AT107857B - Process for the preparation of quinine salts of oxyphenylarsinic acids. - Google Patents

Process for the preparation of quinine salts of oxyphenylarsinic acids.

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Publication number
AT107857B
AT107857B AT107857DA AT107857B AT 107857 B AT107857 B AT 107857B AT 107857D A AT107857D A AT 107857DA AT 107857 B AT107857 B AT 107857B
Authority
AT
Austria
Prior art keywords
oxyphenylarsinic
acids
quinine
preparation
quinine salts
Prior art date
Application number
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German (de)
Original Assignee
Hoffmann La Roche
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Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
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Publication of AT107857B publication Critical patent/AT107857B/en

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Description

  

   <Desc/Clms Page number 1> 
 



  Verfahren zur Darstellung von Chininsalzen der   Oxyphenylarsmsäuren.   



   Es wurde gefunden, dass den bisher nicht bekannten Chininsalzen der   Oxyphenylarsin-   säuren wertvolle therapeutische Eigenschaften zukommen. Zur Gewinnung der Chininsalze der   Oxyphenylarsinsäuren kann   man die freien Oxyphenylarsinsäuren mit Chinin oder oxyphenylarsinsaure Salze mit   löslichen   Chininsalzen umsetzen. 



   Die Chininsalze der Oxyphenylarsinsäuren zeichnen sich durch gute Kristallisationsfühigkeit aus. Sie sind   ziemlich schwer löslich in kaltem,   leicht löslich in heissem Wasser ; ferner lösen sie sich in Alkohol und in verdünnten Mineralsäuren. Die wässerigen Lösungen reagieren   lackmus-neutral   ; bei Zugabe von Alkalien fällt Chinin aus. Sie sollen als Heilmittel Verwendung finden. 



   Beispiel   l : l   Mol Mononatriumsalz der p-Oxyphenylarsinsäure wird in der 10fachen 
 EMI1.1 
 Wasser   hinzugefügt.   Es entsteht ein dicker Niederschlag ;   man   trennt denselben von der Mutterlauge und kristallisiert das erhaltene Salz aus heissem   Wasser um.   Das Chininsalz der   p-Oxy-   phenylarsinsäure kristallisiert in feinen, farblosen Nädelchen, welche nach dem Trocknen bei 105 einenSchmelzpunktvon177-178 aufweisen. 



   Beispiel 2 : 1 Mol p-Oxyphenylarsinsäure und 1 Mol Chinin werden in der 30fachen Menge Wasser 8 Stunden auf dem Wasserhad erhitzt.* Beim Erkalten schedet sich das Chininsalz der   p-Oxyphenylarsinsänre   in feinen Nadeln ab. Nach einmaligem Umkristallisieren aus   heissem   Wasser erhält man ein Salz, welches dem nach Beispiel 1 gewonnenen entspricht. 



   Beispiel 3 : 1 Mol 3-Acetamino-4-oxyphenylarsinsäure wird mit 1 Mol Chinin in der 20fachen Menge Wasser 8 Stunden auf dem Dampfbad erhitzt. Beim Abkühlen der Lösung scheidet 
 EMI1.2 
   Salzes liegt bei 176--177 .   

**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.



   <Desc / Clms Page number 1>
 



  Process for the preparation of quinine salts of oxyphenyl arsenic.



   It has been found that the previously unknown quinine salts of oxyphenylarsinic acids have valuable therapeutic properties. To obtain the quinine salts of the oxyphenylarsinic acids, the free oxyphenylarsinic acids can be reacted with quinine or oxyphenylarsinic acid salts with soluble quinine salts.



   The quinine salts of oxyphenylarsinic acids are distinguished by their good crystallization ability. They are rather sparingly soluble in cold, easily soluble in hot water; they also dissolve in alcohol and in dilute mineral acids. The aqueous solutions are litmus-neutral; quinine precipitates when alkalis are added. They are said to be used as remedies.



   Example 1: 1 mol of the monosodium salt of p-oxyphenylarsinic acid is 10 times as high
 EMI1.1
 Water added. A thick precipitate forms; it is separated from the mother liquor and the salt obtained is recrystallized from hot water. The quinine salt of p-oxyphenylarsinic acid crystallizes in fine, colorless needles which, after drying, have a melting point of 177-178 at 105.



   Example 2: 1 mole of p-oxyphenylarsinic acid and 1 mole of quinine are heated in 30 times the amount of water for 8 hours on the water heater. After recrystallizing once from hot water, a salt is obtained which corresponds to that obtained in Example 1.



   Example 3: 1 mol of 3-acetamino-4-oxyphenylarsinic acid is heated with 1 mol of quinine in 20 times the amount of water for 8 hours on the steam bath. When the solution cools, it separates
 EMI1.2
   Salt is 176-177.

** WARNING ** End of DESC field may overlap beginning of CLMS **.

Claims (1)

PATENT-ANSPRUCH : Verfahren zur Darstellung von Chinsalzen der Oxyphenylarsinsäuren, dadurch gekenn- EMI1.3 **WARNUNG** Ende CLMS Feld Kannt Anfang DESC uberlappen**. PATENT CLAIM: Process for the preparation of quin salts of oxyphenylarsinic acids, characterized by EMI1.3 ** WARNING ** End of CLMS field may overlap beginning of DESC **.
AT107857D 1925-11-06 1926-06-16 Process for the preparation of quinine salts of oxyphenylarsinic acids. AT107857B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH107857X 1925-11-06

Publications (1)

Publication Number Publication Date
AT107857B true AT107857B (en) 1927-11-10

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ID=4366839

Family Applications (1)

Application Number Title Priority Date Filing Date
AT107857D AT107857B (en) 1925-11-06 1926-06-16 Process for the preparation of quinine salts of oxyphenylarsinic acids.

Country Status (1)

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AT (1) AT107857B (en)

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