CH100807A - A method of preparing a bismuth salt of a mercurized organic compound containing an acid residue. - Google Patents

A method of preparing a bismuth salt of a mercurized organic compound containing an acid residue.

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Publication number
CH100807A
CH100807A CH100807DA CH100807A CH 100807 A CH100807 A CH 100807A CH 100807D A CH100807D A CH 100807DA CH 100807 A CH100807 A CH 100807A
Authority
CH
Switzerland
Prior art keywords
bismuth
mercurized
compound containing
preparing
mercury
Prior art date
Application number
Other languages
German (de)
Inventor
Farbwerke Vorm Meiste Bruening
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of CH100807A publication Critical patent/CH100807A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  verfahren zur Darstellung eines     Wismutsalzes    einer     merkurierten,    organischen,  einen Säurerest enthaltenden Verbindung.    Es wurde gefunden, dass man zu einer  therapeutisch wichtigen, gleichzeitig Queck  silber und Wismut enthaltenden Verbindung  gelangen kann, wenn man     Merkurisalicylsäure     in Form ihrer     Alkalisalze    mit     Wismutsalzen     zusammen bringt.

   Der Gehalt an Quecksilber  und Wismut schwankt je nach der Menge  der angewandten     Komponenten.    Die neue  Verbindung zeichnet sich durch eine kräftige       Wirkung    bei Syphilis aus und ist weniger       giftig-,    als nach ihrem Gehalt an     merkurierter     Verbindung erwartet werden sollte.  



  <I>Beispiel:</I>  10 g     Merkurisalicylsäure    werden in 100 ccm  Wasser unter Zugabe von Natronlauge gelöst  und mit einer Lösung von     9,"5    g Wismut  chlorid in 10 ccm konzentrierter Salzsäure  und g-0 ccm Wasser vereinigt. Es entsteht  ein weisser, voluminöser Niederschlag, der       nach        dem        Trocknen        33,9        %        Quecksilber        und          36        %        Wismut        enthält.  



  Process for the preparation of a bismuth salt of a mercurized, organic compound containing an acid residue. It has been found that a therapeutically important compound containing both mercury and bismuth can be obtained by combining mercury salicylic acid in the form of its alkali metal salts with bismuth salts.

   The content of mercury and bismuth varies depending on the amount of the components used. The new compound is characterized by a powerful effect on syphilis and is less toxic than should be expected from its mercurated compound content.



  <I> Example: </I> 10 g of mercury salicylic acid are dissolved in 100 cc of water with the addition of sodium hydroxide solution and combined with a solution of 9.5 g of bismuth chloride in 10 cc of concentrated hydrochloric acid and 0 cc of water white, voluminous precipitate which, after drying, contains 33.9% mercury and 36% bismuth.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung des WiSmut- salzes der Merkur-isalicylsäure, darin be stehend, dass man 1Vlerkurisalicylsäure in Form ihrer Alkalisalze mit Wismutsalzen zu sammen bringt. Der Gehalt des Präparates an Quecksilber und Wismut schwankt je nach der Menge der angewandten Kompo nenten. PATENT CLAIM: Process for the preparation of the WiSmut salt of mercury isalicylic acid, which consists of bringing 1Vlerkurisalicylic acid in the form of its alkali salts together with bismuth salts. The mercury and bismuth content of the preparation varies depending on the amount of components used. Das im Beispiel beschriebene Produkt wird als weisser voluminöser Niederschlag gefällt, enthält nach dem Trocknen 33,9 % Quecksilber und 36 % Wismut und zeichnet sich durch eine kräftige Wirkung bei Syphilis aus und ist weniger giftig, als nach seinem Gehalt an merkurierter Verbindung erwartet werden sollte. The product described in the example is precipitated as a white voluminous precipitate, contains 33.9% mercury and 36% bismuth after drying and is characterized by a powerful effect on syphilis and is less toxic than should be expected based on its mercurated compound content .
CH100807D 1922-01-25 1923-01-22 A method of preparing a bismuth salt of a mercurized organic compound containing an acid residue. CH100807A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE100807X 1922-01-25

Publications (1)

Publication Number Publication Date
CH100807A true CH100807A (en) 1923-08-16

Family

ID=5648665

Family Applications (1)

Application Number Title Priority Date Filing Date
CH100807D CH100807A (en) 1922-01-25 1923-01-22 A method of preparing a bismuth salt of a mercurized organic compound containing an acid residue.

Country Status (1)

Country Link
CH (1) CH100807A (en)

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