CH220928A - Process for the preparation of a reactive chlorine-containing isatin compound. - Google Patents

Process for the preparation of a reactive chlorine-containing isatin compound.

Info

Publication number
CH220928A
CH220928A CH220928DA CH220928A CH 220928 A CH220928 A CH 220928A CH 220928D A CH220928D A CH 220928DA CH 220928 A CH220928 A CH 220928A
Authority
CH
Switzerland
Prior art keywords
preparation
reactive chlorine
isatin compound
containing isatin
compound
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH220928A publication Critical patent/CH220928A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur     Herstellung    einer reaktionsfähiges Chlor enthaltenden       Isatinverbindung.       Gegenstand dieses Patentes ist ein Ver  fahren zur Herstellung einer reaktionsfähiges  Chlor enthaltenden, als Zwischenprodukt       verwendbaren        Isatinverbindung,    die wahr  scheinlich folgende     Konstitution    besitzt:  
EMI0001.0006     
    Das Verfahren ist dadurch     gekennzeichnet,     .     dass    man auf     5-Bromisatin        in    Gegenwart von       Chlorsulfonsäure        Chlorwasserstoffsäure    ein  wirken lässt.

   Man kann die Chlorwasserstoff  säure als Gas einleiten oder     ein    Salz zufügen,  das mit     Chlorsulfonsäure    Chlorwasserstoff  säure bildet. Man kann die     Chlorsulfonsäure     auch durch konzentrierte     ,Schwefelsäure    ver  dünnen.

      <I>Beispiel:</I>  80     Gewichtsteile        5-Bromisatin    werden bei  10-20' unter Rühren in 400     Gewichtsteile          Chlorsulfonsäure    eingetragen.     Hierauf    lässt  man die Temperatur langsam     ansteigen        und     erhitzt dann     einige        Stunden    auf 60  . Schliess  lich     wird        auf    Eis gegossen, der farblose  Niederschlag     abfiltriert    und mit kaltem  Wasser gewaschen.

   Die     Verbindung    kristalli  siert aus Benzol in farblosen     Prismen,    die bei  172       schmelzen.  



  Process for the preparation of a reactive chlorine-containing isatin compound. The subject of this patent is a process for the production of a reactive chlorine-containing isatin compound which can be used as an intermediate product and which probably has the following constitution:
EMI0001.0006
    The method is characterized by. that hydrochloric acid is allowed to act on 5-bromoisatin in the presence of chlorosulfonic acid.

   The hydrochloric acid can be introduced as a gas or a salt can be added, which forms hydrochloric acid with chlorosulfonic acid. The chlorosulfonic acid can also be diluted with concentrated sulfuric acid.

      <I> Example: </I> 80 parts by weight of 5-bromoisatin are introduced into 400 parts by weight of chlorosulphonic acid at 10-20 'with stirring. The temperature is then allowed to rise slowly and then heated to 60 for a few hours. Finally, it is poured onto ice, the colorless precipitate is filtered off and washed with cold water.

   The compound crystallizes from benzene in colorless prisms that melt at 172.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer reak tionsfähiges Chlor enthaltenden Isatinverbin.- dung, dadurch gekennzeichnet, dass man auf 5-Bromisatin Chlorwasserstoffsäure in Gegen wart von Chlorsulfonsäure einwirken lässt. Die neue Verbindung kristallisiert aus Benzol in farblosen Prismen vom Smp. 172 . PATENT CLAIM: Process for producing a reactive chlorine-containing isatin compound, characterized in that 5-bromoisatin is allowed to act on hydrochloric acid in the presence of chlorosulfonic acid. The new compound crystallizes from benzene in colorless prisms with a melting point of 172.
CH220928D 1938-09-17 1939-09-09 Process for the preparation of a reactive chlorine-containing isatin compound. CH220928A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE220928X 1938-09-17
CH213906T 1939-09-09

Publications (1)

Publication Number Publication Date
CH220928A true CH220928A (en) 1942-04-30

Family

ID=25725515

Family Applications (1)

Application Number Title Priority Date Filing Date
CH220928D CH220928A (en) 1938-09-17 1939-09-09 Process for the preparation of a reactive chlorine-containing isatin compound.

Country Status (1)

Country Link
CH (1) CH220928A (en)

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