DE666789C - Process for the production of sulfur-containing heavy metal complex compounds - Google Patents

Process for the production of sulfur-containing heavy metal complex compounds

Info

Publication number
DE666789C
DE666789C DESCH99412D DESC099412D DE666789C DE 666789 C DE666789 C DE 666789C DE SCH99412 D DESCH99412 D DE SCH99412D DE SC099412 D DESC099412 D DE SC099412D DE 666789 C DE666789 C DE 666789C
Authority
DE
Germany
Prior art keywords
sulfur
production
heavy metal
containing heavy
metal complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DESCH99412D
Other languages
German (de)
Inventor
Dr Adolf Feldt
Dr Victor Fischl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DESCH99412D priority Critical patent/DE666789C/en
Application granted granted Critical
Publication of DE666789C publication Critical patent/DE666789C/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Description

Verfahren zur Herstellung von schwefelhaltigen Schwermetallkomplexverbindungen Nach Patent 645 726 werden aus den nach den Patentschriften 527 036 und 625 995 erhältlichen Mercaptoverbindungen therapeutisch wirksamer Schwermetalle sowie aus den Komplexverbindungen nach den Verfahren der Patentschriften 5,73 629 und 575 59$ neue Verbindungen, die gegenüber den Ausgangsstoffen ungiftiger und ebenso oder stärker wirksam sind; in der .Weise gewonnen, daß man die Ausgangsstoffe in Lösung mit mehr als i Mol. geeigneter schwefelhaltiger Verbindungen erhitzt. Solche Verbindungen sind anorganische oderorganische Tl@iosäuren bzw. deren Alkali- oder Erdalkalisalze, z. B. Natriumthiosulfat, Cystein; _ Natriumthioglycol.at usw., organische Sulfhydrylverbindungen der allgemeinen Formel R # S # Ri, worin R einen aliph,atischen, aromatischen oder hetero-.cyclischen Rest, R, Wiasserstoff oder ein Alkali-oder Erdalkalimetall bedeuten, wie z. B. thiosubstituierte. KohIehydrate und andere mehr.Process for the production of sulfur-containing heavy metal complex compounds According to patent 645 726, the mercapto compounds of therapeutically active heavy metals obtainable according to patents 527 036 and 625 995 and the complex compounds according to the processes of patents 5, 73 629 and 575 59 $ are transformed into new compounds that are different from the starting materials are less toxic and equally or more effective; Obtained in the way that the starting materials are heated in solution with more than one mole of suitable sulfur-containing compounds. Such compounds are inorganic or organic Tl @ iosäuren or their alkali or alkaline earth salts, z. B. sodium thiosulfate, cysteine; _ Sodium thioglycol.at etc., organic sulfhydryl compounds of the general formula R # S # Ri, where R is an aliphatic, aromatic, aromatic or hetero-.cyclic radical, R, hydrogen or an alkali or alkaline earth metal, such as. B. thio-substituted. Carbohydrates and others.

Überraschenderweise hat sich ergeben"daß nun bei Übertragung dieses Verfahrens auf Verbindungen des Iridiums, Palladiums oder Tantals, die bisher keine therapeutische Bedeutung besitzen, zu therapeutisch wirksamen Stoffen ,gelangen, kann, wenn man sie in wäß-Tiger Lösung in der Siedehitze mit mehr als i Mol. der im Hauptpatent genannten schwefelhaltigen Verbindungen umsetzt.Surprisingly, it turned out that when this Procedure on compounds of iridium, palladium or tantalum, which so far have not been used have therapeutic significance, reach therapeutically effective substances, can, if you boil them in water-tiger solution with more than i mol. of converts sulfur-containing compounds mentioned in the main patent.

Beispiel i Gleiche Gewichtsmengen von Kaliumhexatantalat und Natriumthiosulfat werden in der iofachen Menge Wasser einmal kurz aufgekocht. Während das Ausg-angsprodukt (Kaliumhexatantalat) von Mäusen nur in einer Menge von ö,ooo5 g pro 2o g Gewicht vertragen wird und sich sowohl bei Rekurrensspirochätose als auch bei Naganatrypanese als wirkungsvoll erweist, wird die Komplexverbindung noch in. einer Dosis von 0,o25 g vertragen und heilt beide genannten Infektionen vorübergehend aus.Example i Equal amounts by weight of potassium hexatantalate and sodium thiosulfate are briefly boiled once in ten times the amount of water. While the base product (Potassium hexatantalate) from mice only in an amount of Ö, ooo5 g per 20 g weight is tolerated and is suitable for both recurrent spirochatosis and naganatrypanese proves to be effective, the complex compound is still in a dose of 0.025 g tolerates and temporarily heals both of these infections.

Beispiel 2 Gleiche Gewichtsmengen von Iridiumnatriumchlorid und Natriumthiogliuoose werden in der 5fachen Menge von o,9 %iger Kochsalzlösung kurz aufgekocht. Die Dos. tol. des unwirksamen Ausgangsproduktes beträgt für Mäuse 0,025 g; das Endprodukt besitzt Heilwirkung und wird in einer Dosis von o, i g vertragen.Example 2 Equal amounts by weight of iridium sodium chloride and sodium thiogliuose are briefly boiled in 5 times the amount of 0.9% sodium chloride solution. The Dos. tol. the ineffective starting product is 0.025 g for mice; the end product has medicinal properties and is tolerated in a dose of o, ig.

Claims (1)

PATENTANSPRUCH: Abänderung des Verfahrens des Ha patents 645 726 zur Herstellung .@ schwefelhaltigen Schwermetallkomplexver,='@
bindungen, dadurch gekennzeichnet, daß man hier Verbindungen des Iridiums, Palladiums oder Tantals in wäßriger Lösung in der Siedehitze mit mehr als r Mol. der .,im Hauptpatent genannten schwefelhaltigen Verbindungen umsetzt. PATENT CLAIM: Modification of the Ha patents 645 726 for the production. @ sulfur-containing heavy metal complexver, = '@
bonds, characterized in that compounds of iridium, palladium or tantalum are reacted here in an aqueous solution at boiling point with more than r moles of the sulfur-containing compounds mentioned in the main patent.
DESCH99412D 1932-11-06 1932-11-06 Process for the production of sulfur-containing heavy metal complex compounds Expired DE666789C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DESCH99412D DE666789C (en) 1932-11-06 1932-11-06 Process for the production of sulfur-containing heavy metal complex compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DESCH99412D DE666789C (en) 1932-11-06 1932-11-06 Process for the production of sulfur-containing heavy metal complex compounds

Publications (1)

Publication Number Publication Date
DE666789C true DE666789C (en) 1938-10-28

Family

ID=7446598

Family Applications (1)

Application Number Title Priority Date Filing Date
DESCH99412D Expired DE666789C (en) 1932-11-06 1932-11-06 Process for the production of sulfur-containing heavy metal complex compounds

Country Status (1)

Country Link
DE (1) DE666789C (en)

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