CH104252A - Process for the preparation of di-carbethoxy-di-phenolisatin. - Google Patents

Process for the preparation of di-carbethoxy-di-phenolisatin.

Info

Publication number
CH104252A
CH104252A CH104252DA CH104252A CH 104252 A CH104252 A CH 104252A CH 104252D A CH104252D A CH 104252DA CH 104252 A CH104252 A CH 104252A
Authority
CH
Switzerland
Prior art keywords
phenolisatin
carbethoxy
preparation
alcohol
diphenolisatin
Prior art date
Application number
Other languages
German (de)
Inventor
F Hoffmann- Aktiengesellschaft
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CH104252A publication Critical patent/CH104252A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

  

  Verfahren zur Darstellung von     Di-earbäthogy-di-phenolisatin.            Es    wurde gefunden, dass das bisher unbe  kannte     Di-carbäthoxy-di-phenolisatin        dadurch     erhalten werden kann, dass man     Diphenol-          isatin    mit     Chlorameisenester    bei Tempera  turen unter<B>100'</B> behandelt.  



  Das     Di-carbäthoxy-:di-phenolisatin        kri-          stallisiert    aus     verdünntem        Alkohol        in    weissen  Nadeln vom Schmelzpunkt 156 bis<B>157'.</B> Es  ist leicht löslich in Benzol, Alkohol und<B>DA</B>     is-          essig,    unlöslich in Wasser.     Mit        kalter    wäs  seriger Lauge tritt langsam     Verseifung    ein,  rascher in der Wärme.  



  Das     Di-carbäthoxy-di-phenolisatin    soll in  der     Therapie    Verwendung     finden.     



       Beispiel:     16 Gewichtsteile     Diplienolisatin    . werden  in 220 Gewichtsteilen     -Wasser    unter Zusatz  von 40     -Gewichtsteilen    11,45     %iger    Natron  lauge gelöst. Man kühlt die Lösung unter  Rühren stark ab und setzt unter 0   allmäh  lich 11     gr        Chlorameisenester    zu.     INTach    drei  stündigem Verrühren     wird    der gebildete Nie-         derschlag        abfiltriert,        gewaschen    und getrock  net.

   Durch     Umkristallisieren    aus     zirka     45     %igem    Alkohol erhält man das Produkt  in weissen Nadeln vom Schmelzpunkt 156  bis 157  .



  Process for the preparation of di-earbäthogy-di-phenolisatin. It has been found that the previously unknown di-carbethoxy-di-phenolisatin can be obtained by treating diphenol isatin with chloroformic ester at temperatures below <B> 100 '</B>.



  The di-carbethoxy-: di-phenolisatin crystallizes from dilute alcohol in white needles with a melting point of 156 to <B> 157 '. </B> It is easily soluble in benzene, alcohol and <B> DA </B> is - vinegar, insoluble in water. With cold aqueous lye, saponification occurs slowly, more quickly when it is warm.



  The di-carbethoxy-di-phenolisatin is said to be used in therapy.



       Example: 16 parts by weight of Diplienolisatin. are dissolved in 220 parts by weight of water with the addition of 40 parts by weight of 11.45% sodium hydroxide solution. The solution is cooled vigorously with stirring and 11 grams of chloroformic ester are gradually added under 0. After three hours of stirring, the precipitate formed is filtered off, washed and dried.

   Recrystallization from about 45% alcohol gives the product in white needles with a melting point of 156 to 157.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von Di-carb- äthoxy-di-phenolisatin, dadurch gekennzeich- net, dass man Diphenolisatin mit Chloramei- senester bei Temperaturen unter<B>100'</B> be handelt. PATENT CLAIM: Process for the preparation of di-carb-ethoxy-di-phenolisatin, characterized in that diphenolisatin is treated with chlorame iron ester at temperatures below <B> 100 '</B>. Das Di-carbäthoxy-di-phenolisatin kri stallisiert aus verdünntem Alkohol in weissen Nadeln vom Schmelzpunkt 156 bis<B>157'.</B> Es ist leicht löslich in Benzol, Alkohol und Eis essig, unlöslich in Wasser. Mit kalter wäs seriger Lauge tritt langsam Verseifung ein, rascher in der Wärme. Das Di-carbäthoxy-di-phenolisatin soll in der Therapie Verwendung finden. The di-carbethoxy-diphenolisatin crystallizes from dilute alcohol in white needles with a melting point of 156 to <B> 157 '. </B> It is easily soluble in benzene, alcohol and glacial acetic acid, insoluble in water. With cold aqueous lye, saponification occurs slowly, more quickly when it is warm. The di-carbethoxy-di-phenolisatin is said to be used in therapy.
CH104252D 1922-11-27 1923-06-15 Process for the preparation of di-carbethoxy-di-phenolisatin. CH104252A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH100806T 1922-11-27
CH104252T 1923-06-15

Publications (1)

Publication Number Publication Date
CH104252A true CH104252A (en) 1924-07-16

Family

ID=25705905

Family Applications (1)

Application Number Title Priority Date Filing Date
CH104252D CH104252A (en) 1922-11-27 1923-06-15 Process for the preparation of di-carbethoxy-di-phenolisatin.

Country Status (1)

Country Link
CH (1) CH104252A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4545618A (en) * 1984-02-22 1985-10-08 Tachikawa Spring Co., Ltd. Head-rest device

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4545618A (en) * 1984-02-22 1985-10-08 Tachikawa Spring Co., Ltd. Head-rest device

Similar Documents

Publication Publication Date Title
CH104252A (en) Process for the preparation of di-carbethoxy-di-phenolisatin.
AT99211B (en) Process for the preparation of o-o-diazyl derivatives of diphenolisatin and its derivatives substituted in the phenol or isatin radical.
CH312530A (en) Process for making a pyridazone.
DE439290C (en) Process for the preparation of naphthooxythiophenes
AT107857B (en) Process for the preparation of quinine salts of oxyphenylarsinic acids.
CH104253A (en) Process for the preparation of di-carbethoxy-di-guaiacolisatin.
AT93325B (en) Process for the preparation of the arsinic acids of aliphatic carboxylic acids.
AT111573B (en) Process for the preparation of alkyl and aralkyl derivatives of 1-aryl-3,4-trimethylene-5-pyrazolones.
CH182585A (en) Process for the preparation of a heterocyclic amino compound.
CH147685A (en) Process for the preparation of an aminodiphenylamine derivative.
CH104251A (en) Process for the preparation of O-O-di-benzoyl-di-phenolisatin.
CH123269A (en) Process for the production of a new indigoid dye.
CH106124A (en) Process for the preparation of 4-chloro-1,2-thionaphthisatin.
CH106125A (en) Process for the preparation of a thioindoxyl derivative.
CH139075A (en) Process for the preparation of an o-oxybenzyl-aroylamine-arsic acid.
CH105234A (en) Process for the production of 2.1-thionaphthisatin.
CH215336A (en) Process for the preparation of an aminoarylsulfoxide.
CH175892A (en) Process for the preparation of 4-methyl-2-amino-2&#39;.4&#39;-dichloroazobenzene.
CH175234A (en) Process for the preparation of 4-amino-3-ethoxy-4&#39;-methoxy-diphenylamine.
CH123272A (en) Process for the production of a new indigoid dye.
CH106133A (en) Process for the preparation of 2,3-thionaphthisatin.
CH170447A (en) Process for the production of a monooxychrysenic.
CH91107A (en) Process for the preparation of a dioxynaphtoylbenzoic acid ester.
CH206603A (en) Process for the preparation of an o-haloanthraquinone-B-carboxylic acid.
CH91106A (en) Process for the preparation of a dioxynaphtoylbenzoic acid ester.