </I> 310 kg of 3-methyl-4-oxypbeciyl-1-ar-acidic sodium and 180 kg of oxymethylphthalimide are mixed well and, with cooling, introduced into 600 kg of sulfuric acid of 66 Be at a temperature of 20-2ä . After 24 hours, it is poured onto ice water. The white crystalline precipitate thus formed is filtered off, washed neutral with water and dissolved in the calculated amount of cold soda solution. It is filtered and precipitated by acidification.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung der 3-1V1_ethyl- 2-oxybenzyl-phthalimid-5-arsinsäure der For mel EMI0002.0001 dadurch gekennzeichnet, dass man 3-Methyl- 4-oxyphenyl-l-arsinsäure in saurer Lösung mit Oxymethylphthalimid kondensiert. Die 3-Metäyl-2-oxyaenzyl-phthalimid-5- arsinsäure stellt ein weisses Pulver dar vom Schmelzpunkt ungefähr 273 . PATENT CLAIM: Process for the preparation of 3-1V1_ethyl- 2-oxybenzyl-phthalimid-5-arsinic acid of the formula EMI0002.0001 characterized in that 3-methyl-4-oxyphenyl-l-arsinic acid is condensed in acidic solution with oxymethylphthalimide. 3-Metäyl-2-oxyaenzyl-phthalimid-5-arsinic acid is a white powder with a melting point of about 273. Sie ist leicht löslich in verdünnten Alkalien, in verdünnter Soda- und Acetatlösung; schwerer in heissem Spiritus und unlöslich in Äther, Benzol, Ben zin und in verdünnten Säuren. Sie soll für pharmazeutische Zwecke und zur Herstellung weiterer pharmazeutischer Produkte verwen det werden. It is easily soluble in dilute alkalis, in dilute soda and acetate solutions; heavier in hot alcohol and insoluble in ether, benzene, benzine and in dilute acids. It is intended to be used for pharmaceutical purposes and for the manufacture of other pharmaceutical products.
CH139075D 1927-05-31 1928-05-29 Process for the preparation of an o-oxybenzyl-aroylamine-arsic acid. CH139075A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE139075X 1927-05-31
CH137210T 1928-05-29

Publications (1)

Publication Number Publication Date
CH139075A true CH139075A (en) 1930-03-31

Family

ID=25712884

Family Applications (1)

Application Number Title Priority Date Filing Date
CH139075D CH139075A (en) 1927-05-31 1928-05-29 Process for the preparation of an o-oxybenzyl-aroylamine-arsic acid.

Country Status (1)

Country Link
CH (1) CH139075A (en)

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